TRPs in Our Senses
In the last decade, studies of transient receptor potential (TRP) channels, a superfamily of cation-conducting membrane proteins, have significantly extended our knowledge about the molecular basis of sensory perception in animals. Due to their distinct activation mechanisms and biophysical properti...
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| Veröffentlicht in: | Current biology 2008-09, Vol.18 (18), p.R880-R889 |
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| container_title | Current biology |
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| creator | Damann, Nils Voets, Thomas Nilius, Bernd |
| description | In the last decade, studies of transient receptor potential (TRP) channels, a superfamily of cation-conducting membrane proteins, have significantly extended our knowledge about the molecular basis of sensory perception in animals. Due to their distinct activation mechanisms and biophysical properties, TRP channels are highly suited to function in receptor cells, either as receptors for environmental or endogenous stimuli or as molecular players in signal transduction cascades downstream of metabotropic receptors. As such, TRP channels play a crucial role in many mammalian senses, including touch, taste and smell. Starting with a brief survey of sensory TRP channels in invertebrate model systems, this review covers the current state of research on TRP channel function in the classical mammalian senses and summarizes how modulation of TRP channels can tune our sensations. |
| doi_str_mv | 10.1016/j.cub.2008.07.063 |
| format | Article |
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| ispartof | Current biology, 2008-09, Vol.18 (18), p.R880-R889 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - physiology Chemoreceptor Cells - physiology Color Perception - physiology Drosophila - physiology Drosophila Proteins - physiology Hearing - physiology Humans Mammals Mechanoreceptors - physiology Perception - physiology Photoreceptor Cells - physiology Receptors, Cell Surface Sensation - physiology Smell - physiology Touch - physiology Transient Receptor Potential Channels - physiology |
| title | TRPs in Our Senses |
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