tRNA and protein methylase complexes mediate zymocin toxicity in yeast

Modification of Saccharomyces cerevisiae tRNA anticodons at the wobble uridine (U34) position is required for tRNA cleavage by the zymocin tRNase killer toxin from Kluyveromyces lactis. Hence, U34 modification defects including lack of the U34 tRNA methyltransferase Trm9 protect against tRNA cleavag...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular microbiology 2008-09, Vol.69 (5), p.1266-1277
Hauptverfasser:	Studte, Patrick, Zink, Sabrina, Jablonowski, Daniel, Bär, Christian, von der Haar, Tobias, Tuite, Mick F, Schaffrath, Raffael
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticodon - genetics Anticodon - metabolism Biological and medical sciences Drug Resistance, Fungal Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Fungal Killer Factors, Yeast Kluyveromyces - metabolism Kluyveromyces lactis Microbiology Mutation Mycotoxins - pharmacology Peptide Termination Factors - genetics Peptide Termination Factors - metabolism Protein synthesis Proteins RNA, Transfer - genetics RNA, Transfer - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Suppression, Genetic Toxicity Transfer RNA tRNA Methyltransferases - chemistry tRNA Methyltransferases - genetics tRNA Methyltransferases - metabolism Uridine - genetics Uridine - metabolism Yeast
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!