Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: Modification of vaccine-induced immune responses
Summary Lipopolysaccharide (LPS) is one of the main constituents of the Gram-negative bacterial outer membrane. Besides being an endotoxin, LPS also possesses a powerful adjuvant activity. Previously, it has been shown that changes in the chemical composition of the lipid A domain of LPS modulate it...
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| Veröffentlicht in: | Vaccine 2008-02, Vol.26 (7), p.899-906 |
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| creator | Geurtsen, Jeroen Fransen, Floris Vandebriel, Rob J Gremmer, Eric R de la Fonteyne-Blankestijn, Liset J.J Kuipers, Betsy Tommassen, Jan van der Ley, Peter |
| description | Summary Lipopolysaccharide (LPS) is one of the main constituents of the Gram-negative bacterial outer membrane. Besides being an endotoxin, LPS also possesses a powerful adjuvant activity. Previously, it has been shown that changes in the chemical composition of the lipid A domain of LPS modulate its biological activity. For example, monophosphoryl lipid A (MPL) has been shown to be a non-toxic immunostimulatory compound. Moreover, several LPS analogs have been shown to antagonise LPS-induced signalling in eukaryotic cells. In the present study, we show that supplementation of a whole-cell pertussis (wP) vaccine with LPS analogs modulates the vaccine-induced immune responses. We show in a mouse-model system that addition of MPL to a wP vaccine increases vaccine efficacy without altering vaccine-induced serum pro-inflammatory cytokine levels. Furthermore, we show that Neisseria meningitidis LpxL2 LPS, an LPS species derived from a N. meningitidis lpxL2 mutant, antagonises wP and LPS-stimulated interleukin-6 (IL-6) production by macrophages in vitro, and that addition of this LPS-derivative to the wP vaccine decreases vaccine-induced serum IL-6 levels and increases vaccine efficacy. |
| doi_str_mv | 10.1016/j.vaccine.2007.12.012 |
| format | Article |
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Besides being an endotoxin, LPS also possesses a powerful adjuvant activity. Previously, it has been shown that changes in the chemical composition of the lipid A domain of LPS modulate its biological activity. For example, monophosphoryl lipid A (MPL) has been shown to be a non-toxic immunostimulatory compound. Moreover, several LPS analogs have been shown to antagonise LPS-induced signalling in eukaryotic cells. In the present study, we show that supplementation of a whole-cell pertussis (wP) vaccine with LPS analogs modulates the vaccine-induced immune responses. We show in a mouse-model system that addition of MPL to a wP vaccine increases vaccine efficacy without altering vaccine-induced serum pro-inflammatory cytokine levels. Furthermore, we show that Neisseria meningitidis LpxL2 LPS, an LPS species derived from a N. meningitidis lpxL2 mutant, antagonises wP and LPS-stimulated interleukin-6 (IL-6) production by macrophages in vitro, and that addition of this LPS-derivative to the wP vaccine decreases vaccine-induced serum IL-6 levels and increases vaccine efficacy.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2007.12.012</identifier><identifier>PMID: 18207288</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Adjuvants, Immunologic - chemistry ; Allergy and Immunology ; Animals ; Antibodies, Bacterial - blood ; Antigens ; Applied microbiology ; Bacterial diseases ; Bacteriology ; Biological and medical sciences ; Bordetella pertussis ; Bordetella pertussis - immunology ; Cell Line ; Cytokines - metabolism ; Endotoxins ; Ent and stomatologic bacterial diseases ; Female ; Fundamental and applied biological sciences. Psychology ; Human bacterial diseases ; Infections ; Infectious diseases ; Interleukin-6 - metabolism ; Lipid A - administration & dosage ; Lipid A - analogs & derivatives ; Lipid A - chemistry ; Lipid A - immunology ; Lipids ; Lipopolysaccharide ; Lipopolysaccharides - administration & dosage ; Lipopolysaccharides - chemistry ; Lipopolysaccharides - immunology ; Lipopolysaccharides - metabolism ; LpxL2 ; Lung - immunology ; Lung - microbiology ; Lungs ; Macrophage Activation ; Macrophages - immunology ; Medical sciences ; Mice ; Microbiology ; Miscellaneous ; Monophosphoryl lipid A ; Neisseria meningitidis ; Neisseria meningitidis - immunology ; Neisseria meningitidis - metabolism ; Pertussis Vaccine - administration & dosage ; Pertussis Vaccine - immunology ; Treatment Outcome ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Whole-cell pertussis vaccines ; Whooping cough ; Whooping Cough - immunology ; Whooping Cough - microbiology</subject><ispartof>Vaccine, 2008-02, Vol.26 (7), p.899-906</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Feb 13, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-e344b999528e1acbcff7b3c277bc613f641229b0f0d0d37ac32ea11241c8f4273</citedby><cites>FETCH-LOGICAL-c507t-e344b999528e1acbcff7b3c277bc613f641229b0f0d0d37ac32ea11241c8f4273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1558808557?