Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

In response to infection, naïve CD4 T cells differentiate into two subpopulations: T follicular helper (T ) cells, which support B cell antibody production, and non-T cells, which enhance innate immune cell functions. Interleukin-2 (IL-2), the major cytokine produced by naïve T cells, plays an impor...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-09, Vol.361 (6407)
Hauptverfasser:	DiToro, Daniel, Winstead, Colleen J, Pham, Duy, Witte, Steven, Andargachew, Rakieb, Singer, Jeffrey R, Wilson, C Garrett, Zindl, Carlene L, Luther, Rita J, Silberger, Daniel J, Weaver, Benjamin T, Kolawole, E Motunrayo, Martinez, Ryan J, Turner, Henrietta, Hatton, Robin D, Moon, James J, Way, Sing Sing, Evavold, Brian D, Weaver, Casey T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive systems Animals Antibodies Antigens Bcl-6 protein Bifurcations CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell fate Chromatin - metabolism Clonal deletion Cytokines Developmental Programs Differentiation Divergence Effector cells Egress Gene Expression Gene sequencing Genes, Reporter Growth factors Helper cells Immune system Immunological memory Immunology In vivo methods and tests Individualized Instruction Innate immunity Interleukin 2 Interleukin 2 receptors Interleukin-2 - genetics Lymphocyte Activation - genetics Lymphocytes Lymphocytes B Lymphocytes T Lymphoid tissue Mice Mice, Transgenic Paracrine signalling Pathogens Phenotypes Proto-Oncogene Proteins c-bcl-2 - genetics Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Ribonucleic acid RNA Signal strength Stat5 protein Subpopulations T cell receptors T-Lymphocytes, Helper-Inducer - immunology Tissues Transcription Factors - metabolism
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