Optimising the removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water
1 The efficacy of ZnDTPA administered in drinking water has been investigated for removing 238 Pu and 241Am from the rat after their simultaneous inhalation as nitrates. 2 The continual administration of ZnDTPA 95 μmol kg-1 d-1 over a 21 d interval commencing 1 h after exposure reduced the 238Pu con...
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| Veröffentlicht in: | Human & experimental toxicology 1995-11, Vol.14 (11), p.902-908 |
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| creator | Gray, SA Pearce, MJ Stradling, GN Wilson, I. Hodgson, A. Isaacs, KR |
| description | 1 The efficacy of ZnDTPA administered in drinking water has been investigated for removing 238 Pu and 241Am from the rat after their simultaneous inhalation as nitrates.
2 The continual administration of ZnDTPA 95 μmol kg-1 d-1 over a 21 d interval commencing 1 h after exposure reduced the 238Pu content of the lungs and total body to 2% and 8% of those in untreated animals; the corresponding values for 241Am were 3% and 5%.
3 The continual intakes of 950 μmol kg-1 d-1, intermittent intakes of 3600 μmol kg-1 d-1 and the repeated injection of 30 μmol kg-1 body weight were considered no more effective. 4 All orally administered concentrations of ZnDTPA, commencing 7 d after exposure, reduced the total body contents of 238Pu and 241Am to 17% and 20% of controls by 28 d.
5 Histopathological examination of the kidneys, liver and gastrointestinal tract showed no apparent effects of these treatment protocols.
6 It is concluded that the oral administration of ZnDTPA could be an effective treatment for the removal of inhaled transportable forms of Pu and Am after human exposure. |
| doi_str_mv | 10.1177/096032719501401108 |
| format | Article |
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2 The continual administration of ZnDTPA 95 μmol kg-1 d-1 over a 21 d interval commencing 1 h after exposure reduced the 238Pu content of the lungs and total body to 2% and 8% of those in untreated animals; the corresponding values for 241Am were 3% and 5%.
3 The continual intakes of 950 μmol kg-1 d-1, intermittent intakes of 3600 μmol kg-1 d-1 and the repeated injection of 30 μmol kg-1 body weight were considered no more effective. 4 All orally administered concentrations of ZnDTPA, commencing 7 d after exposure, reduced the total body contents of 238Pu and 241Am to 17% and 20% of controls by 28 d.
5 Histopathological examination of the kidneys, liver and gastrointestinal tract showed no apparent effects of these treatment protocols.
6 It is concluded that the oral administration of ZnDTPA could be an effective treatment for the removal of inhaled transportable forms of Pu and Am after human exposure.</description><identifier>ISSN: 0960-3271</identifier><identifier>ISSN: 0144-5952</identifier><identifier>EISSN: 1477-0903</identifier><identifier>DOI: 10.1177/096032719501401108</identifier><identifier>PMID: 8588952</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Administration, Inhalation ; Administration, Oral ; Americium - administration & dosage ; Americium - metabolism ; Americium - toxicity ; Animals ; Biological and medical sciences ; Biological effects of radiation ; Chelating Agents - administration & dosage ; Chelating Agents - pharmacology ; Colon - drug effects ; Colon - pathology ; Drinking ; Duodenum - drug effects ; Duodenum - pathology ; Female ; Fundamental and applied biological sciences. Psychology ; Ileum - drug effects ; Ileum - pathology ; Injections, Intraperitoneal ; Ionizing radiations ; Kidney - drug effects ; Kidney - pathology ; Liver - drug effects ; Liver - pathology ; Lung - metabolism ; Pentetic Acid - administration & dosage ; Pentetic Acid - pharmacology ; Plutonium - administration & dosage ; Plutonium - metabolism ; Plutonium - toxicity ; Rats ; Tissues, organs and organisms biophysics ; Zinc - pharmacology</subject><ispartof>Human & experimental toxicology, 1995-11, Vol.14 (11), p.902-908</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-8f6aef4420112cfee0aab427643999ed5f7c398ffe209915e5648712e345117e3</citedby><cites>FETCH-LOGICAL-c429t-8f6aef4420112cfee0aab427643999ed5f7c398ffe209915e5648712e345117e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/096032719501401108$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/096032719501401108$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2896746$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8588952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gray, SA</creatorcontrib><creatorcontrib>Pearce, MJ</creatorcontrib><creatorcontrib>Stradling, GN</creatorcontrib><creatorcontrib>Wilson, I.</creatorcontrib><creatorcontrib>Hodgson, A.</creatorcontrib><creatorcontrib>Isaacs, KR</creatorcontrib><title>Optimising the removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water</title><title>Human & experimental toxicology</title><addtitle>Hum Exp Toxicol</addtitle><description>1 The efficacy of ZnDTPA administered in drinking water has been investigated for removing 238 Pu and 241Am from the rat after their simultaneous inhalation as nitrates.
