HTLV-1: A real pathogen or a runaway guest of a diseased cell?
The human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus claimed to be aetiologically linked to the adult T-cell leukaemia/lymphoma (ATLL) and associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other minor pathologies. HTLV-1 infection is worldwide distributed, desp...
Gespeichert in:
| Veröffentlicht in: | Journal of biosciences 2018-09, Vol.43 (4), p.785-795 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 795 |
|---|---|
| container_issue | 4 |
| container_start_page | 785 |
| container_title | Journal of biosciences |
| container_volume | 43 |
| creator | Kanzaki, L I B |
| description | The human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus claimed to be aetiologically linked to the adult T-cell leukaemia/lymphoma (ATLL) and associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other minor pathologies. HTLV-1 infection is worldwide distributed, despite its heterogeneous prevalence. Environmental factors and host-genetic background are very likely to determine the epidemiological profile of HTLV-1 prevalence and related disease confinement in distinct human ethnic populations and geographical coordinates, which raises the question if the virus is a real pathogen or a runaway well-organized packed genome of a burden host cell near death process. New methodological approaches need to be proposed and applied in order to prove or discard the hypotheses emerged in the present review. |
| doi_str_mv | 10.1007/s12038-018-9787-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2102922773</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2102922773</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-80fe8a0dff5555436e149a5d69f813064566d125e0d47d33774bdd7ab37d10583</originalsourceid><addsrcrecordid>eNp1kEFLwzAYhoMobk5_gBcJePES_ZK0TeJBGUOdMPAyvYZsSeZG185kRfbvTelUEMwlIXm-Ny8PQucUrimAuImUAZcEqCRKSEHUAeqDEpwIyuVhOrMcSK4U7aGTGFcAVGUcjlGPAwPBGeuju_F08kboLR7i4EyJN2b7Xi9cheuADQ5NZT7NDi8aF7e49unKLqMz0Vk8d2V5f4qOvCmjO9vvA_T6-DAdjcnk5el5NJyQORdsSyR4Jw1Y7_O0Ml44mimT20J5STkUWV4UlrLcgc2E5VyIbGatMDMuLIVc8gG66nI3of5oy-j1MrYNTOXqJmpGgSnGhOAJvfyDruomVKmdZiCZVCmupWhHzUMdY3Beb8JybcJOU9CtXN3J1UmubuVqlWYu9snNbO3sz8S3zQSwDojpqVq48Pv1_6lfpBmAKw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2082895833</pqid></control><display><type>article</type><title>HTLV-1: A real pathogen or a runaway guest of a diseased cell?</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SpringerNature Journals</source><source>Indian Academy of Sciences</source><creator>Kanzaki, L I B</creator><creatorcontrib>Kanzaki, L I B</creatorcontrib><description>The human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus claimed to be aetiologically linked to the adult T-cell leukaemia/lymphoma (ATLL) and associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other minor pathologies. HTLV-1 infection is worldwide distributed, despite its heterogeneous prevalence. Environmental factors and host-genetic background are very likely to determine the epidemiological profile of HTLV-1 prevalence and related disease confinement in distinct human ethnic populations and geographical coordinates, which raises the question if the virus is a real pathogen or a runaway well-organized packed genome of a burden host cell near death process. New methodological approaches need to be proposed and applied in order to prove or discard the hypotheses emerged in the present review.</description><identifier>ISSN: 0250-5991</identifier><identifier>EISSN: 0973-7138</identifier><identifier>DOI: 10.1007/s12038-018-9787-9</identifier><identifier>PMID: 30207322</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell death ; Central nervous system diseases ; Environmental factors ; Epidemiology ; Genomes ; Geographical coordinates ; Hereditary spastic paraplegia ; HTLV-I Infections - epidemiology ; HTLV-I Infections - genetics ; HTLV-I Infections - virology ; Human T-lymphotropic virus 1 - genetics ; Human T-lymphotropic virus 1 - pathogenicity ; Human T-lymphotropic virus 1 - radiation effects ; Humans ; Leukemia ; Leukemia-Lymphoma, Adult T-Cell - epidemiology ; Leukemia-Lymphoma, Adult T-Cell - genetics ; Leukemia-Lymphoma, Adult T-Cell - virology ; Life Sciences ; Lymphocytes T ; Lymphoma ; Microbiology ; Minority & ethnic groups ; Paraparesis, Tropical Spastic - epidemiology ; Paraparesis, Tropical Spastic - genetics ; Paraparesis, Tropical