Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

•The protein level of GPX4 in brain tissues was decreased at 24 h after ICH.•Over-expression of GPX4 can alleviate brain injury induced by ICH.•Blockade ferroptosis by Ferrostatin-1 improved brain injury after ICH.•Decreased GPX4 may contribute to SBI after ICH by mediating ferroptosis. Oxidative st...

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Veröffentlicht in:	Brain research 2018-12, Vol.1701, p.112-125
Hauptverfasser:	Zhang, Zhuwei, Wu, Yu, Yuan, Shuai, Zhang, Peng, Zhang, Juyi, Li, Haiying, Li, Xiang, Shen, Haitao, Wang, Zhong, Chen, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Ferroptosis Glutathione peroxidase 4 Intracerebral hemorrhage Reactive oxygen species Secondary brain injury
Online-Zugang:	Volltext
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