Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing lung disease with a dismal prognosis and a largely unknown etiology. Autotaxin (ATX) is a secreted lysophospholipase D, largely responsible for extracellular production of lysophosphatidic acid (LPA), a bioactive phospholipid. LPA has numero...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Pulmonary pharmacology & therapeutics 2018-10, Vol.52, p.32-40
Hauptverfasser:	Ninou, Ioanna, Kaffe, Eleanna, Müller, Stefan, Budd, David C., Stevenson, Christopher S., Ullmer, Christoph, Aidinis, Vassilis
Format:	Artikel
Sprache:	eng
Schlagworte:	Autotaxin (ATX) Lysophosphatidic acid (LPA) Lysophosphatidic acid receptor 1 (LPAR1) Lysophospholipase D Pulmonary fibrosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!