Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats

Enterally administered riluzole is currently being investigated in a Phase II/III clinical trial for the treatment of acute spinal cord injury (SCI). Many SCI patients suffer from severe motor dysfunction and exhibit swallowing difficulties and cannot swallow riluzole tablets. The purpose of the pre...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2018-12, Vol.125, p.1-10
Hauptverfasser:	Sarkar, Mahua, Grossman, Robert G., Toups, Elizabeth G., Chow, Diana S-L
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Administration, Oral Animals Brain - metabolism Central Composite Design Co-solvent Drug Design Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - chemistry Excitatory Amino Acid Antagonists - pharmacokinetics Glycerol - administration & dosage Glycerol - chemistry Glycerol - pharmacokinetics Hemolytic potential Intravenous Male Oral Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Propylene Glycol - administration & dosage Propylene Glycol - chemistry Propylene Glycol - pharmacokinetics Rats, Sprague-Dawley Riluzole Riluzole - administration & dosage Riluzole - chemistry Riluzole - pharmacokinetics Sodium Channel Blockers - administration & dosage Sodium Channel Blockers - chemistry Sodium Channel Blockers - pharmacokinetics Solvents - administration & dosage Solvents - chemistry Solvents - pharmacokinetics Spinal Cord - metabolism
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