Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney
: Cinnamaldehyde, a food flavour, has a high potential for human consumption in India. In this study, we evaluated the effect of cinnamaldehyde on the antioxidant status of the rat kidney. Rats were given cinnamaldehyde orally by gavage at dose levels of 2.14, 6.96, 22.62 and 73.5 mg/kg body weight/...
Gespeichert in:
| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2006-11, Vol.99 (5), p.379-382 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 382 |
|---|---|
| container_issue | 5 |
| container_start_page | 379 |
| container_title | Basic & clinical pharmacology & toxicology |
| container_volume | 99 |
| creator | Gowder, Sivakumar J. T. Devaraj, H. |
| description | : Cinnamaldehyde, a food flavour, has a high potential for human consumption in India. In this study, we evaluated the effect of cinnamaldehyde on the antioxidant status of the rat kidney. Rats were given cinnamaldehyde orally by gavage at dose levels of 2.14, 6.96, 22.62 and 73.5 mg/kg body weight/day for the period of 10, 30 and 90 days. The non‐enzymatic antioxidants ascorbic acid, α‐tocopherol and reduced glutathione were decreased while the antioxidant enzymes, superoxide dismutase, glutathione peroxidase and glutathione‐s‐transferase were increased. Catalase was decreased and thiobarbituric acid‐reactive substances were increased only in the kidney of rats treated with cinnamaldehyde at the dose level of 73.5 mg/kg body weight/day during an exposure period of 90 days and not in the kidney of other cinnamaldehyde‐treated rat groups. Thus, cinnamaldehyde has an effect on the antioxidant status of rat kidney and its effect is time‐ and dose‐dependent. |
| doi_str_mv | 10.1111/j.1742-7843.2006.pto_560.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_21048232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21048232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4860-d1b7588772b00578a4fb917737fd00c7a79124d3e0483835edb6757ebae71ed03</originalsourceid><addsrcrecordid>eNqVkE1P4zAQhi3EikKXv7CKVmJvDWM7yaRcEFu1gKjEfpSz5cQTkSqNS-zstv-eZBuV8_oyI_l57ZmHsa8cQt6d63XIMRITTCMZCoAk3Hqr4gTC3Qk7P16dHnsZj9iFc2sAgRGHMzbiCJgkU37Ofs6LgnIf2CLwrxQsrDXBotJ_bNsEs7Ku9UZXhl73hgJb_0Pual_aXWl07YPfXvvW9eFf2gdPpalp_5l9KnTl6HKoY_aymK9mD5Pl8_3j7G45yaM0gYnhGcZpiigygBhTHRXZlCNKLAxAjhqnXERGEkSp7FYgkyUYI2WakJMBOWbfDu9uG_vWkvNqU7qcqkrXZFunBO-SQooOvDmAeWOda6hQ26bc6GavOKheqFqr3pTqraleqBqEql0X_jL80mYbMh_RwWAHXA2AdrmuikbXeek-uFQkEqJ-itsD97esaP8fI6jvsx-rrpPvK9iS2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21048232</pqid></control><display><type>article</type><title>Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Alma/SFX Local Collection</source><creator>Gowder, Sivakumar J. T. ; Devaraj, H.</creator><creatorcontrib>Gowder, Sivakumar J. T. ; Devaraj, H.</creatorcontrib><description>: Cinnamaldehyde, a food flavour, has a high potential for human consumption in India. In this study, we evaluated the effect of cinnamaldehyde on the antioxidant status of the rat kidney. Rats were given cinnamaldehyde orally by gavage at dose levels of 2.14, 6.96, 22.62 and 73.5 mg/kg body weight/day for the period of 10, 30 and 90 days. The non‐enzymatic antioxidants ascorbic acid, α‐tocopherol and reduced glutathione were decreased while the antioxidant enzymes, superoxide dismutase, glutathione peroxidase and glutathione‐s‐transferase were increased. Catalase was decreased and thiobarbituric acid‐reactive substances were increased only in the kidney of rats treated with cinnamaldehyde at the dose level of 73.5 mg/kg body weight/day during an exposure period of 90 days and not in the kidney of other cinnamaldehyde‐treated rat groups. Thus, cinnamaldehyde has an effect on the antioxidant status of rat kidney and its effect is time‐ and dose‐dependent.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/j.1742-7843.2006.pto_560.x</identifier><identifier>PMID: 17076691</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Acrolein - analogs & derivatives ; Acrolein - toxicity ; Administration, Oral ; alpha-Tocopherol - metabolism ; Animals ; Antioxidants - metabolism ; Ascorbic Acid - metabolism ; Biological and medical sciences ; Catalase - metabolism ; Dose-Response Relationship, Drug ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Glutathione Transferase - metabolism ; Kidney - drug effects ; Kidney - metabolism ; Male ; Medical sciences ; Oxidative Stress - drug effects ; Peroxidase - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Basic & clinical pharmacology & toxicology, 2006-11, Vol.99 (5), p.379-382</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4860-d1b7588772b00578a4fb917737fd00c7a79124d3e0483835edb6757ebae71ed03</citedby><cites>FETCH-LOGICAL-c4860-d1b7588772b00578a4fb917737fd00c7a79124d3e0483835edb6757ebae71ed03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1742-7843.2006.pto_560.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1742-7843.2006.pto_560.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18263042$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17076691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gowder, Sivakumar J. T.</creatorcontrib><creatorcontrib>Devaraj, H.