Oncostatin M induces functional and structural impairment of blood–brain barriers comprised of rat brain capillary endothelial cells
Oncostatin M (OSM), a member of the interleukin-6 family, is produced by monocytes and macrophages in the peripheral blood and microglia in the brain. The present study aimed to elucidate a regulatory role of OSM in the functions of blood–brain barrier (BBB) comprised of rat brain capillary endothel...
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| Veröffentlicht in: | Neuroscience letters 2008-08, Vol.441 (2), p.163-166 |
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| container_title | Neuroscience letters |
| container_volume | 441 |
| creator | Takata, Fuyuko Sumi, Noriko Nishioku, Tsuyoshi Harada, Eriko Wakigawa, Tomoya Shuto, Hideki Yamauchi, Atsushi Kataoka, Yasufumi |
| description | Oncostatin M (OSM), a member of the interleukin-6 family, is produced by monocytes and macrophages in the peripheral blood and microglia in the brain. The present study aimed to elucidate a regulatory role of OSM in the functions of blood–brain barrier (BBB) comprised of rat brain capillary endothelial cells (RBECs). OSM decreased the transendothelial electrical resistance of RBEC monolayers in a concentration- and time-dependent manner. Immunocytochemical observations of ZO-1 and claudin-5 in OSM-treated RBECs showed a zipper-like and/or zigzag shape along the junctions between cells, in contrast with the smooth and linear shape in vehicle-treated cultures. When RBECs were pre-treated with anti-OSM antibody, OSM failed to evoke these changes. The cellular constituents producing OSM in the brain and peripheral blood could be implicated in the functional and structural impairment of the BBB. |
| doi_str_mv | 10.1016/j.neulet.2008.06.030 |
| format | Article |
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The present study aimed to elucidate a regulatory role of OSM in the functions of blood–brain barrier (BBB) comprised of rat brain capillary endothelial cells (RBECs). OSM decreased the transendothelial electrical resistance of RBEC monolayers in a concentration- and time-dependent manner. Immunocytochemical observations of ZO-1 and claudin-5 in OSM-treated RBECs showed a zipper-like and/or zigzag shape along the junctions between cells, in contrast with the smooth and linear shape in vehicle-treated cultures. When RBECs were pre-treated with anti-OSM antibody, OSM failed to evoke these changes. The cellular constituents producing OSM in the brain and peripheral blood could be implicated in the functional and structural impairment of the BBB.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2008.06.030</identifier><identifier>PMID: 18603369</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antibodies - pharmacology ; Biological and medical sciences ; Blood-Brain Barrier - cytology ; Blood–brain barrier ; Cells, Cultured ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Claudin-5 ; Dose-Response Relationship, Drug ; Electric Impedance ; Endothelial Cells - drug effects ; Endothelial Cells - pathology ; Fundamental and applied biological sciences. Psychology ; Growth Inhibitors - immunology ; Growth Inhibitors - toxicity ; Membrane Proteins - metabolism ; Mice ; Oncostatin M ; Oncostatin M - immunology ; Oncostatin M - toxicity ; Rat brain endothelial cell ; Rats ; Rats, Wistar ; Tight junction ; Time Factors ; Vertebrates: nervous system and sense organs ; ZO-1</subject><ispartof>Neuroscience letters, 2008-08, Vol.441 (2), p.163-166</ispartof><rights>2008 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-ec9fac6b064b746af98382e4aa4d4e4ea41f8c0a8f205d87a66131f83f3c604b3</citedby><cites>FETCH-LOGICAL-c487t-ec9fac6b064b746af98382e4aa4d4e4ea41f8c0a8f205d87a66131f83f3c604b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2008.06.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20525957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18603369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takata, Fuyuko</creatorcontrib><creatorcontrib>Sumi, Noriko</creatorcontrib><creatorcontrib>Nishioku, Tsuyoshi</creatorcontrib><creatorcontrib>Harada, Eriko</creatorcontrib><creatorcontrib>Wakigawa, Tomoya</creatorcontrib><creatorcontrib>Shuto, Hideki</creatorcontrib><creatorcontrib>Yamauchi, Atsushi</creatorcontrib><creatorcontrib>Kataoka, Yasufumi</creatorcontrib><title>Oncostatin M induces functional and structural impairment of blood–brain barriers comprised of rat brain capillary endothelial cells</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Oncostatin M (OSM), a member of the interleukin-6 family, is produced by monocytes and macrophages in the peripheral blood and microglia in the brain. The present study aimed to elucidate a regulatory role of OSM in the functions of blood–brain barrier (BBB) comprised of rat brain capillary endothelial cells (RBECs). OSM decreased the transendothelial electrical resistance of RBEC monolayers in a concentration- and time-dependent manner. Immunocytochemical observations of ZO-1 and claudin-5 in OSM-treated RBECs showed a zipper-like and/or zigzag shape along the junctions between cells, in contrast with the smooth and linear shape in vehicle-treated cultures. When RBECs were pre-treated with anti-OSM antibody, OSM failed to evoke these changes. The cellular constituents producing OSM in the brain and peripheral blood could be implicated in the functional and structural impairment of the BBB.