Antifungal substances isolated from Aspergillus fumigatus IFM 54246, obtained from a Brasilian soil

In the screening for new antifungal substances against pathogenic filamentous fungi and yeasts, a naturally new compound, 2,4-dihydroxy-3-methylacetophenone (2), was isolated along with tryptoquivaline I (1) from the methylene chloride-methanol (1:1) extract of Aspergillus fumigatus IFM 54246, obtained from a Brasilian soil, screened by possessing the antifungal activity against Aspergillus fumigatus, Aspergillus niger, Candida albicans and Cryptococcus neoformans. The structure of 2 was determined from the analysis of the spectroscopic investigation. Compound 2 showed the broad antifungal activity against A. fumigatus, A. niger, C. albicans, and C. neoformans, whereas tryptoquivaline I (1) showed the inhibition only against A. fumigatus. The main antifungal substance in the extract of the A. fumigatus strain was considered to be compound 2.