Ferula hermonis impairs sexual behavior in hormone-primed female rats
The influence of Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with F. hermonis extract acutely...
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| Veröffentlicht in: | Physiology & behavior 2005-09, Vol.86 (1), p.69-74 |
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| creator | Zanoli, Paola Zavatti, Manuela Rivasi, Marianna Baraldi, Mario |
| description | The influence of
Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with
F. hermonis extract acutely (30 and 60 mg/kg) or subchronically (1 and 10 mg/kg daily for 10 consecutive days).
A significant reduction in lordosis responses was observed in rats after acute (60 mg/kg) or subchronic (1 and 10 mg/kg) administration of the plant extract. Similarly, a decrease in proceptive behaviors was exhibited by
F. hermonis treated rats in comparison with EB
+
P controls. No difference was found in the patterns of paced mating behavior between control and treated animals.
The present results demonstrate that the acute or repeated ingestion of
F. hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats. |
| doi_str_mv | 10.1016/j.physbeh.2005.06.025 |
| format | Article |
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Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with
F. hermonis extract acutely (30 and 60 mg/kg) or subchronically (1 and 10 mg/kg daily for 10 consecutive days).
A significant reduction in lordosis responses was observed in rats after acute (60 mg/kg) or subchronic (1 and 10 mg/kg) administration of the plant extract. Similarly, a decrease in proceptive behaviors was exhibited by
F. hermonis treated rats in comparison with EB
+
P controls. No difference was found in the patterns of paced mating behavior between control and treated animals.
The present results demonstrate that the acute or repeated ingestion of
F. hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2005.06.025</identifier><identifier>PMID: 16084537</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Analysis of Variance ; Animal ethology ; Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Combinations ; Drug Interactions ; Estradiol - pharmacology ; Female ; Ferula - chemistry ; Ferula hermonis ; Fundamental and applied biological sciences. Psychology ; Mammalia ; Ovariectomy - methods ; Paced mating behavior ; Phytoestrogen ; Plant Extracts - administration & dosage ; Plant Extracts - adverse effects ; Posture - physiology ; Proceptivity ; Progesterone - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Rat ; Rats ; Sexual Behavior, Animal - drug effects ; Sexual receptivity ; Vertebrata</subject><ispartof>Physiology & behavior, 2005-09, Vol.86 (1), p.69-74</ispartof><rights>2005 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-dbba5b5dcc3cbfabcad44f55e4450824064cb9c19e8358ef245171e9f7b210a43</citedby><cites>FETCH-LOGICAL-c424t-dbba5b5dcc3cbfabcad44f55e4450824064cb9c19e8358ef245171e9f7b210a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0031938405002556$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17137238$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16084537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zanoli, Paola</creatorcontrib><creatorcontrib>Zavatti, Manuela</creatorcontrib><creatorcontrib>Rivasi, Marianna</creatorcontrib><creatorcontrib>Baraldi, Mario</creatorcontrib><title>Ferula hermonis impairs sexual behavior in hormone-primed female rats</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>The influence of
Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with
F. hermonis extract acutely (30 and 60 mg/kg) or subchronically (1 and 10 mg/kg daily for 10 consecutive days).
A significant reduction in lordosis responses was observed in rats after acute (60 mg/kg) or subchronic (1 and 10 mg/kg) administration of the plant extract. Similarly, a decrease in proceptive behaviors was exhibited by
F. hermonis treated rats in comparison with EB
+
P controls. No difference was found in the patterns of paced mating behavior between control and treated animals.
