Tandem Palladium-Catalyzed 6-exo-dig Oxocyclization Coupling of δ‑Acetylenic β‑Ketoesters with Aryl Bromides and Chlorides: Route to Substituted Dihydropyrans

We report an efficient and functional group-tolerant method for the synthesis of substituted dihydropyrans, based on tandem Pd-catalyzed cyclization/coupling of δ-acetylenic β-ketoesters with aryl halides. The reaction proceeds cleanly through 6-exo-dig oxocyclizaton mode, delivering products with v...

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Veröffentlicht in:	Journal of organic chemistry 2018-10, Vol.83 (20), p.12887-12896
Hauptverfasser:	Kołodziejczyk, Agata, Domański, Sylwester, Chaładaj, Wojciech
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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