</description><subject>Animals</subject><subject>Antibodies - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - cytology</subject><subject>Blood–brain barrier</subject><subject>Cells, Cultured</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Claudin-5</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electric Impedance</subject><subject>Endothelial Cells - drug effects</subject><subject>Endothelial Cells - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Inhibitors - immunology</subject><subject>Growth Inhibitors - toxicity</subject><subject>Membrane Proteins - metabolism</subject><subject>Mice</subject><subject>Oncostatin M</subject><subject>Oncostatin M - immunology</subject><subject>Oncostatin M - toxicity</subject><subject>Rat brain endothelial cell</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tight junction</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>ZO-1</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2u1SAURonReI9X38AYJjprhZbSdmJibvxLrrkTHZNd2EROKByBmjhz5Av4hj6JnPREZ44Im_XtfCxCnnLWcsbly2MbcPNY2o6xqWWyZT27Rw58GrtmnMfuPjnUiWj6WbAr8ijnI2Ns4IN4SK74JFnfy_lAft4FHXOB4gL9SF0wm8ZM7RZ0cTGApxAMzSVtumypXt16ApdWDIVGSxcfo_n949eSoOYXSMlhylTH9ZRcRnNmEhS6v2s4Oe8hfacYTCxf0Lu6UaP3-TF5YMFnfHI5r8nnt28-3bxvbu_efbh5fdtoMY2lQT1b0HJhUiyjkGDnqZ86FADCCBQIgttJM5hsxwYzjSAl7-uot72WTCz9NXmx7z2l-HXDXNTq8rkBBIxbVh1n3TwKXkGxgzrFnBNaVX-01u6KM3X2r45q96_O_hWTqtqusWeX_duyovkXugivwPMLAFmDtwmCdvkvV2t3wzyMlXu1c1htfKtWVdYOg0bjEuqiTHT_b_IHaBOqIg</recordid><startdate>20080822</startdate><enddate>20080822</enddate><creator>Takata, Fuyuko</creator><creator>Sumi, Noriko</creator><creator>Nishioku, Tsuyoshi</creator><creator>Harada, Eriko</creator><creator>Wakigawa, Tomoya</creator><creator>Shuto, Hideki</creator><creator>Yamauchi, Atsushi</creator><creator>Kataoka, Yasufumi</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>20080822</creationdate><title>Oncostatin M induces functional and structural impairment of blood–brain barriers comprised of rat brain capillary endothelial cells</title><author>Takata, Fuyuko ; Sumi, Noriko ; Nishioku, Tsuyoshi ; Harada, Eriko ; Wakigawa, Tomoya ; Shuto, Hideki ; Yamauchi, Atsushi ; Kataoka, Yasufumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-ec9fac6b064b746af98382e4aa4d4e4ea41f8c0a8f205d87a66131f83f3c604b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Antibodies - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - cytology</topic><topic>Blood–brain barrier</topic><topic>Cells, Cultured</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Claudin-5</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electric Impedance</topic><topic>Endothelial Cells - drug effects</topic><topic>Endothelial Cells - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Inhibitors - immunology</topic><topic>Growth Inhibitors - toxicity</topic><topic>Membrane Proteins - metabolism</topic><topic>Mice</topic><topic>Oncostatin M</topic><topic>Oncostatin M - immunology</topic><topic>Oncostatin M - toxicity</topic><topic>Rat brain endothelial cell</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tight junction</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>ZO-1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takata, Fuyuko</creatorcontrib><creatorcontrib>Sumi, Noriko</creatorcontrib><creatorcontrib>Nishioku, Tsuyoshi</creatorcontrib><creatorcontrib>Harada, Eriko</creatorcontrib><creatorcontrib>Wakigawa, Tomoya</creatorcontrib><creatorcontrib>Shuto, Hideki</creatorcontrib><creatorcontrib>Yamauchi, Atsushi</creatorcontrib><creatorcontrib>Kataoka, Yasufumi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takata, Fuyuko</au><au>Sumi, Noriko</au><au>Nishioku, Tsuyoshi</au><au>Harada, Eriko</au><au>Wakigawa, Tomoya</au><au>Shuto, Hideki</au><au>Yamauchi, Atsushi</au><au>Kataoka, Yasufumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oncostatin M induces functional and structural impairment of blood–brain barriers comprised of rat brain capillary endothelial cells</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2008-08-22</date><risdate>2008</risdate><volume>441</volume><issue>2</issue><spage>163</spage><epage>166</epage><pages>163-166</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Oncostatin M (OSM), a member of the interleukin-6 family, is produced by monocytes and macrophages in the peripheral blood and microglia in the brain. The present study aimed to elucidate a regulatory role of OSM in the functions of blood–brain barrier (BBB) comprised of rat brain capillary endothelial cells (RBECs). OSM decreased the transendothelial electrical resistance of RBEC monolayers in a concentration- and time-dependent manner. Immunocytochemical observations of ZO-1 and claudin-5 in OSM-treated RBECs showed a zipper-like and/or zigzag shape along the junctions between cells, in contrast with the smooth and linear shape in vehicle-treated cultures. When RBECs were pre-treated with anti-OSM antibody, OSM failed to evoke these changes. The cellular constituents producing OSM in the brain and peripheral blood could be implicated in the functional and structural impairment of the BBB.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>18603369</pmid><doi>10.1016/j.neulet.2008.06.030</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2008-08, Vol.441 (2), p.163-166 |
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| subjects | Animals Antibodies - pharmacology Biological and medical sciences Blood-Brain Barrier - cytology Blood–brain barrier Cells, Cultured Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Claudin-5 Dose-Response Relationship, Drug Electric Impedance Endothelial Cells - drug effects Endothelial Cells - pathology Fundamental and applied biological sciences. Psychology Growth Inhibitors - immunology Growth Inhibitors - toxicity Membrane Proteins - metabolism Mice Oncostatin M Oncostatin M - immunology Oncostatin M - toxicity Rat brain endothelial cell Rats Rats, Wistar Tight junction Time Factors Vertebrates: nervous system and sense organs ZO-1 |
| title | Oncostatin M induces functional and structural impairment of blood–brain barriers comprised of rat brain capillary endothelial cells |
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