Zeolite X from coal fly ash inhibits proliferation of human breast cancer cell lines (MCF-7) via induction of S phase arrest and apoptosis

In this study, zeolite X synthesised from coal fly ash (CFA) was examined for its anti-proliferative effects on human breast cancer MCF-7 cells by in vitro studies and allied probable molecular mechanism were also assessed. MTT assay exposed that zeolite X showed a concentration-dependent inhibitory...

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Veröffentlicht in:	Molecular biology reports 2018-12, Vol.45 (6), p.2063-2074
Hauptverfasser:	Subhapriya, S., Gomathipriya, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry Annexin V Apoptosis Apoptosis - drug effects Bcl-2 protein bcl-2-Associated X Protein Biomedical and Life Sciences Breast cancer Breast Neoplasms - metabolism Caspase Caspase 3 Cell Cycle Checkpoints - drug effects Cell death Cell proliferation Cell Proliferation - drug effects Cell Survival Coal Ash - pharmacology Confocal microscopy Cytochrome c Cytochromes c Cytosol Cytotoxicity Deoxyribonucleic acid DNA Female Flow cytometry Fly ash Histology Humans Life Sciences MCF-7 Cells - drug effects Membrane Potential, Mitochondrial Mitochondria Morphology Original Article Propidium iodide Proto-Oncogene Proteins c-bcl-2 S phase S Phase - drug effects Tumor cell lines Zeolites Zeolites - pharmacology
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