Liver kinase B1 overexpression controls mycobacterial infection in macrophages via FOXO1/Wnt5a signaling

Mycobacterium tuberculosis (Mtb) is a primary cause of tuberculosis (TB), which has infected more than one‐third of the world’s population. Mtb survival and subsequent inflammation in macrophages are important components of TB. Liver kinase B1 (LKB1) has demonstrated anti‐inflammation effects, but i...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-01, Vol.120 (1), p.224-231
Hauptverfasser:	Cui, Junwei, Li, Mingying, Liu, Weiguo, Zhang, Bianfang, Sun, Bing, Niu, Wenyi, Wang, Yongliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines forkhead box protein O1 Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism Forkhead protein FOXO1 protein Humans Inflammation Interleukin-1beta - metabolism Interleukin-6 - metabolism Interleukins Liver liver kinase B1 LKB1 protein macrophage Macrophages Macrophages - metabolism Macrophages - microbiology Mycobacterium tuberculosis - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Signal Transduction Survival Transfection Tuberculosis Tuberculosis - metabolism Tumor Necrosis Factor-alpha - metabolism U937 Cells Wnt protein Wnt-5a Protein - genetics Wnt-5a Protein - metabolism
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