Polarized microtubule dynamics directs cell mechanics and coordinates forces during epithelial morphogenesis

Coordinated rearrangements of cytoskeletal structures are the principal source of forces that govern cell and tissue morphogenesis 1 , 2 . However, unlike for actin-based mechanical forces, our knowledge about the contribution of forces originating from other cytoskeletal components remains scarce....

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Veröffentlicht in:	Nature cell biology 2018-10, Vol.20 (10), p.1126-1133
Hauptverfasser:	Singh, Amrita, Saha, Tanumoy, Begemann, Isabell, Ricker, Andrea, Nüsse, Harald, Thorn-Seshold, Oliver, Klingauf, Jürgen, Galic, Milos, Matis, Maja
Format:	Artikel
Sprache:	eng
Schlagworte:	14 14/1 14/19 14/28 631/136/1660 631/80/128/1653 631/80/79/2066 Actin Adherens junctions Animals Animals, Genetically Modified Biomedical and Life Sciences Cancer Research Cell Biology Cell Polarity Contractility Cytoskeleton Cytoskeleton - metabolism Developmental Biology Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial Cells - ultrastructure Epithelium Epithelium - growth & development Epithelium - metabolism Fruit flies Letter Life Sciences Luminescent Proteins - genetics Luminescent Proteins - metabolism Mechanics Mechanics (physics) Microscopy, Confocal Microscopy, Electron, Transmission Microtubules Microtubules - metabolism Morphogenesis Muscle proteins Pattern formation Polarity Pupa - cytology Pupa - growth & development Pupa - metabolism Resveratrol Signal transduction Stem Cells Time-Lapse Imaging - methods Tissues Wings, Animal - growth & development Wings, Animal - metabolism
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