Exploring cellular fatty acid composition and intracellular metabolites of osmotic-tolerant mutant Lactobacillus paracasei NCBIO-M2 for highly efficient lactic acid production with high initial glucose concentration

•An osmotic-tolerant mutant was obtained by high-throughput screening technology.•Fatty acid composition and intermediates contributed to improve osmotic tolerance.•248 g/L glucose was totally consumed by neutralizing agent combination strategy.•223.7 g/L lactic acid was produced with an overall pro...

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Veröffentlicht in:	Journal of biotechnology 2018-11, Vol.286, p.27-35
Hauptverfasser:	Tian, Xiwei, Wang, Yonghong, Chu, Ju, Mohsin, Ali, Zhuang, Yingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Batch Cell Culture Techniques Bioreactors - microbiology Fatty acid Fatty Acids - analysis Fermentation Glucose - metabolism Intracellular metabolite Lactic acid Lactic Acid - metabolism Lactobacillus paracasei Lactobacillus paracasei - genetics Lactobacillus paracasei - growth & development Lactobacillus paracasei - isolation & purification Lactobacillus paracasei - metabolism Metabolome Mutation Osmotic Pressure
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