Environmental effect and genetic influence: a regional cancer predisposition survey in the Zonguldak region of Northwest Turkey
The Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and cal...
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| Veröffentlicht in: | Environmental earth sciences 2008-03, Vol.54 (2), p.391-409 |
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| creator | Kadir, Selahattin Önen-Hall, A. Piril Aydin, S. Nihal Yakicier, Cengiz Akarsu, Nurten Tuncer, Murat |
| description | The Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and calcite. Kaolinization, chloritization, sericitization, albitization, Fe-Ti-oxidation, and the presence of zeolite, epidote, and illite in andesitic rocks and tuffaceous materials developed as a result of the degradation of a glass shards matrix, enclosed feldspar, and clinopyroxene-type phenocrysts, due to alteration processes. The association of feldspar and glass with smectite and kaolinite, and the suborientation of feldspar-edged, subparallel kaolinite plates to fracture axes may exhibit an authigenic smectite or kaolinite. Increased alteration degree upward in which Al, Fe, and Ti are gained, and Si, Na, K, and Ca are depleted, is due to the alteration following possible diagenesis and hydrothermal activities. Micromorphologically, fibrous mordenite in the altered units and the presence of needle-type chrysotile in the residential buildings in which cancer cases lived were detected. In addition, the segregation pattern of cancer susceptibility in the region strongly suggested an environmental effect and a genetic influence on the increased cancer incidence in the region. The most likely diagnosis was Li-Fraumeni syndrome, which is one of the hereditary cancer predisposition syndromes; however, no mutations were observed in the p53 gene, which is the major cause of Li-Fraumeni syndrome. The micromorphology observed in the altered units in which cancer cases were detected may have a role in the expression of an unidentified gene, but does not explain alone the occurrence of cancer as a primary cause in the region. |
| doi_str_mv | 10.1007/s00254-007-0826-3 |
| format | Article |
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Piril ; Aydin, S. Nihal ; Yakicier, Cengiz ; Akarsu, Nurten ; Tuncer, Murat</creator><creatorcontrib>Kadir, Selahattin ; Önen-Hall, A. Piril ; Aydin, S. Nihal ; Yakicier, Cengiz ; Akarsu, Nurten ; Tuncer, Murat</creatorcontrib><description>The Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and calcite. Kaolinization, chloritization, sericitization, albitization, Fe-Ti-oxidation, and the presence of zeolite, epidote, and illite in andesitic rocks and tuffaceous materials developed as a result of the degradation of a glass shards matrix, enclosed feldspar, and clinopyroxene-type phenocrysts, due to alteration processes. The association of feldspar and glass with smectite and kaolinite, and the suborientation of feldspar-edged, subparallel kaolinite plates to fracture axes may exhibit an authigenic smectite or kaolinite. Increased alteration degree upward in which Al, Fe, and Ti are gained, and Si, Na, K, and Ca are depleted, is due to the alteration following possible diagenesis and hydrothermal activities. Micromorphologically, fibrous mordenite in the altered units and the presence of needle-type chrysotile in the residential buildings in which cancer cases lived were detected. In addition, the segregation pattern of cancer susceptibility in the region strongly suggested an environmental effect and a genetic influence on the increased cancer incidence in the region. The most likely diagnosis was Li-Fraumeni syndrome, which is one of the hereditary cancer predisposition syndromes; however, no mutations were observed in the p53 gene, which is the major cause of Li-Fraumeni syndrome. The micromorphology observed in the altered units in which cancer cases were detected may have a role in the expression of an unidentified gene, but does not explain alone the occurrence of cancer as a primary cause in the region.</description><identifier>ISSN: 0943-0105</identifier><identifier>ISSN: 1866-6280</identifier><identifier>EISSN: 1432-0495</identifier><identifier>EISSN: 1866-6299</identifier><identifier>DOI: 10.1007/s00254-007-0826-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Alteration minerals ; Analysis. Health state ; Biological and medical sciences ; Calcite ; Cancer ; Cretaceous ; Crystalline rocks ; Diagenesis ; Earth and Environmental Science ; Earth Sciences ; Earth, ocean, space ; Engineering and environment geology. Geothermics ; Environmental effects ; Environmental health ; Eocene ; Epidemiology ; Exact sciences and technology ; General aspects ; Genetic influence ; Genetics ; geochemistry ; Geology ; Health effects ; Igneous and metamorphic rocks petrology, volcanic processes, magmas ; Illite ; Kaolinite ; Medical sciences ; Mineralogy ; Morphology ; Original Article ; Pollution, environment geology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Residential areas ; Sandstone ; Sedimentary geology ; Turkey ; Volcanoes ; Volcanology ; Volcanosedimentary units ; Zonguldak</subject><ispartof>Environmental earth sciences, 2008-03, Vol.54 (2), p.391-409</ispartof><rights>Springer-Verlag 2007</rights><rights>2008 INIST-CNRS</rights><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-6139b1382efafbbf269208b6167244f0ad108c64c06b0aa3abe441cb961c2fe43</citedby><cites>FETCH-LOGICAL-c443t-6139b1382efafbbf269208b6167244f0ad108c64c06b0aa3abe441cb961c2fe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00254-007-0826-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00254-007-0826-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20328476$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadir, Selahattin</creatorcontrib><creatorcontrib>Önen-Hall, A. Piril</creatorcontrib><creatorcontrib>Aydin, S. Nihal</creatorcontrib><creatorcontrib>Yakicier, Cengiz</creatorcontrib><creatorcontrib>Akarsu, Nurten</creatorcontrib><creatorcontrib>Tuncer, Murat</creatorcontrib><title>Environmental