Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe ( Aloe barberae)
In recent times, many products ranging from aloe drinks to aloe gels, powders, capsules, and creams have appeared on the commercial market prepared from different aloe species including Aloe barberae. These products are used in ethnomedicine to treat various conditions including gastrointestinal dis...
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| Veröffentlicht in: | Journal of ethnopharmacology 2009-07, Vol.124 (3), p.404-408 |
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| creator | Ndhlala, A.R. Amoo, S.O. Stafford, G.I. Finnie, J.F. Van Staden, J. |
| description | In recent times, many products ranging from aloe drinks to aloe gels, powders, capsules, and creams have appeared on the commercial market prepared from different aloe species including
Aloe barberae. These products are used in ethnomedicine to treat various conditions including gastrointestinal disorders, insect bites, skin burns and other skin injuries by traditional communities.
This study was aimed at evaluating the antibacterial, antifungal and anti-inflammatory activities as well as genotoxic effects of different extracts of
Aloe barberae.
Organic and water extracts of the upper stem, young bark, mature bark, leaves and roots of the South African tree aloe (
Aloe barberae) were evaluated for their antimicrobial [Gram-positive (
Bacillus subtilis and
Staphylococcus aureus), Gram-negative (
Escherichia coli and
Klebsiella pneumoniae) bacteria as well as the fungus
Candida albicans], anti-inflammatory (COX-1 and COX-2) and mutagenic properties (Ames test). Thin layer chromatography (TLC) was used to compare the phytochemical profiles of different extracts of
Aloe barberae.
The petroleum ether (PE) and dichloromethane (DCM) extracts of the mature bark, leaves and roots exhibited good activity against all the bacteria and fungus
Candida albicans with minimum inhibitory concentrations (MIC) ranging from 0.195 to 1.56
mg/ml. All the PE extracts evaluated showed a high activity (>70%) in both COX-1 and COX-2 assays. Apart from the organic extracts of the root with consistently good activity (>70%), all the remaining extracts showed moderate activity (40–69%) in COX-1 assay. The PE extracts also showed a dose dependent increase in activity. Ultraviolet (UV) spectrum of the leaves and root EtOH extracts indicated the presence of compounds that could absorb UV light (wavelength: 190–820
nm). None of the extracts had a mutagenic effect in the
Salmonella/microsome assay against a tester strain, TA98.
Activity observed in the bark, leaves and roots of
Aloe barberae validates its use in commercial herbal products, ethnobotany and ethnoveterinary medicine by South African communities and small scale farmers to treat various conditions. |
| doi_str_mv | 10.1016/j.jep.2009.05.037 |
| format | Article |
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Aloe barberae. These products are used in ethnomedicine to treat various conditions including gastrointestinal disorders, insect bites, skin burns and other skin injuries by traditional communities.
This study was aimed at evaluating the antibacterial, antifungal and anti-inflammatory activities as well as genotoxic effects of different extracts of
Aloe barberae.
Organic and water extracts of the upper stem, young bark, mature bark, leaves and roots of the South African tree aloe (
Aloe barberae) were evaluated for their antimicrobial [Gram-positive (
Bacillus subtilis and
Staphylococcus aureus), Gram-negative (
Escherichia coli and
Klebsiella pneumoniae) bacteria as well as the fungus
Candida albicans], anti-inflammatory (COX-1 and COX-2) and mutagenic properties (Ames test). Thin layer chromatography (TLC) was used to compare the phytochemical profiles of different extracts of
Aloe barberae.
The petroleum ether (PE) and dichloromethane (DCM) extracts of the mature bark, leaves and roots exhibited good activity against all the bacteria and fungus
Candida albicans with minimum inhibitory concentrations (MIC) ranging from 0.195 to 1.56
mg/ml. All the PE extracts evaluated showed a high activity (>70%) in both COX-1 and COX-2 assays. Apart from the organic extracts of the root with consistently good activity (>70%), all the remaining extracts showed moderate activity (40–69%) in COX-1 assay. The PE extracts also showed a dose dependent increase in activity. Ultraviolet (UV) spectrum of the leaves and root EtOH extracts indicated the presence of compounds that could absorb UV light (wavelength: 190–820
nm). None of the extracts had a mutagenic effect in the
Salmonella/microsome assay against a tester strain, TA98.