2 The continual administration of ZnDTPA 95 μmol kg-1 d-1 over a 21 d interval commencing 1 h after exposure reduced the 238Pu content of the lungs and total body to 2% and 8% of those in untreated animals; the corresponding values for 241Am were 3% and 5%.
3 The continual intakes of 950 μmol kg-1 d-1, intermittent intakes of 3600 μmol kg-1 d-1 and the repeated injection of 30 μmol kg-1 body weight were considered no more effective. 4 All orally administered concentrations of ZnDTPA, commencing 7 d after exposure, reduced the total body contents of 238Pu and 241Am to 17% and 20% of controls by 28 d.
5 Histopathological examination of the kidneys, liver and gastrointestinal tract showed no apparent effects of these treatment protocols.
6 It is concluded that the oral administration of ZnDTPA could be an effective treatment for the removal of inhaled transportable forms of Pu and Am after human exposure.</description><subject>Administration, Inhalation</subject><subject>Administration, Oral</subject><subject>Americium - administration & dosage</subject><subject>Americium - metabolism</subject><subject>Americium - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Chelating Agents - administration & dosage</subject><subject>Chelating Agents - pharmacology</subject><subject>Colon - drug effects</subject><subject>Colon - pathology</subject><subject>Drinking</subject><subject>Duodenum - drug effects</subject><subject>Duodenum - pathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ileum - drug effects</subject><subject>Ileum - pathology</subject><subject>Injections, Intraperitoneal</subject><subject>Ionizing radiations</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Lung - metabolism</subject><subject>Pentetic Acid - administration & dosage</subject><subject>Pentetic Acid - pharmacology</subject><subject>Plutonium - administration & dosage</subject><subject>Plutonium - metabolism</subject><subject>Plutonium - toxicity</subject><subject>Rats</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Zinc - pharmacology</subject><issn>0960-3271</issn><issn>0144-5952</issn><issn>1477-0903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9LHTEUxUOp6Kv2CxQKWRR3o0kmf5eitRUEXejGzZA3c6OxM8kzybT47ZvhPdwU6upyub9zLvcehL5QckKpUqfESNIyRY0glBNKif6AVpQr1RBD2o9otQDNQhygTzk_E0KkEXQf7WuhtRFshcrNpvjJZx8ecXkCnGCKv-2Io8M-PNkRBrwZ5xKDnydsw4DtBMn3S-dSnLYaW_D6Fdth8sHnUlsfw-LwEC7ubs-qER6SD7-WHX9sgXSE9pwdM3ze1UN0f_n97vxnc33z4-r87LrpOTOl0U5acJyzehrrHQCxds2Zkrw1xsAgnOpbo50DRoyhAoTkWlEGLRf1P9AeouOt7ybFlxly6eqlPYyjDRDn3DFKpFSUvAtSaVQruK4g24J9ijkncN0m-cmm146Sbsmk-zeTKvq6c5_XEwxvkl0Idf5tN7e5t6NLNvQ-v2FMG6m4rNjpFsv2EbrnOKdQn_e_xX8B3vKg-g</recordid><startdate>19951101</startdate><enddate>19951101</enddate><creator>Gray, SA</creator><creator>Pearce, MJ</creator><creator>Stradling, GN</creator><creator>Wilson, I.</creator><creator>Hodgson, A.</creator><creator>Isaacs, KR</creator><general>SAGE Publications</general><general>Arnold</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19951101</creationdate><title>Optimising the removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water</title><author>Gray, SA ; Pearce, MJ ; Stradling, GN ; Wilson, I. ; Hodgson, A. ; Isaacs, KR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-8f6aef4420112cfee0aab427643999ed5f7c398ffe209915e5648712e345117e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Administration, Inhalation</topic><topic>Administration, Oral</topic><topic>Americium - administration & dosage</topic><topic>Americium - metabolism</topic><topic>Americium - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Chelating Agents - administration & dosage</topic><topic>Chelating Agents - pharmacology</topic><topic>Colon - drug effects</topic><topic>Colon - pathology</topic><topic>Drinking</topic><topic>Duodenum - drug effects</topic><topic>Duodenum - pathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ileum - drug effects</topic><topic>Ileum - pathology</topic><topic>Injections, Intraperitoneal</topic><topic>Ionizing radiations</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Lung - metabolism</topic><topic>Pentetic Acid - administration & dosage</topic><topic>Pentetic Acid - pharmacology</topic><topic>Plutonium - administration & dosage</topic><topic>Plutonium - metabolism</topic><topic>Plutonium - toxicity</topic><topic>Rats</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Zinc - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gray, SA</creatorcontrib><creatorcontrib>Pearce, MJ</creatorcontrib><creatorcontrib>Stradling, GN</creatorcontrib><creatorcontrib>Wilson, I.</creatorcontrib><creatorcontrib>Hodgson, A.</creatorcontrib><creatorcontrib>Isaacs, KR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Human & experimental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gray, SA</au><au>Pearce, MJ</au><au>Stradling, GN</au><au>Wilson, I.</au><au>Hodgson, A.</au><au>Isaacs, KR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optimising the removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water</atitle><jtitle>Human & experimental toxicology</jtitle><addtitle>Hum Exp Toxicol</addtitle><date>1995-11-01</date><risdate>1995</risdate><volume>14</volume><issue>11</issue><spage>902</spage><epage>908</epage><pages>902-908</pages><issn>0960-3271</issn><issn>0144-5952</issn><eissn>1477-0903</eissn><abstract>1 The efficacy of ZnDTPA administered in drinking water has been investigated for removing 238 Pu and 241Am from the rat after their simultaneous inhalation as nitrates.
2 The continual administration of ZnDTPA 95 μmol kg-1 d-1 over a 21 d interval commencing 1 h after exposure reduced the 238Pu content of the lungs and total body to 2% and 8% of those in untreated animals; the corresponding values for 241Am were 3% and 5%.
3 The continual intakes of 950 μmol kg-1 d-1, intermittent intakes of 3600 μmol kg-1 d-1 and the repeated injection of 30 μmol kg-1 body weight were considered no more effective. 4 All orally administered concentrations of ZnDTPA, commencing 7 d after exposure, reduced the total body contents of 238Pu and 241Am to 17% and 20% of controls by 28 d.
5 Histopathological examination of the kidneys, liver and gastrointestinal tract showed no apparent effects of these treatment protocols.
6 It is concluded that the oral administration of ZnDTPA could be an effective treatment for the removal of inhaled transportable forms of Pu and Am after human exposure.</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>8588952</pmid><doi>10.1177/096032719501401108</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human & experimental toxicology, 1995-11, Vol.14 (11), p.902-908 |
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| subjects | Administration, Inhalation Administration, Oral Americium - administration & dosage Americium - metabolism Americium - toxicity Animals Biological and medical sciences Biological effects of radiation Chelating Agents - administration & dosage Chelating Agents - pharmacology Colon - drug effects Colon - pathology Drinking Duodenum - drug effects Duodenum - pathology Female Fundamental and applied biological sciences. Psychology Ileum - drug effects Ileum - pathology Injections, Intraperitoneal Ionizing radiations Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Lung - metabolism Pentetic Acid - administration & dosage Pentetic Acid - pharmacology Plutonium - administration & dosage Plutonium - metabolism Plutonium - toxicity Rats Tissues, organs and organisms biophysics Zinc - pharmacology |
| title | Optimising the removal of inhaled plutonium and americium from the rat by administration of ZnDTPA in drinking water |
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