Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning
The purpose of this study was to investigate the role of the ventromedial prefrontal cortex (vmPFC) in the expression of extinguished heroin seeking as measured by conditioned place preference (CPP) in males Sprague–Dawley rats ( n = 25). Heroin place conditioning (0.3 mg/kg SC × 4 sessions) was fol...
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| Veröffentlicht in: | Neuroscience letters 2008-10, Vol.444 (1), p.52-55 |
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| creator | Ovari, Jelena Leri, Francesco |
| description | The purpose of this study was to investigate the role of the ventromedial prefrontal cortex (vmPFC) in the expression of extinguished heroin seeking as measured by conditioned place preference (CPP) in males Sprague–Dawley rats (
n
=
25). Heroin place conditioning (0.3
mg/kg SC
×
4 sessions) was followed by a test of preference 24
h later, extinction (saline
×
4 sessions), heroin reconditioning (saline or 1.0
mg/kg
×
1 session), and a second test of place preference 24
h later. Fifteen minutes prior to this test, rats received intra-vmPFC infusions (bilateral, 0.5
μl/side) of a mixture of GABA
A (muscimol; 0.03
nmol) and a GABA
B (baclofen; 0.3
nmol) agonists, or vehicle. As expected on the basis of previous studies, reconditioning with heroin resulted in the re-emergence of a CPP. Importantly, inactivation of the vmPFC produced the same effect in animals that did not receive heroin on the session of reconditioning. These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking. |
| doi_str_mv | 10.1016/j.neulet.2008.08.015 |
| format | Article |
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n
=
25). Heroin place conditioning (0.3
mg/kg SC
×
4 sessions) was followed by a test of preference 24
h later, extinction (saline
×
4 sessions), heroin reconditioning (saline or 1.0
mg/kg
×
1 session), and a second test of place preference 24
h later. Fifteen minutes prior to this test, rats received intra-vmPFC infusions (bilateral, 0.5
μl/side) of a mixture of GABA
A (muscimol; 0.03
nmol) and a GABA
B (baclofen; 0.3
nmol) agonists, or vehicle. As expected on the basis of previous studies, reconditioning with heroin resulted in the re-emergence of a CPP. Importantly, inactivation of the vmPFC produced the same effect in animals that did not receive heroin on the session of reconditioning. These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2008.08.015</identifier><identifier>PMID: 18706971</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Analysis of Variance ; Animals ; Baclofen - pharmacology ; Behavior, Animal - drug effects ; Biological and medical sciences ; Conditioning, Operant - drug effects ; Conditioning, Operant - physiology ; Extinction ; Extinction, Psychological - drug effects ; Fundamental and applied biological sciences. Psychology ; GABA agonists ; GABA Agonists - pharmacology ; GABA Antagonists - pharmacology ; Heroin ; Heroin - administration & dosage ; Heroin Dependence - psychology ; Inhibition (Psychology) ; Male ; Muscimol - pharmacology ; Narcotics - administration & dosage ; Place conditioning ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiology ; Rats ; Rats, Sprague-Dawley ; Reacquisition ; Reconditioning ; Ventromedial prefrontal cortex ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2008-10, Vol.444 (1), p.52-55</ispartof><rights>2008 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-57c165495951a4feda8d0ef6ad31d411d2ad25f2d98b9c6c1090afdf563513a83</citedby><cites>FETCH-LOGICAL-c487t-57c165495951a4feda8d0ef6ad31d411d2ad25f2d98b9c6c1090afdf563513a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394008011178$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20662608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18706971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ovari, Jelena</creatorcontrib><creatorcontrib>Leri, Francesco</creatorcontrib><title>Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>The purpose of this study was to investigate the role of the ventromedial prefrontal cortex (vmPFC) in the expression of extinguished heroin seeking as measured by conditioned place preference (CPP) in males Sprague–Dawley rats (
n
=
25). Heroin place conditioning (0.3
mg/kg SC
×
4 sessions) was followed by a test of preference 24
h later, extinction (saline
×
4 sessions), heroin reconditioning (saline or 1.0
mg/kg
×
1 session), and a second test of place preference 24
h later. Fifteen minutes prior to this test, rats received intra-vmPFC infusions (bilateral, 0.5
μl/side) of a mixture of GABA
A (muscimol; 0.03
nmol) and a GABA
B (baclofen; 0.3
