Recent Advances in the Studies of Molecular Mechanisms Regulating Multidrug Resistance in Cancer Cells
—Here we present new approaches to better understanding multidrug resistance (MDR) development in cancer cells, such as identification of components of a complex process of MDR evolution. Recent advances in the studies of MDR are discussed: 1) chemotherapy agents might be involved in the selection o...
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| Veröffentlicht in: | Biochemistry (Moscow) 2018-07, Vol.83 (7), p.779-786 |
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| container_title | Biochemistry (Moscow) |
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| creator | Stavrovskaya, A. A. Rybalkina, E. Yu |
| description | —Here we present new approaches to better understanding multidrug resistance (MDR) development in cancer cells, such as identification of components of a complex process of MDR evolution. Recent advances in the studies of MDR are discussed: 1) chemotherapy agents might be involved in the selection of cancer stem cells resulting in the elevated drug resistance and enhanced tumorigenicity; 2) cell–cell interactions have a great effect on the MDR emergence and evolution; 3) mechanotransduction is an important signaling mechanism in cell–cell interactions; 4) proteins of the ABC transporter family which are often involved in MDR might be transferred between cells via microvesicles (epigenetic MDR regulation); 5) proteins providing cell-to-cell transfer of functional P-glycoprotein (MDR1 protein) via microvesicles have been investigated; 6) P-glycoprotein may serve to regulate apoptosis, as well as transcription and translation of target genes/proteins. Although proving once again that MDR is a complex multi-faceted process, these data open new approaches to overcoming it. |
| doi_str_mv | 10.1134/S0006297918070015 |
| format | Article |
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Recent advances in the studies of MDR are discussed: 1) chemotherapy agents might be involved in the selection of cancer stem cells resulting in the elevated drug resistance and enhanced tumorigenicity; 2) cell–cell interactions have a great effect on the MDR emergence and evolution; 3) mechanotransduction is an important signaling mechanism in cell–cell interactions; 4) proteins of the ABC transporter family which are often involved in MDR might be transferred between cells via microvesicles (epigenetic MDR regulation); 5) proteins providing cell-to-cell transfer of functional P-glycoprotein (MDR1 protein) via microvesicles have been investigated; 6) P-glycoprotein may serve to regulate apoptosis, as well as transcription and translation of target genes/proteins. 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All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-83afbcff0aa73f3400fce824f721e651023e91c4ad0730edf67545b4a6a47ff33</citedby><cites>FETCH-LOGICAL-c439t-83afbcff0aa73f3400fce824f721e651023e91c4ad0730edf67545b4a6a47ff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297918070015$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297918070015$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30200862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stavrovskaya, A. A.</creatorcontrib><creatorcontrib>Rybalkina, E. Yu</creatorcontrib><title>Recent Advances in the Studies of Molecular Mechanisms Regulating Multidrug Resistance in Cancer Cells</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>—Here we present new approaches to better understanding multidrug resistance (MDR) development in cancer cells, such as identification of components of a complex process of MDR evolution. Recent advances in the studies of MDR are discussed: 1) chemotherapy agents might be involved in the selection of cancer stem cells resulting in the elevated drug resistance and enhanced tumorigenicity; 2) cell–cell interactions have a great effect on the MDR emergence and evolution; 3) mechanotransduction is an important signaling mechanism in cell–cell interactions; 4) proteins of the ABC transporter family which are often involved in MDR might be transferred between cells via microvesicles (epigenetic MDR regulation); 5) proteins providing cell-to-cell transfer of functional P-glycoprotein (MDR1 protein) via microvesicles have been investigated; 6) P-glycoprotein may serve to regulate apoptosis, as well as transcription and translation of target genes/proteins. Although proving once again that MDR is a complex multi-faceted process, these data open new approaches to overcoming it.