Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety data

The broadly neutralizing recombinant human HIV-1 antibodies 4E10, 2F5 and Igh1b12 are reported to have autoreactive potential, which is significant for HIV-1 vaccine development and passive immunotherapy using these antibodies. To investigate the clinical relevance of these findings in subjects rece...

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Veröffentlicht in:	AIDS (London) 2007-10, Vol.21 (16), p.2161-2170
Hauptverfasser:	VCELAR, Brigitta, STIEGLER, Gabriela, KATINGER, Hermann, WOLF, Hermann M, MUNTEAN, Wolfgang, LESCHNIK, Bettina, MEHANDRU, Saurabh, MARKOWITZ, Martin, ARMBRUSTER, Christine, KUNERT, Renate, EIBL, Martha M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibody Specificity Biological and medical sciences Blood and lymphatic vessels Blood Coagulation Tests Cardiolipins - immunology Cardiology. Vascular system Clinical Trials as Topic Cross Reactions Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dose-Response Relationship, Immunologic Drug-Related Side Effects and Adverse Reactions Enzyme-Linked Immunosorbent Assay Female HIV Antibodies - administration & dosage HIV Antibodies - immunology Human immunodeficiency virus 1 Human viral diseases Humans Immunization, Passive - adverse effects Immunization, Passive - methods Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunologic Factors - administration & dosage Immunologic Factors - immunology Immunopathology Infant, Newborn Infectious diseases Male Medical sciences Phosphatidylserines - immunology Prothrombin - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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