Activity observed in the bark, leaves and roots of
Aloe barberae validates its use in commercial herbal products, ethnobotany and ethnoveterinary medicine by South African communities and small scale farmers to treat various conditions.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2009.05.037</identifier><identifier>PMID: 19505552</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aloe ; Aloe - chemistry ; Aloe barberae ; Ames test ; Animals ; Anti-Infective Agents - pharmacology ; Anti-inflammatory ; anti-inflammatory activity ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antibacterial ; Antifungal ; antimicrobial properties ; Bacteria - drug effects ; bark ; Biological and medical sciences ; Candida albicans ; Chromatography, Thin Layer ; Cyclooxygenase Inhibitors - pharmacology ; dosage ; dose response ; Dose-Response Relationship, Drug ; Ethnomedicine ; Fungi - drug effects ; General pharmacology ; genotoxicity ; Gram-negative bacteria ; Gram-positive bacteria ; herbal medicines ; In Vitro Techniques ; leaves ; Medical sciences ; medicinal plants ; medicinal properties ; Microbial Sensitivity Tests ; minimum inhibitory concentration ; mutagenesis ; Mutagenicity ; Mutagens - toxicity ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phenols - chemistry ; Phenols - pharmacology ; phytochemicals ; plant extracts ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; prostaglandin synthase ; Rats ; Risk ; roots ; Salmonella typhimurium - drug effects ; Salmonella typhimurium - genetics ; South Africa ; Spectrophotometry, Ultraviolet ; Tree aloe</subject><ispartof>Journal of ethnopharmacology, 2009-07, Vol.124 (3), p.404-408</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-3fb18c6fd0abe916437d8d1f76ba973751f246016f362bdfe8d07aa9d1ef74703</citedby><cites>FETCH-LOGICAL-c534t-3fb18c6fd0abe916437d8d1f76ba973751f246016f362bdfe8d07aa9d1ef74703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874109003377$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21879768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19505552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ndhlala, A.R.</creatorcontrib><creatorcontrib>Amoo, S.O.</creatorcontrib><creatorcontrib>Stafford, G.I.</creatorcontrib><creatorcontrib>Finnie, J.F.</creatorcontrib><creatorcontrib>Van Staden, J.</creatorcontrib><title>Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe ( Aloe barberae)</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>In recent times, many products ranging from aloe drinks to aloe gels, powders, capsules, and creams have appeared on the commercial market prepared from different aloe species including
Aloe barberae. These products are used in ethnomedicine to treat various conditions including gastrointestinal disorders, insect bites, skin burns and other skin injuries by traditional communities.
This study was aimed at evaluating the antibacterial, antifungal and anti-inflammatory activities as well as genotoxic effects of different extracts of
Aloe barberae.
Organic and water extracts of the upper stem, young bark, mature bark, leaves and roots of the South African tree aloe (
Aloe barberae) were evaluated for their antimicrobial [Gram-positive (
Bacillus subtilis and
Staphylococcus aureus), Gram-negative (
Escherichia coli and
Klebsiella pneumoniae) bacteria as well as the fungus
Candida albicans], anti-inflammatory (COX-1 and COX-2) and mutagenic properties (Ames test). Thin layer chromatography (TLC) was used to compare the phytochemical profiles of different extracts of
Aloe barberae.
The petroleum ether (PE) and dichloromethane (DCM) extracts of the mature bark, leaves and roots exhibited good activity against all the bacteria and fungus
Candida albicans with minimum inhibitory concentrations (MIC) ranging from 0.195 to 1.56
mg/ml. All the PE extracts evaluated showed a high activity (>70%) in both COX-1 and COX-2 assays. Apart from the organic extracts of the root with consistently good activity (>70%), all the remaining extracts showed moderate activity (40–69%) in COX-1 assay. The PE extracts also showed a dose dependent increase in activity. Ultraviolet (UV) spectrum of the leaves and root EtOH extracts indicated the presence of compounds that could absorb UV light (wavelength: 190–820
nm). None of the extracts had a mutagenic effect in the
Salmonella/microsome assay against a tester strain, TA98.
