Short-term safety and pharmacodynamics of amdoxovir in HIV-infected patients

To evaluate the pharmacodynamics and safety of escalating doses of amdoxovir (DAPD) monotherapy administered to treatment-naive and experienced HIV-1-infected patients over 15 days. Ninety patients with plasma HIV-1 RNA levels between 5000 and 250,000 copies/ml were randomized to DAPD 25, 100, 200,...

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Veröffentlicht in:	AIDS (London) 2005-10, Vol.19 (15), p.1607-1615
Hauptverfasser:	THOMPSON, Melanie A, KESSLER, Harold A, ERON, Joseph J, JACOBSON, Jeffrey M, ADDA, Nathalie, GONG SHEN, JIAN ZONG, HARRIS, Jeanette, MOXHAM, Cary, ROUSSEAU, Franck S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - adverse effects Anti-HIV Agents - blood Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Biological and medical sciences Dioxolanes - administration & dosage Dioxolanes - adverse effects Dioxolanes - blood Dose-Response Relationship, Drug Female Genotype HIV Infections - blood HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - isolation & purification Human immunodeficiency virus 1 Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Linear Models Male Medical sciences Middle Aged Mutation Pharmacology. Drug treatments Purine Nucleosides - administration & dosage Purine Nucleosides - adverse effects Purine Nucleosides - blood Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - adverse effects Reverse Transcriptase Inhibitors - blood RNA, Viral - blood Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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