Development and evaluation of lipid nanoparticles for camptothecin delivery： a comparison of solid lipid nanoparticles, nanostructured lipid carriers, and lipid emulsion

Aim： Camptothecin is an anticancer drug that acts against a broad spectrum of tumors. The clinical application of camptothecin is limited by its insolubility, instability, and toxicity problems. The aim of this study was to develop and characterize lipid nanoparticles with different lipid cores whic...

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Veröffentlicht in:	Acta pharmacologica Sinica 2008-09, Vol.29 (9), p.1094-1102
Hauptverfasser:	Huang, Zih-rou, Hua, Shu-chiou, Yang, Yueh-lung, Fang, Jia-you
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - pharmacology Biomedical and Life Sciences Biomedicine camptothecin Camptothecin - administration & dosage Camptothecin - pharmacology Cell Line, Tumor Chemistry, Pharmaceutical Drug Carriers - chemistry drug delivery Drug Delivery Systems Drug Stability Emulsions Erythrocytes - drug effects Excipients Hemolysis - drug effects Humans Immunology In Vitro Techniques Injections Internal Medicine lipid emulsion Lipids - chemistry Medical Microbiology melanoma Nanoparticles nanostructured lipid carrier original-article Particle Size Pharmacology/Toxicology solid lipid nanoparticle Vaccine 喜树碱固体脂质纳米颗粒纳米结构脂质乳剂
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