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20043504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18207288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geurtsen, Jeroen</creatorcontrib><creatorcontrib>Fransen, Floris</creatorcontrib><creatorcontrib>Vandebriel, Rob J</creatorcontrib><creatorcontrib>Gremmer, Eric R</creatorcontrib><creatorcontrib>de la Fonteyne-Blankestijn, Liset J.J</creatorcontrib><creatorcontrib>Kuipers, Betsy</creatorcontrib><creatorcontrib>Tommassen, Jan</creatorcontrib><creatorcontrib>van der Ley, Peter</creatorcontrib><title>Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: Modification of vaccine-induced immune responses</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Summary Lipopolysaccharide (LPS) is one of the main constituents of the Gram-negative bacterial outer membrane. Besides being an endotoxin, LPS also possesses a powerful adjuvant activity. Previously, it has been shown that changes in the chemical composition of the lipid A domain of LPS modulate its biological activity. For example, monophosphoryl lipid A (MPL) has been shown to be a non-toxic immunostimulatory compound. Moreover, several LPS analogs have been shown to antagonise LPS-induced signalling in eukaryotic cells. In the present study, we show that supplementation of a whole-cell pertussis (wP) vaccine with LPS analogs modulates the vaccine-induced immune responses. We show in a mouse-model system that addition of MPL to a wP vaccine increases vaccine efficacy without altering vaccine-induced serum pro-inflammatory cytokine levels. Furthermore, we show that Neisseria meningitidis LpxL2 LPS, an LPS species derived from a N. meningitidis lpxL2 mutant, antagonises wP and LPS-stimulated interleukin-6 (IL-6) production by macrophages in vitro, and that addition of this LPS-derivative to the wP vaccine decreases vaccine-induced serum IL-6 levels and increases vaccine efficacy.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Adjuvants, Immunologic - chemistry</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigens</subject><subject>Applied microbiology</subject><subject>Bacterial diseases</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Bordetella pertussis</subject><subject>Bordetella pertussis - immunology</subject><subject>Cell Line</subject><subject>Cytokines - metabolism</subject><subject>Endotoxins</subject><subject>Ent and stomatologic bacterial diseases</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human bacterial diseases</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Interleukin-6 - metabolism</subject><subject>Lipid A - administration & dosage</subject><subject>Lipid A - analogs & derivatives</subject><subject>Lipid A - chemistry</subject><subject>Lipid A - immunology</subject><subject>Lipids</subject><subject>Lipopolysaccharide</subject><subject>Lipopolysaccharides - administration & dosage</subject><subject>Lipopolysaccharides - chemistry</subject><subject>Lipopolysaccharides - immunology</subject><subject>Lipopolysaccharides - metabolism</subject><subject>LpxL2</subject><subject>Lung - immunology</subject><subject>Lung - microbiology</subject><subject>Lungs</subject><subject>Macrophage Activation</subject><subject>Macrophages - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Monophosphoryl lipid A</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - immunology</subject><subject>Neisseria meningitidis - metabolism</subject><subject>Pertussis Vaccine - administration & dosage</subject><subject>Pertussis Vaccine - immunology</subject><subject>Treatment Outcome</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Whole-cell pertussis vaccines</subject><subject>Whooping cough</subject><subject>Whooping Cough - immunology</subject><subject>Whooping Cough - microbiology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk2L1TAYhYsozvXqT1AKorvWfDRNrwtFBr9gxMUouAtp-taba5p08rYz3K2_3JRbZmA2LkIgPOck5z3JsueUlJTQ-s2hvNbGWA8lI0SWlJWEsgfZhjaSF0zQ5mG2IayuioqSX2fZE8QDIURwunucndGGEcmaZpP9vZzH0cEAftKTDT4PfX6zDw4KA87lI8RpRrSYr7dhfmOnfe7sGMbgjphO9zraDnLttQu_8W3-LXS2t-bWblUW1nezgS63wzB7yCPgGDwCPs0e9dohPFv3bfbz08cf51-Ki--fv55_uCiMIHIqgFdVu9vtBGuAatOavpctN0zK1tSU93VFGdu1pCcd6bjUhjPQlLKKmqavmOTb7PXJd4zhagac1GBxSak9hBkVo0SwmvMEvrwHHsIcUzxUVIimIY0Qi504USYGxAi9GqMddDwqStRSkTqoNbpaKlKUqVRR0r1Y3ed2gO5OtXaSgFcroNFo10ftjcVbLnlVXKS1zd6fOEhDu7YQFRoLPo3YRjCT6oL971Pe3XMwzvpUnfsDR8C71AqTQF0u_2n5TkQSWsm64v8AB3PJTg</recordid><startdate>20080213</startdate><enddate>20080213</enddate><creator>Geurtsen, Jeroen</creator><creator>Fransen, Floris</creator><creator>Vandebriel, Rob J</creator><creator>Gremmer, Eric R</creator><creator>de la Fonteyne-Blankestijn, Liset J.J</creator><creator>Kuipers, Betsy</creator><creator>Tommassen, Jan</creator><creator>van der Ley, Peter</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20080213</creationdate><title>Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: Modification of vaccine-induced immune responses</title><author>Geurtsen, Jeroen ; Fransen, Floris ; Vandebriel, Rob J ; Gremmer, Eric R ; de la Fonteyne-Blankestijn, Liset J.J ; Kuipers, Betsy ; Tommassen, Jan ; van der Ley, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-e344b999528e1acbcff7b3c277bc613f641229b0f0d0d37ac32ea11241c8f4273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Adjuvants, Immunologic - chemistry</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigens</topic><topic>Applied