Activity observed in the bark, leaves and roots of
Aloe barberae validates its use in commercial herbal products, ethnobotany and ethnoveterinary medicine by South African communities and small scale farmers to treat various conditions.</description><subject>Aloe</subject><subject>Aloe - chemistry</subject><subject>Aloe barberae</subject><subject>Ames test</subject><subject>Animals</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-inflammatory</subject><subject>anti-inflammatory activity</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antibacterial</subject><subject>Antifungal</subject><subject>antimicrobial properties</subject><subject>Bacteria - drug effects</subject><subject>bark</subject><subject>Biological and medical sciences</subject><subject>Candida albicans</subject><subject>Chromatography, Thin Layer</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>dosage</subject><subject>dose response</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethnomedicine</subject><subject>Fungi - drug effects</subject><subject>General pharmacology</subject><subject>genotoxicity</subject><subject>Gram-negative bacteria</subject><subject>Gram-positive bacteria</subject><subject>herbal medicines</subject><subject>In Vitro Techniques</subject><subject>leaves</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Microbial Sensitivity Tests</subject><subject>minimum inhibitory concentration</subject><subject>mutagenesis</subject><subject>Mutagenicity</subject><subject>Mutagens - toxicity</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phenols - chemistry</subject><subject>Phenols - pharmacology</subject><subject>phytochemicals</subject><subject>plant extracts</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>prostaglandin synthase</subject><subject>Rats</subject><subject>Risk</subject><subject>roots</subject><subject>Salmonella typhimurium - drug effects</subject><subject>Salmonella typhimurium - genetics</subject><subject>South Africa</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tree aloe</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvhB3ABX6AgkWWcxHEiTquqfEiVOJSerYkz3nqVxFvbqdR_j1e7gltPI4-eGY-el7G3AtYCRPN1t97Rfl0CdGuQa6jUM7YSrSoLJVX1nK1ypy1aVYsz9irGHQAoUcNLdiY6CVLKcsXGzZzc5EzwvcPxC8f8LNxsR5wmTD485s7ApyXhlmZnuJsfKCa3xeT8zL3l6Y74jV_SHd_Y4AzOPAUijqMn_olvDqXH0FNA-vyavbA4Rnpzqufs9vvVn8ufxfXvH78uN9eFkVWdisr2ojWNHQB76kRTV2poB2FV02OnKiWFLesmC7BVU_aDpXYAhdgNgqyqFVTn7OK4dx_8_ZLv1ZOLhsYRZ_JL1EqJtoO2kZn8-CRZCihlJw6gOILZVIyBrN4HN2F41AL0IQy90zkMfQhDg9RZfZ55d1q-9BMN_ydO9jPw4QRgNDjagLNx8R9X5iw71bSZe3_kLHqN25CZ25sSRJX_baCrRSa-HQnKWh8cBR2No9nQ4AKZpAfvnjj0L9j1sGk</recordid><startdate>20090730</startdate><enddate>20090730</enddate><creator>Ndhlala, A.R.</creator><creator>Amoo, S.O.</creator><creator>Stafford, G.I.</creator><creator>Finnie, J.F.</creator><creator>Van Staden, J.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20090730</creationdate><title>Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe ( Aloe barberae)</title><author>Ndhlala, A.R. ; Amoo, S.O. ; Stafford, G.I. ; Finnie, J.F. ; Van Staden, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-3fb18c6fd0abe916437d8d1f76ba973751f246016f362bdfe8d07aa9d1ef74703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aloe</topic><topic>Aloe - chemistry</topic><topic>Aloe barberae</topic><topic>Ames test</topic><topic>Animals</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-inflammatory</topic><topic>anti-inflammatory activity</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antibacterial</topic><topic>Antifungal</topic><topic>antimicrobial properties</topic><topic>Bacteria - drug effects</topic><topic>bark</topic><topic>Biological and medical sciences</topic><topic>Candida albicans</topic><topic>Chromatography, Thin Layer</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>dosage</topic><topic>dose response</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethnomedicine</topic><topic>Fungi - drug effects</topic><topic>General pharmacology</topic><topic>genotoxicity</topic><topic>Gram-negative bacteria</topic><topic>Gram-positive bacteria</topic><topic>herbal medicines</topic><topic>In Vitro Techniques</topic><topic>leaves</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Microbial Sensitivity Tests</topic><topic>minimum inhibitory concentration</topic><topic>mutagenesis</topic><topic>Mutagenicity</topic><topic>Mutagens - toxicity</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phenols - chemistry</topic><topic>Phenols - pharmacology</topic><topic>phytochemicals</topic><topic>plant extracts</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>prostaglandin synthase</topic><topic>Rats</topic><topic>Risk</topic><topic>roots</topic><topic>Salmonella typhimurium - drug effects</topic><topic>Salmonella typhimurium - genetics</topic><topic>South Africa</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tree aloe</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ndhlala, A.R.</creatorcontrib><creatorcontrib>Amoo, S.O.</creatorcontrib><creatorcontrib>Stafford, G.I.</creatorcontrib><creatorcontrib>Finnie, J.F.</creatorcontrib><creatorcontrib>Van Staden, J.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ndhlala, A.R.</au><au>Amoo, S.O.</au><au>Stafford, G.I.</au><au>Finnie, J.F.</au><au>Van Staden, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe ( Aloe barberae)</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-07-30</date><risdate>2009</risdate><volume>124</volume><issue>3</issue><spage>404</spage><epage>408</epage><pages>404-408</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>In recent times, many products ranging from aloe drinks to aloe gels, powders, capsules, and creams have appeared on the commercial market prepared from different aloe species including
Aloe barberae. These products are used in ethnomedicine to treat various conditions including gastrointestinal disorders, insect bites, skin burns and other skin injuries by traditional communities.
