Inhibition of fipronil and nonane metabolism in human liver microsomes and human cytochrome P450 isoforms by chlorpyrifos

Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study the effect of e...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2007-04, Vol.21 (2), p.76-80
Hauptverfasser:	Joo, Hyun, Choi, Kyoungju, Rose, Randy L., Hodgson, Ernest
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanes - pharmacology Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Aryl Hydrocarbon Hydroxylases - metabolism Chlorpyrifos - pharmacology CYP2B6 CYP3A4 Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Enzyme Activation - drug effects Female Fipronil Human Liver Microsomes Humans Insecticides - pharmacology Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Male Microsomes, Liver - enzymology Nonane Oxidoreductases, N-Demethylating - antagonists & inhibitors Oxidoreductases, N-Demethylating - metabolism Pyrazoles - pharmacology
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