</description><subject>ABC transporter</subject><subject>Apoptosis</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>ATP-Binding Cassette Transporters - metabolism</subject><subject>Biochemistry</subject><subject>Biological research</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cell Communication - drug effects</subject><subject>Cell interactions</subject><subject>Chemotherapy</subject><subject>Drug resistance</subject><subject>Drug Resistance, Multiple</subject><subject>Drug Resistance, Neoplasm</subject><subject>Evolution</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>MDR1 protein</subject><subject>Mechanotransduction</subject><subject>Microbiology</subject><subject>Molecular chains</subject><subject>Molecular mechanics</subject><subject>Molecular modelling</subject><subject>Multidrug resistance</subject><subject>Multidrug resistant organisms</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Neoplastic Stem Cells - drug effects</subject><subject>Neoplastic Stem Cells - pathology</subject><subject>P-Glycoprotein</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Review</subject><subject>Stem cells</subject><subject>Transcription</subject><subject>Tumorigenicity</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhi0EokvhB3BBlrj0kjL-iJMcVysoSF0htXC2vM44dZU4xU4q8e-xtYWKL_ng-XjfRzMaQl4zOGdMyHfXAKB413SshQaA1U_IhiloKwESnpJNaVelf0JepHSbUw6deE5ORA6gVXxD3BVaDAvd9vcmWEzUB7rcIL1e1t7ndHZ0P49o19FEukd7Y4JPU6JXOOTS4sNA9-u4-D6uQy4mn5bCKZhdCSLd4Timl-SZM2PCVw__Kfn64f2X3cfq8vPFp932srJSdEvVCuMO1jkwphFOSABnseXSNZyhqhlwgR2z0vTQCMDeqaaW9UEaZWTjnBCn5OzIvYvztxXToiefbJ7ABJzXpHlBCN52Rfr2D-ntvMaQp9McVNdAB0o9qgYzovbBzUs0tkD1tq6ZEG3bFtb5P1T59Th5Owd0Ptd_M7CjwcY5pYhO30U_mfhdM9Dltvqv22bPm4eB18OE_S_Hz2NmAT8KUm6FAePjRv-n_gADw6tj</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Stavrovskaya, A. 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Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-83afbcff0aa73f3400fce824f721e651023e91c4ad0730edf67545b4a6a47ff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>ABC transporter</topic><topic>Apoptosis</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>ATP-Binding Cassette Transporters - metabolism</topic><topic>Biochemistry</topic><topic>Biological research</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Cancer</topic><topic>Cancer cells</topic><topic>Cell Communication - drug effects</topic><topic>Cell interactions</topic><topic>Chemotherapy</topic><topic>Drug resistance</topic><topic>Drug Resistance, Multiple</topic><topic>Drug Resistance, Neoplasm</topic><topic>Evolution</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>MDR1 protein</topic><topic>Mechanotransduction</topic><topic>Microbiology</topic><topic>Molecular chains</topic><topic>Molecular mechanics</topic><topic>Molecular modelling</topic><topic>Multidrug resistance</topic><topic>Multidrug resistant organisms</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Neoplastic Stem Cells - drug effects</topic><topic>Neoplastic Stem Cells - pathology</topic><topic>P-Glycoprotein</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Review</topic><topic>Stem cells</topic><topic>Transcription</topic><topic>Tumorigenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stavrovskaya, A. 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| subjects | ABC transporter Apoptosis ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biochemistry Biological research Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Cancer cells Cell Communication - drug effects Cell interactions Chemotherapy Drug resistance Drug Resistance, Multiple Drug Resistance, Neoplasm Evolution Glycoproteins Humans Life Sciences MDR1 protein Mechanotransduction Microbiology Molecular chains Molecular mechanics Molecular modelling Multidrug resistance Multidrug resistant organisms Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology P-Glycoprotein Physiological aspects Proteins Review Stem cells Transcription Tumorigenicity |
| title | Recent Advances in the Studies of Molecular Mechanisms Regulating Multidrug Resistance in Cancer Cells |
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