microbiology</topic><topic>Bacterial diseases</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Bordetella pertussis</topic><topic>Bordetella pertussis - immunology</topic><topic>Cell Line</topic><topic>Cytokines - metabolism</topic><topic>Endotoxins</topic><topic>Ent and stomatologic bacterial diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human bacterial diseases</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Interleukin-6 - metabolism</topic><topic>Lipid A - administration & dosage</topic><topic>Lipid A - analogs & derivatives</topic><topic>Lipid A - chemistry</topic><topic>Lipid A - immunology</topic><topic>Lipids</topic><topic>Lipopolysaccharide</topic><topic>Lipopolysaccharides - administration & dosage</topic><topic>Lipopolysaccharides - chemistry</topic><topic>Lipopolysaccharides - immunology</topic><topic>Lipopolysaccharides - metabolism</topic><topic>LpxL2</topic><topic>Lung - immunology</topic><topic>Lung - microbiology</topic><topic>Lungs</topic><topic>Macrophage Activation</topic><topic>Macrophages - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Monophosphoryl lipid A</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - immunology</topic><topic>Neisseria meningitidis - metabolism</topic><topic>Pertussis Vaccine - administration & dosage</topic><topic>Pertussis Vaccine - immunology</topic><topic>Treatment Outcome</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Whole-cell pertussis vaccines</topic><topic>Whooping cough</topic><topic>Whooping Cough - immunology</topic><topic>Whooping Cough - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geurtsen, Jeroen</creatorcontrib><creatorcontrib>Fransen, Floris</creatorcontrib><creatorcontrib>Vandebriel, Rob J</creatorcontrib><creatorcontrib>Gremmer, Eric R</creatorcontrib><creatorcontrib>de la Fonteyne-Blankestijn, Liset J.J</creatorcontrib><creatorcontrib>Kuipers, Betsy</creatorcontrib><creatorcontrib>Tommassen, Jan</creatorcontrib><creatorcontrib>van der Ley, 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responses</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2008-02-13</date><risdate>2008</risdate><volume>26</volume><issue>7</issue><spage>899</spage><epage>906</epage><pages>899-906</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Summary Lipopolysaccharide (LPS) is one of the main constituents of the Gram-negative bacterial outer membrane. Besides being an endotoxin, LPS also possesses a powerful adjuvant activity. Previously, it has been shown that changes in the chemical composition of the lipid A domain of LPS modulate its biological activity. For example, monophosphoryl lipid A (MPL) has been shown to be a non-toxic immunostimulatory compound. Moreover, several LPS analogs have been shown to antagonise LPS-induced signalling in eukaryotic cells. In the present study, we show that supplementation of a whole-cell pertussis (wP) vaccine with LPS analogs modulates the vaccine-induced immune responses. We show in a mouse-model system that addition of MPL to a wP vaccine increases vaccine efficacy without altering vaccine-induced serum pro-inflammatory cytokine levels. Furthermore, we show that Neisseria meningitidis LpxL2 LPS, an LPS species derived from a N. meningitidis lpxL2 mutant, antagonises wP and LPS-stimulated interleukin-6 (IL-6) production by macrophages in vitro, and that addition of this LPS-derivative to the wP vaccine decreases vaccine-induced serum IL-6 levels and increases vaccine efficacy.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18207288</pmid><doi>10.1016/j.vaccine.2007.12.012</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vaccine, 2008-02, Vol.26 (7), p.899-906 |
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| subjects | Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - chemistry Allergy and Immunology Animals Antibodies, Bacterial - blood Antigens Applied microbiology Bacterial diseases Bacteriology Biological and medical sciences Bordetella pertussis Bordetella pertussis - immunology Cell Line Cytokines - metabolism Endotoxins Ent and stomatologic bacterial diseases Female Fundamental and applied biological sciences. Psychology Human bacterial diseases Infections Infectious diseases Interleukin-6 - metabolism Lipid A - administration & dosage Lipid A - analogs & derivatives Lipid A - chemistry Lipid A - immunology Lipids Lipopolysaccharide Lipopolysaccharides - administration & dosage Lipopolysaccharides - chemistry Lipopolysaccharides - immunology Lipopolysaccharides - metabolism LpxL2 Lung - immunology Lung - microbiology Lungs Macrophage Activation Macrophages - immunology Medical sciences Mice Microbiology Miscellaneous Monophosphoryl lipid A Neisseria meningitidis Neisseria meningitidis - immunology Neisseria meningitidis - metabolism Pertussis Vaccine - administration & dosage Pertussis Vaccine - immunology Treatment Outcome Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Whole-cell pertussis vaccines Whooping cough Whooping Cough - immunology Whooping Cough - microbiology |
| title | Supplementation of whole-cell pertussis vaccines with lipopolysaccharide analogs: Modification of vaccine-induced immune responses |
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