nmol) agonists, or vehicle. As expected on the basis of previous studies, reconditioning with heroin resulted in the re-emergence of a CPP. Importantly, inactivation of the vmPFC produced the same effect in animals that did not receive heroin on the session of reconditioning. These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Baclofen - pharmacology</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Conditioning, Operant - drug effects</subject><subject>Conditioning, Operant - physiology</subject><subject>Extinction</subject><subject>Extinction, Psychological - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA agonists</subject><subject>GABA Agonists - pharmacology</subject><subject>GABA Antagonists - pharmacology</subject><subject>Heroin</subject><subject>Heroin - administration & dosage</subject><subject>Heroin Dependence - psychology</subject><subject>Inhibition (Psychology)</subject><subject>Male</subject><subject>Muscimol - pharmacology</subject><subject>Narcotics - administration & dosage</subject><subject>Place conditioning</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reacquisition</subject><subject>Reconditioning</subject><subject>Ventromedial prefrontal cortex</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQhoMo7uzqG4jkorceK-kk3X0RZFF3YcGLnkMmqd7N2J2MSXrYfXvTzKg3oSCB-v5K5SPkDYMtA6Y-7LcBlwnLlgP027WYfEY2rO940w0df0420IJo2kHABbnMeQ8AkknxklxUCNTQsQ15vA3GFn80xcdA40jLA9IjhpLijM6biR4SjimGUq82poKPdPazt5kmbHDGdI_B4pp8wBR9oBnxpw_31Jolo6O7pz-NhDYG59eHav8VeTGaKePr83lFfnz5_P36prn79vX2-tNdY0XflUZ2likpBjlIZsSIzvQOcFTGtcwJxhw3jsuRu6HfDVZZBgOY0Y1StZK1pm-vyPvT3EOKvxbMRc8-W5wmEzAuWXMGgveCVVCcQJtizvXT-pD8bNKTZqBX43qvT8b1alyvxWSNvT3PX3bV2L_QWXEF3p0Bk62ZxmSC9fkvx0EprmBd9OOJw2rj6DHpbP3q1vlqrmgX_f83-Q1HzKPQ</recordid><startdate>20081017</startdate><enddate>20081017</enddate><creator>Ovari, Jelena</creator><creator>Leri, Francesco</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20081017</creationdate><title>Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning</title><author>Ovari, Jelena ; Leri, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-57c165495951a4feda8d0ef6ad31d411d2ad25f2d98b9c6c1090afdf563513a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Baclofen - pharmacology</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Conditioning, Operant - drug effects</topic><topic>Conditioning, Operant - physiology</topic><topic>Extinction</topic><topic>Extinction, Psychological - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA agonists</topic><topic>GABA Agonists - pharmacology</topic><topic>GABA Antagonists - pharmacology</topic><topic>Heroin</topic><topic>Heroin - administration & dosage</topic><topic>Heroin Dependence - psychology</topic><topic>Inhibition (Psychology)</topic><topic>Male</topic><topic>Muscimol - pharmacology</topic><topic>Narcotics - administration & dosage</topic><topic>Place conditioning</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reacquisition</topic><topic>Reconditioning</topic><topic>Ventromedial prefrontal cortex</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ovari, Jelena</creatorcontrib><creatorcontrib>Leri, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ovari, Jelena</au><au>Leri, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2008-10-17</date><risdate>2008</risdate><volume>444</volume><issue>1</issue><spage>52</spage><epage>55</epage><pages>52-55</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>The purpose of this study was to investigate the role of the ventromedial prefrontal cortex (vmPFC) in the expression of extinguished heroin seeking as measured by conditioned place preference (CPP) in males Sprague–Dawley rats (
n
=
25). Heroin place conditioning (0.3
mg/kg SC
×
4 sessions) was followed by a test of preference 24
h later, extinction (saline
×
4 sessions), heroin reconditioning (saline or 1.0
mg/kg
×
1 session), and a second test of place preference 24
h later. Fifteen minutes prior to this test, rats received intra-vmPFC infusions (bilateral, 0.5
μl/side) of a mixture of GABA
A (muscimol; 0.03
nmol) and a GABA
B (baclofen; 0.3
nmol) agonists, or vehicle. As expected on the basis of previous studies, reconditioning with heroin resulted in the re-emergence of a CPP. Importantly, inactivation of the vmPFC produced the same effect in animals that did not receive heroin on the session of reconditioning. These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18706971</pmid><doi>10.1016/j.neulet.2008.08.015</doi><tpages>4</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Baclofen - pharmacology Behavior, Animal - drug effects Biological and medical sciences Conditioning, Operant - drug effects Conditioning, Operant - physiology Extinction Extinction, Psychological - drug effects Fundamental and applied biological sciences. Psychology GABA agonists GABA Agonists - pharmacology GABA Antagonists - pharmacology Heroin Heroin - administration & dosage Heroin Dependence - psychology Inhibition (Psychology) Male Muscimol - pharmacology Narcotics - administration & dosage Place conditioning Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Rats Rats, Sprague-Dawley Reacquisition Reconditioning Ventromedial prefrontal cortex Vertebrates: nervous system and sense organs |
| title | Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning |
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