Spastic - virology ; Pathogens ; Plant Sciences ; Radiation, Ionizing ; Review ; Spinal cord ; Tropical climate ; Tropical spastic paraparesis ; Viruses ; Zoology</subject><ispartof>Journal of biosciences, 2018-09, Vol.43 (4), p.785-795</ispartof><rights>Indian Academy of Sciences 2018</rights><rights>Journal of Biosciences is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-80fe8a0dff5555436e149a5d69f813064566d125e0d47d33774bdd7ab37d10583</citedby><cites>FETCH-LOGICAL-c372t-80fe8a0dff5555436e149a5d69f813064566d125e0d47d33774bdd7ab37d10583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12038-018-9787-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12038-018-9787-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30207322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanzaki, L I B</creatorcontrib><title>HTLV-1: A real pathogen or a runaway guest of a diseased cell?</title><title>Journal of biosciences</title><addtitle>J Biosci</addtitle><addtitle>J Biosci</addtitle><description>The human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus claimed to be aetiologically linked to the adult T-cell leukaemia/lymphoma (ATLL) and associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other minor pathologies. HTLV-1 infection is worldwide distributed, despite its heterogeneous prevalence. Environmental factors and host-genetic background are very likely to determine the epidemiological profile of HTLV-1 prevalence and related disease confinement in distinct human ethnic populations and geographical coordinates, which raises the question if the virus is a real pathogen or a runaway well-organized packed genome of a burden host cell near death process. New methodological approaches need to be proposed and applied in order to prove or discard the hypotheses emerged in the present review.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Central nervous system diseases</subject><subject>Environmental factors</subject><subject>Epidemiology</subject><subject>Genomes</subject><subject>Geographical coordinates</subject><subject>Hereditary spastic paraplegia</subject><subject>HTLV-I Infections - epidemiology</subject><subject>HTLV-I Infections - genetics</subject><subject>HTLV-I Infections - virology</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Human T-lymphotropic virus 1 - pathogenicity</subject><subject>Human T-lymphotropic virus 1 - radiation effects</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia-Lymphoma, Adult T-Cell - epidemiology</subject><subject>Leukemia-Lymphoma, Adult T-Cell - genetics</subject><subject>Leukemia-Lymphoma, Adult T-Cell - virology</subject><subject>Life Sciences</subject><subject>Lymphocytes T</subject><subject>Lymphoma</subject><subject>Microbiology</subject><subject>Minority & ethnic groups</subject><subject>Paraparesis, Tropical Spastic - epidemiology</subject><subject>Paraparesis, Tropical Spastic - genetics</subject><subject>Paraparesis, Tropical Spastic - virology</subject><subject>Pathogens</subject><subject>Plant Sciences</subject><subject>Radiation, Ionizing</subject><subject>Review</subject><subject>Spinal cord</subject><subject>Tropical climate</subject><subject>Tropical spastic paraparesis</subject><subject>Viruses</subject><subject>Zoology</subject><issn>0250-5991</issn><issn>0973-7138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kEFLwzAYhoMobk5_gBcJePES_ZK0TeJBGUOdMPAyvYZsSeZG185kRfbvTelUEMwlIXm-Ny8PQucUrimAuImUAZcEqCRKSEHUAeqDEpwIyuVhOrMcSK4U7aGTGFcAVGUcjlGPAwPBGeuju_F08kboLR7i4EyJN2b7Xi9cheuADQ5NZT7NDi8aF7e49unKLqMz0Vk8d2V5f4qOvCmjO9vvA_T6-DAdjcnk5el5NJyQORdsSyR4Jw1Y7_O0Ml44mimT20J5STkUWV4UlrLcgc2E5VyIbGatMDMuLIVc8gG66nI3of5oy-j1MrYNTOXqJmpGgSnGhOAJvfyDruomVKmdZiCZVCmupWhHzUMdY3Beb8JybcJOU9CtXN3J1UmubuVqlWYu9snNbO3sz8S3zQSwDojpqVq48Pv1_6lfpBmAKw</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Kanzaki, L I B</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H99</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.F</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>HTLV-1: A real pathogen or a runaway guest of a diseased cell?