Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses

Immunotherapy with checkpoint inhibitors has proved to be highly effective, with durable responses in a subset of patients. Given their encouraging clinical activity, checkpoint inhibitors are increasingly being tested in clinical trials in combination with chemotherapy. In many instances, there is...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-10, Vol.201 (8), p.2273-2286
Hauptverfasser:	Cubas, Rafael, Moskalenko, Marina, Cheung, Jeanne, Yang, Michelle, McNamara, Erin, Xiong, Huizhong, Hoves, Sabine, Ries, Carola H, Kim, Jeong, Gould, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - therapy Animals Antibodies, Monoclonal - therapeutic use Antigens, Neoplasm - immunology Antineoplastic Combined Chemotherapy Protocols - therapeutic use B7-H1 Antigen - immunology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Colonic Neoplasms - immunology Colonic Neoplasms - therapy Female Flow Cytometry Humans Immunity, Cellular Immunotherapy - methods Mice Mice, Inbred C57BL Neoplasms, Experimental Tumor Burden - drug effects
Online-Zugang:	Volltext
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