This study was aimed at evaluating the antibacterial, antifungal and anti-inflammatory activities as well as genotoxic effects of different extracts of
Aloe barberae.
Organic and water extracts of the upper stem, young bark, mature bark, leaves and roots of the South African tree aloe (
Aloe barberae) were evaluated for their antimicrobial [Gram-positive (
Bacillus subtilis and
Staphylococcus aureus), Gram-negative (
Escherichia coli and
Klebsiella pneumoniae) bacteria as well as the fungus
Candida albicans], anti-inflammatory (COX-1 and COX-2) and mutagenic properties (Ames test). Thin layer chromatography (TLC) was used to compare the phytochemical profiles of different extracts of
Aloe barberae.
The petroleum ether (PE) and dichloromethane (DCM) extracts of the mature bark, leaves and roots exhibited good activity against all the bacteria and fungus
Candida albicans with minimum inhibitory concentrations (MIC) ranging from 0.195 to 1.56
mg/ml. All the PE extracts evaluated showed a high activity (>70%) in both COX-1 and COX-2 assays. Apart from the organic extracts of the root with consistently good activity (>70%), all the remaining extracts showed moderate activity (40–69%) in COX-1 assay. The PE extracts also showed a dose dependent increase in activity. Ultraviolet (UV) spectrum of the leaves and root EtOH extracts indicated the presence of compounds that could absorb UV light (wavelength: 190–820
nm). None of the extracts had a mutagenic effect in the
Salmonella/microsome assay against a tester strain, TA98.
Activity observed in the bark, leaves and roots of
Aloe barberae validates its use in commercial herbal products, ethnobotany and ethnoveterinary medicine by South African communities and small scale farmers to treat various conditions.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19505552</pmid><doi>10.1016/j.jep.2009.05.037</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2009-07, Vol.124 (3), p.404-408 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| subjects | Aloe Aloe - chemistry Aloe barberae Ames test Animals Anti-Infective Agents - pharmacology Anti-inflammatory anti-inflammatory activity Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibacterial Antifungal antimicrobial properties Bacteria - drug effects bark Biological and medical sciences Candida albicans Chromatography, Thin Layer Cyclooxygenase Inhibitors - pharmacology dosage dose response Dose-Response Relationship, Drug Ethnomedicine Fungi - drug effects General pharmacology genotoxicity Gram-negative bacteria Gram-positive bacteria herbal medicines In Vitro Techniques leaves Medical sciences medicinal plants medicinal properties Microbial Sensitivity Tests minimum inhibitory concentration mutagenesis Mutagenicity Mutagens - toxicity Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phenols - chemistry Phenols - pharmacology phytochemicals plant extracts Plant Extracts - chemistry Plant Extracts - pharmacology prostaglandin synthase Rats Risk roots Salmonella typhimurium - drug effects Salmonella typhimurium - genetics South Africa Spectrophotometry, Ultraviolet Tree aloe |
| title | Antimicrobial, anti-inflammatory and mutagenic investigation of the South African tree aloe ( Aloe barberae) |
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