</title><author>Kanzaki, L I B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-80fe8a0dff5555436e149a5d69f813064566d125e0d47d33774bdd7ab37d10583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cell death</topic><topic>Central nervous system diseases</topic><topic>Environmental factors</topic><topic>Epidemiology</topic><topic>Genomes</topic><topic>Geographical coordinates</topic><topic>Hereditary spastic paraplegia</topic><topic>HTLV-I Infections - epidemiology</topic><topic>HTLV-I Infections - genetics</topic><topic>HTLV-I Infections - virology</topic><topic>Human T-lymphotropic virus 1 - genetics</topic><topic>Human T-lymphotropic virus 1 - pathogenicity</topic><topic>Human T-lymphotropic virus 1 - radiation effects</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia-Lymphoma, Adult T-Cell - epidemiology</topic><topic>Leukemia-Lymphoma, Adult T-Cell - genetics</topic><topic>Leukemia-Lymphoma, Adult T-Cell - virology</topic><topic>Life Sciences</topic><topic>Lymphocytes T</topic><topic>Lymphoma</topic><topic>Microbiology</topic><topic>Minority & ethnic groups</topic><topic>Paraparesis, Tropical Spastic - epidemiology</topic><topic>Paraparesis, Tropical Spastic - genetics</topic><topic>Paraparesis, Tropical Spastic - virology</topic><topic>Pathogens</topic><topic>Plant Sciences</topic><topic>Radiation, Ionizing</topic><topic>Review</topic><topic>Spinal cord</topic><topic>Tropical climate</topic><topic>Tropical spastic paraparesis</topic><topic>Viruses</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kanzaki, L I B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kanzaki, L I B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HTLV-1: A real pathogen or a runaway guest of a diseased cell?</atitle><jtitle>Journal of biosciences</jtitle><stitle>J Biosci</stitle><addtitle>J Biosci</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>43</volume><issue>4</issue><spage>785</spage><epage>795</epage><pages>785-795</pages><issn>0250-5991</issn><eissn>0973-7138</eissn><abstract>The human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus claimed to be aetiologically linked to the adult T-cell leukaemia/lymphoma (ATLL) and associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other minor pathologies. HTLV-1 infection is worldwide distributed, despite its heterogeneous prevalence. Environmental factors and host-genetic background are very likely to determine the epidemiological profile of HTLV-1 prevalence and related disease confinement in distinct human ethnic populations and geographical coordinates, which raises the question if the virus is a real pathogen or a runaway well-organized packed genome of a burden host cell near death process. New methodological approaches need to be proposed and applied in order to prove or discard the hypotheses emerged in the present review.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>30207322</pmid><doi>10.1007/s12038-018-9787-9</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-5991 |
| ispartof | Journal of biosciences, 2018-09, Vol.43 (4), p.785-795 |
| issn | 0250-5991 0973-7138 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2102922773 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerNature Journals; Indian Academy of Sciences |
| subjects | Biomedical and Life Sciences Biomedicine Cell Biology Cell death Central nervous system diseases Environmental factors Epidemiology Genomes Geographical coordinates Hereditary spastic paraplegia HTLV-I Infections - epidemiology HTLV-I Infections - genetics HTLV-I Infections - virology Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - pathogenicity Human T-lymphotropic virus 1 - radiation effects Humans Leukemia Leukemia-Lymphoma, Adult T-Cell - epidemiology Leukemia-Lymphoma, Adult T-Cell - genetics Leukemia-Lymphoma, Adult T-Cell - virology Life Sciences Lymphocytes T Lymphoma Microbiology Minority & ethnic groups Paraparesis, Tropical Spastic - epidemiology Paraparesis, Tropical Spastic - genetics Paraparesis, Tropical Spastic - virology Pathogens Plant Sciences Radiation, Ionizing Review Spinal cord Tropical climate Tropical spastic paraparesis Viruses Zoology |
| title | HTLV-1: A real pathogen or a runaway guest of a diseased cell? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T15%3A53%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HTLV-1:%20A%20real%20pathogen%20or%20a%20runaway%20guest%20of%20a%20diseased%20cell?&rft.jtitle=Journal%20of%20biosciences&rft.au=Kanzaki,%20L%20I%20B&rft.date=2018-09-01&rft.volume=43&rft.issue=4&rft.spage=785&rft.epage=795&rft.pages=785-795&rft.issn=0250-5991&rft.eissn=0973-7138&rft_id=info:doi/10.1007/s12038-018-9787-9&rft_dat=%3Cproquest_cross%3E2102922773%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2082895833&rft_id=info:pmid/30207322&rfr_iscdi=true |