Comparison of fathead minnow ovary explant and H295R cell-based steroidogenesis assays for identifying endocrine-active chemicals

An in vitro steroidogenesis assay using H295R human adenocarcinoma cells has been suggested as a possible alternative to gonad explant assays for use as a Tier I screening assay to detect endocrine active chemicals capable of modulating steroid hormone synthesis. This study is one of the first to in...

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Veröffentlicht in:	Ecotoxicology and environmental safety 2007-09, Vol.68 (1), p.20-32
Hauptverfasser:	Villeneuve, Daniel L., Ankley, Gerald T., Makynen, Elizabeth A., Blake, Lindsey S., Greene, Katie J., Higley, Eric B., Newsted, John L., Giesy, John P., Hecker, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - metabolism Adrenal Gland Neoplasms - drug therapy Adrenal Gland Neoplasms - metabolism Animal and plant ecology Animal Testing Alternatives Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Biological Assay Cell Line, Tumor Cyprinidae Dose-Response Relationship, Drug Ecotoxicology, biological effects of pollution Endocrine disruption Estradiol - biosynthesis Fadrozole Female Fresh water ecosystems Freshwater Fundamental and applied biological sciences. Psychology Fungicides General aspects Hormone Antagonists - classification Hormone Antagonists - toxicity Hormone synthesis Humans Organ Culture Techniques Ovary - drug effects Ovary - metabolism Prometon Reproducibility of Results Steroid hormones Synecology Testosterone - biosynthesis
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