Synthesis of substituted tetralones as intermediates of CNS agents via palladium-catalyzed cross-coupling reactions

Synthesis of substituted tetralones as intermediates of CNS agents via palladium-catalyzed cross-coupling reactions

A series of substituted tetralones as intermediates of CNS agents has been synthesized via Pd-catalyzed coupling reactions of 3-(methoxycarbonyl)-1,2,3,4-tetrahydro-1-oxonaphthalen-6-yl trifluoromethanesulfonate ( 5) with a variety of organometallic reagents.

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Veröffentlicht in:Tetrahedron letters 2007-01, Vol.48 (2), p.323-326
Hauptverfasser: Torrado, María, Masaguer, Christian F., Raviña, Enrique
Format: Artikel
Sprache:eng
Schlagworte:
Cyanation
Palladium-catalyzed coupling reactions
Sonogashira
Stille
Suzuki
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Zusammenfassung:A series of substituted tetralones as intermediates of CNS agents has been synthesized via Pd-catalyzed coupling reactions of 3-(methoxycarbonyl)-1,2,3,4-tetrahydro-1-oxonaphthalen-6-yl trifluoromethanesulfonate ( 5) with a variety of organometallic reagents.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2006.10.154