</creatorcontrib><title>Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney</title><title>Basic & clinical pharmacology & toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>: Cinnamaldehyde, a food flavour, has a high potential for human consumption in India. In this study, we evaluated the effect of cinnamaldehyde on the antioxidant status of the rat kidney. Rats were given cinnamaldehyde orally by gavage at dose levels of 2.14, 6.96, 22.62 and 73.5 mg/kg body weight/day for the period of 10, 30 and 90 days. The non‐enzymatic antioxidants ascorbic acid, α‐tocopherol and reduced glutathione were decreased while the antioxidant enzymes, superoxide dismutase, glutathione peroxidase and glutathione‐s‐transferase were increased. Catalase was decreased and thiobarbituric acid‐reactive substances were increased only in the kidney of rats treated with cinnamaldehyde at the dose level of 73.5 mg/kg body weight/day during an exposure period of 90 days and not in the kidney of other cinnamaldehyde‐treated rat groups. Thus, cinnamaldehyde has an effect on the antioxidant status of rat kidney and its effect is time‐ and dose‐dependent.</description><subject>Acrolein - analogs & derivatives</subject><subject>Acrolein - toxicity</subject><subject>Administration, Oral</subject><subject>alpha-Tocopherol - metabolism</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Catalase - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxidative Stress - drug effects</subject><subject>Peroxidase - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1P4zAQhi3EikKXv7CKVmJvDWM7yaRcEFu1gKjEfpSz5cQTkSqNS-zstv-eZBuV8_oyI_l57ZmHsa8cQt6d63XIMRITTCMZCoAk3Hqr4gTC3Qk7P16dHnsZj9iFc2sAgRGHMzbiCJgkU37Ofs6LgnIf2CLwrxQsrDXBotJ_bNsEs7Ku9UZXhl73hgJb_0Pual_aXWl07YPfXvvW9eFf2gdPpalp_5l9KnTl6HKoY_aymK9mD5Pl8_3j7G45yaM0gYnhGcZpiigygBhTHRXZlCNKLAxAjhqnXERGEkSp7FYgkyUYI2WakJMBOWbfDu9uG_vWkvNqU7qcqkrXZFunBO-SQooOvDmAeWOda6hQ26bc6GavOKheqFqr3pTqraleqBqEql0X_jL80mYbMh_RwWAHXA2AdrmuikbXeek-uFQkEqJ-itsD97esaP8fI6jvsx-rrpPvK9iS2w</recordid><startdate>200611</startdate><enddate>200611</enddate><creator>Gowder, Sivakumar J. T.</creator><creator>Devaraj, H.</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>200611</creationdate><title>Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney</title><author>Gowder, Sivakumar J. T. ; Devaraj, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4860-d1b7588772b00578a4fb917737fd00c7a79124d3e0483835edb6757ebae71ed03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Acrolein - analogs & derivatives</topic><topic>Acrolein - toxicity</topic><topic>Administration, Oral</topic><topic>alpha-Tocopherol - metabolism</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Ascorbic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Catalase - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxidative Stress - drug effects</topic><topic>Peroxidase - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gowder, Sivakumar J. T.</creatorcontrib><creatorcontrib>Devaraj, H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gowder, Sivakumar J. T.</au><au>Devaraj, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2006-11</date><risdate>2006</risdate><volume>99</volume><issue>5</issue><spage>379</spage><epage>382</epage><pages>379-382</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>: Cinnamaldehyde, a food flavour, has a high potential for human consumption in India. In this study, we evaluated the effect of cinnamaldehyde on the antioxidant status of the rat kidney. Rats were given cinnamaldehyde orally by gavage at dose levels of 2.14, 6.96, 22.62 and 73.5 mg/kg body weight/day for the period of 10, 30 and 90 days. The non‐enzymatic antioxidants ascorbic acid, α‐tocopherol and reduced glutathione were decreased while the antioxidant enzymes, superoxide dismutase, glutathione peroxidase and glutathione‐s‐transferase were increased. Catalase was decreased and thiobarbituric acid‐reactive substances were increased only in the kidney of rats treated with cinnamaldehyde at the dose level of 73.5 mg/kg body weight/day during an exposure period of 90 days and not in the kidney of other cinnamaldehyde‐treated rat groups. Thus, cinnamaldehyde has an effect on the antioxidant status of rat kidney and its effect is time‐ and dose‐dependent.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>17076691</pmid><doi>10.1111/j.1742-7843.2006.pto_560.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1742-7835 |
| ispartof | Basic & clinical pharmacology & toxicology, 2006-11, Vol.99 (5), p.379-382 |
| issn | 1742-7835 1742-7843 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21048232 |
| source | MEDLINE; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Acrolein - analogs & derivatives Acrolein - toxicity Administration, Oral alpha-Tocopherol - metabolism Animals Antioxidants - metabolism Ascorbic Acid - metabolism Biological and medical sciences Catalase - metabolism Dose-Response Relationship, Drug Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Transferase - metabolism Kidney - drug effects Kidney - metabolism Male Medical sciences Oxidative Stress - drug effects Peroxidase - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism |
| title | Effect of the Food Flavour Cinnamaldehyde on the Antioxidant Status of Rat Kidney |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A47%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20the%20Food%20Flavour%20Cinnamaldehyde%20on%20the%20Antioxidant%20Status%20of%20Rat%20Kidney&rft.jtitle=Basic%20&%20clinical%20pharmacology%20&%20toxicology&rft.au=Gowder,%20Sivakumar%20J.%20T.&rft.date=2006-11&rft.volume=99&rft.issue=5&rft.spage=379&rft.epage=382&rft.pages=379-382&rft.issn=1742-7835&rft.eissn=1742-7843&rft_id=info:doi/10.1111/j.1742-7843.2006.pto_560.x&rft_dat=%3Cproquest_cross%3E21048232%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21048232&rft_id=info:pmid/17076691&rfr_iscdi=true |