The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol

Introduction: Drug-induced long QT syndrome (LQTS) has been linked to arrhythmias (including Torsades de Pointes and sudden cardiac death), and has led to an increased awareness of the potential risk of delayed repolarization in vitro and in vivo. However, in vitro assessments of delayed repolarizat...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2007-07, Vol.56 (1), p.11-17
Hauptverfasser:	Limberis, James T., McDermott, Jeff S., Salmen, Heinz J., Su, Zhi, Mikhail, Ann, Green, Jonathon R., Cox, Bryan F., Gintant, Gary A., Martin, Ruth L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Action Potentials - drug effects Animals Blood Proteins - metabolism Canine Purkinje fiber Cardiac repolarization Cisapride - adverse effects Cisapride - metabolism Dogs Humans In Vitro Techniques Isotonic Solutions Methods Models, Biological Plasma protein binding Protein Binding Purkinje Fibers - drug effects Purkinje Fibers - physiology Q–T prolongation Risperidone - adverse effects Risperidone - metabolism Serum Albumin - metabolism Serum Albumin - pharmacology Sotalol - adverse effects Sotalol - metabolism
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