Discovery of DS42450411 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4-aminopyrimidine derivatives

[Display omitted] •Hepcidin, a peptide hormone, is a master regulator of systemic iron mobilizations (83 characters).•Hepcidin inhibition could be a strategy for treating anemia of chronic disease (80 characters).•4-Aminopyrimidine compound was founded as a hit of Hepcidin production inhibitor (82 c...

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