The present results demonstrate that the acute or repeated ingestion of
F. hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats.</description><subject>Analysis of Variance</subject><subject>Animal ethology</subject><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug Combinations</subject><subject>Drug Interactions</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Ferula - chemistry</subject><subject>Ferula hermonis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mammalia</subject><subject>Ovariectomy - methods</subject><subject>Paced mating behavior</subject><subject>Phytoestrogen</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - adverse effects</subject><subject>Posture - physiology</subject><subject>Proceptivity</subject><subject>Progesterone - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Rat</subject><subject>Rats</subject><subject>Sexual Behavior, Animal - drug effects</subject><subject>Sexual receptivity</subject><subject>Vertebrata</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMozjj6CEo3umtNmqSXlcgwo8KAGwV3IUlPaYbeTFpx3t6UKczSszmb7z-XD6FbgiOCSfK4j_rq4BRUUYwxj3AS4ZifoSXJUhpynH6doyXGlIQ5zdgCXTm3x74oo5doQRKcMU7TJdpswY61DCqwTdcaF5iml8a6wMHvKOvAL5A_prOBaYOqmxgIe2saKIISGllDYOXgrtFFKWsHN3Nfoc_t5mP9Gu7eX97Wz7tQs5gNYaGU5IoXWlOtSqm0LBgrOQfGOM5ihhOmVa5JDhnlGZQx4yQlkJepigmWjK7Qw3Fub7vvEdwgGuM01LVsoRud8BRlLEs8yI-gtp1zFkoxHS3tQRAsJn9iL2Z_YvIncCK8P5-7mxeMyv94Ss3CPHA_A9JpWZdWttq4E5cSmsY089zTkQOv48eAFU4baDUUxoIeRNGZf075A5r2kdo</recordid><startdate>20050915</startdate><enddate>20050915</enddate><creator>Zanoli, Paola</creator><creator>Zavatti, Manuela</creator><creator>Rivasi, Marianna</creator><creator>Baraldi, Mario</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20050915</creationdate><title>Ferula hermonis impairs sexual behavior in hormone-primed female rats</title><author>Zanoli, Paola ; Zavatti, Manuela ; Rivasi, Marianna ; Baraldi, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-dbba5b5dcc3cbfabcad44f55e4450824064cb9c19e8358ef245171e9f7b210a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animal ethology</topic><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug Combinations</topic><topic>Drug Interactions</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Ferula - chemistry</topic><topic>Ferula hermonis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mammalia</topic><topic>Ovariectomy - methods</topic><topic>Paced mating behavior</topic><topic>Phytoestrogen</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - adverse effects</topic><topic>Posture - physiology</topic><topic>Proceptivity</topic><topic>Progesterone - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Rat</topic><topic>Rats</topic><topic>Sexual Behavior, Animal - drug effects</topic><topic>Sexual receptivity</topic><topic>Vertebrata</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zanoli, Paola</creatorcontrib><creatorcontrib>Zavatti, Manuela</creatorcontrib><creatorcontrib>Rivasi, Marianna</creatorcontrib><creatorcontrib>Baraldi, Mario</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zanoli, Paola</au><au>Zavatti, Manuela</au><au>Rivasi, Marianna</au><au>Baraldi, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ferula hermonis impairs sexual behavior in hormone-primed female rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2005-09-15</date><risdate>2005</risdate><volume>86</volume><issue>1</issue><spage>69</spage><epage>74</epage><pages>69-74</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>The influence of
Ferula hermonis root extract on sexual behavior was studied in female rats. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate (EB) and progesterone (P) and then treated with
F. hermonis extract acutely (30 and 60 mg/kg) or subchronically (1 and 10 mg/kg daily for 10 consecutive days).
A significant reduction in lordosis responses was observed in rats after acute (60 mg/kg) or subchronic (1 and 10 mg/kg) administration of the plant extract. Similarly, a decrease in proceptive behaviors was exhibited by
F. hermonis treated rats in comparison with EB
+
P controls. No difference was found in the patterns of paced mating behavior between control and treated animals.
The present results demonstrate that the acute or repeated ingestion of
F. hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16084537</pmid><doi>10.1016/j.physbeh.2005.06.025</doi><tpages>6</tpages></addata></record> |
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| subjects | Analysis of Variance Animal ethology Animals Behavior, Animal - drug effects Biological and medical sciences Dose-Response Relationship, Drug Drug Administration Schedule Drug Combinations Drug Interactions Estradiol - pharmacology Female Ferula - chemistry Ferula hermonis Fundamental and applied biological sciences. Psychology Mammalia Ovariectomy - methods Paced mating behavior Phytoestrogen Plant Extracts - administration & dosage Plant Extracts - adverse effects Posture - physiology Proceptivity Progesterone - pharmacology Psychology. Psychoanalysis. Psychiatry Rat Rats Sexual Behavior, Animal - drug effects Sexual receptivity Vertebrata |
| title | Ferula hermonis impairs sexual behavior in hormone-primed female rats |
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