Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women
Obesity is related to many major diseases and cancers. Women have higher rates of obesity and obesity is linked to commonly occurring cancers in women. However, there is a lack of knowledge of the unique mechanism(s) involved in each type of cancer. The objective of this review is to highlight the n...
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| Veröffentlicht in: | Endocrine 2019-01, Vol.63 (1), p.3-17 |
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| creator | Nyasani, Eunice Munir, Iqbal Perez, Mia Payne, Kimberly Khan, Salma |
| description | Obesity is related to many major diseases and cancers. Women have higher rates of obesity and obesity is linked to commonly occurring cancers in women. However, there is a lack of knowledge of the unique mechanism(s) involved in each type of cancer. The objective of this review is to highlight the need for novel experimental approaches and a better understanding of the common and unique pathways to resolve controversies regarding the role of obesity in cancer. In women, there is a link between hormones and obesity-associated genes in cancer development. Leptin is an obesity-associated gene that has been studied extensively in cancers; however, whether the defect is in the leptin gene or in its signaling pathways remains unclear. Both leptin and its receptor have been positively correlated with cancer progression in some endocrine-related cancers in women. This review offers an up-to-date and cohesive review of both upstream and downstream pathways of leptin signaling in cancer and a comprehensive picture of cancer pathogenesis in light of current evidence of leptin effects in several major types of cancer. This work is intended to aid in the design of better therapeutic strategies for obese/overweight women with cancer. |
| doi_str_mv | 10.1007/s12020-018-1748-4 |
| format | Article |
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Women have higher rates of obesity and obesity is linked to commonly occurring cancers in women. However, there is a lack of knowledge of the unique mechanism(s) involved in each type of cancer. The objective of this review is to highlight the need for novel experimental approaches and a better understanding of the common and unique pathways to resolve controversies regarding the role of obesity in cancer. In women, there is a link between hormones and obesity-associated genes in cancer development. Leptin is an obesity-associated gene that has been studied extensively in cancers; however, whether the defect is in the leptin gene or in its signaling pathways remains unclear. Both leptin and its receptor have been positively correlated with cancer progression in some endocrine-related cancers in women. This review offers an up-to-date and cohesive review of both upstream and downstream pathways of leptin signaling in cancer and a comprehensive picture of cancer pathogenesis in light of current evidence of leptin effects in several major types of cancer. This work is intended to aid in the design of better therapeutic strategies for obese/overweight women with cancer.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-018-1748-4</identifier><identifier>PMID: 30218381</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Body weight ; Cancer ; Diabetes ; Endocrine Gland Neoplasms - epidemiology ; Endocrine Gland Neoplasms - etiology ; Endocrine Gland Neoplasms - metabolism ; Endocrine Gland Neoplasms - therapy ; Endocrinology ; Female ; Humanities and Social Sciences ; Humans ; Internal Medicine ; Leptin ; Leptin - metabolism ; Medicine ; Medicine & Public Health ; multidisciplinary ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Obesity - metabolism ; Overweight ; Receptors, Leptin - metabolism ; Review ; Reviews ; Science ; Sex Factors ; Signal transduction ; Signal Transduction - physiology</subject><ispartof>Endocrine, 2019-01, Vol.63 (1), p.3-17</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c324t-9ecb205d23ed2b1d2f7076cb1b0dbe3d49d1a1f180446af92b7f4dc80784f66d3</cites><orcidid>0000-0003-2564-4358</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-018-1748-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-018-1748-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30218381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nyasani, Eunice</creatorcontrib><creatorcontrib>Munir, Iqbal</creatorcontrib><creatorcontrib>Perez, Mia</creatorcontrib><creatorcontrib>Payne, Kimberly</creatorcontrib><creatorcontrib>Khan, Salma</creatorcontrib><title>Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Obesity is related to many major diseases and cancers. Women have higher rates of obesity and obesity is linked to commonly occurring cancers in women. However, there is a lack of knowledge of the unique mechanism(s) involved in each type of cancer. The objective of this review is to highlight the need for novel experimental approaches and a better understanding of the common and unique pathways to resolve controversies regarding the role of obesity in cancer. In women, there is a link between hormones and obesity-associated genes in cancer development. Leptin is an obesity-associated gene that has been studied extensively in cancers; however, whether the defect is in the leptin gene or in its signaling pathways remains unclear. Both leptin and its receptor have been positively correlated with cancer progression in some endocrine-related cancers in women. This review offers an up-to-date and cohesive review of both upstream and downstream pathways of leptin signaling in cancer and a comprehensive picture of cancer pathogenesis in light of current evidence of leptin effects in several major types of cancer. 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Women have higher rates of obesity and obesity is linked to commonly occurring cancers in women. However, there is a lack of knowledge of the unique mechanism(s) involved in each type of cancer. The objective of this review is to highlight the need for novel experimental approaches and a better understanding of the common and unique pathways to resolve controversies regarding the role of obesity in cancer. In women, there is a link between hormones and obesity-associated genes in cancer development. Leptin is an obesity-associated gene that has been studied extensively in cancers; however, whether the defect is in the leptin gene or in its signaling pathways remains unclear. Both leptin and its receptor have been positively correlated with cancer progression in some endocrine-related cancers in women. 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| subjects | Body weight Cancer Diabetes Endocrine Gland Neoplasms - epidemiology Endocrine Gland Neoplasms - etiology Endocrine Gland Neoplasms - metabolism Endocrine Gland Neoplasms - therapy Endocrinology Female Humanities and Social Sciences Humans Internal Medicine Leptin Leptin - metabolism Medicine Medicine & Public Health multidisciplinary Obesity Obesity - complications Obesity - epidemiology Obesity - metabolism Overweight Receptors, Leptin - metabolism Review Reviews Science Sex Factors Signal transduction Signal Transduction - physiology |
| title | Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women |
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