effect and genetic influence: a regional cancer predisposition survey in the Zonguldak region of Northwest Turkey</title><title>Environmental earth sciences</title><addtitle>Environ Geol</addtitle><description>The Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and calcite. Kaolinization, chloritization, sericitization, albitization, Fe-Ti-oxidation, and the presence of zeolite, epidote, and illite in andesitic rocks and tuffaceous materials developed as a result of the degradation of a glass shards matrix, enclosed feldspar, and clinopyroxene-type phenocrysts, due to alteration processes. The association of feldspar and glass with smectite and kaolinite, and the suborientation of feldspar-edged, subparallel kaolinite plates to fracture axes may exhibit an authigenic smectite or kaolinite. Increased alteration degree upward in which Al, Fe, and Ti are gained, and Si, Na, K, and Ca are depleted, is due to the alteration following possible diagenesis and hydrothermal activities. Micromorphologically, fibrous mordenite in the altered units and the presence of needle-type chrysotile in the residential buildings in which cancer cases lived were detected. In addition, the segregation pattern of cancer susceptibility in the region strongly suggested an environmental effect and a genetic influence on the increased cancer incidence in the region. The most likely diagnosis was Li-Fraumeni syndrome, which is one of the hereditary cancer predisposition syndromes; however, no mutations were observed in the p53 gene, which is the major cause of Li-Fraumeni syndrome. The micromorphology observed in the altered units in which cancer cases were detected may have a role in the expression of an unidentified gene, but does not explain alone the occurrence of cancer as a primary cause in the region.</description><subject>Alteration minerals</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Calcite</subject><subject>Cancer</subject><subject>Cretaceous</subject><subject>Crystalline rocks</subject><subject>Diagenesis</subject><subject>Earth and Environmental Science</subject><subject>Earth Sciences</subject><subject>Earth, ocean, space</subject><subject>Engineering and environment geology. 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Piril</au><au>Aydin, S. Nihal</au><au>Yakicier, Cengiz</au><au>Akarsu, Nurten</au><au>Tuncer, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental effect and genetic influence: a regional cancer predisposition survey in the Zonguldak region of Northwest Turkey</atitle><jtitle>Environmental earth sciences</jtitle><stitle>Environ Geol</stitle><date>2008-03-01</date><risdate>2008</risdate><volume>54</volume><issue>2</issue><spage>391</spage><epage>409</epage><pages>391-409</pages><issn>0943-0105</issn><issn>1866-6280</issn><eissn>1432-0495</eissn><eissn>1866-6299</eissn><abstract>The Cretaceous-Eocene volcano-sedimentary units of the Zonguldak region of the western Black Sea consist of subalkaline andesite and tuff, and sandstone dominated by smectite, kaolinite, accessory chlorite, illite, mordenite, and analcime associated with feldspar, quartz, opal-CT, amphibole, and calcite. Kaolinization, chloritization, sericitization, albitization, Fe-Ti-oxidation, and the presence of zeolite, epidote, and illite in andesitic rocks and tuffaceous materials developed as a result of the degradation of a glass shards matrix, enclosed feldspar, and clinopyroxene-type phenocrysts, due to alteration processes. The association of feldspar and glass with smectite and kaolinite, and the suborientation of feldspar-edged, subparallel kaolinite plates to fracture axes may exhibit an authigenic smectite or kaolinite. Increased alteration degree upward in which Al, Fe, and Ti are gained, and Si, Na, K, and Ca are depleted, is due to the alteration following possible diagenesis and hydrothermal activities. Micromorphologically, fibrous mordenite in the altered units and the presence of needle-type chrysotile in the residential buildings in which cancer cases lived were detected. In addition, the segregation pattern of cancer susceptibility in the region strongly suggested an environmental effect and a genetic influence on the increased cancer incidence in the region. The most likely diagnosis was Li-Fraumeni syndrome, which is one of the hereditary cancer predisposition syndromes; however, no mutations were observed in the p53 gene, which is the major cause of Li-Fraumeni syndrome. The micromorphology observed in the altered units in which cancer cases were detected may have a role in the expression of an unidentified gene, but does not explain alone the occurrence of cancer as a primary cause in the region.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><doi>10.1007/s00254-007-0826-3</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Environmental earth sciences, 2008-03, Vol.54 (2), p.391-409 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Alteration minerals Analysis. Health state Biological and medical sciences Calcite Cancer Cretaceous Crystalline rocks Diagenesis Earth and Environmental Science Earth Sciences Earth, ocean, space Engineering and environment geology. Geothermics Environmental effects Environmental health Eocene Epidemiology Exact sciences and technology General aspects Genetic influence Genetics geochemistry Geology Health effects Igneous and metamorphic rocks petrology, volcanic processes, magmas Illite Kaolinite Medical sciences Mineralogy Morphology Original Article Pollution, environment geology Public health. Hygiene Public health. Hygiene-occupational medicine Residential areas Sandstone Sedimentary geology Turkey Volcanoes Volcanology Volcanosedimentary units Zonguldak |
| title | Environmental effect and genetic influence: a regional cancer predisposition survey in the Zonguldak region of Northwest Turkey |
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