Asymmetric phosphoric acid-catalyzed four-component Ugi reaction

The Ugi reaction constructs α-acylaminoamide compounds by combining an aldehyde or ketone, an amine, a carboxylic acid, and an isocyanide in a single flask. Its appealing features include inherent atom and step economy together with the potential to generate products of broad structural diversity. H...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-09, Vol.361 (6407)
Hauptverfasser:	Zhang, Jian, Yu, Peiyuan, Li, Shao-Yu, Sun, He, Xiang, Shao-Hua, Wang, Jun Joelle, Houk, Kendall N, Tan, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidity Acids Activation energy Aromatic compounds Asymmetry Atom economy Carbonyl compounds Carbonyl groups Carbonyls Carboxylic acids Catalysis Catalysts Chemical synthesis Chemistry Computer applications Coupling (molecular) Density functional theory Drug discovery Enantiomers Exploration Free energy Harnesses Hydrogen bonding Kinetics Libraries Mathematical analysis Natural products Organic chemistry Peptides Phosphoric acid Polymers Proteins Reaction kinetics Side reactions Steering Stereochemistry Stereoselectivity Substrates
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!