NEAT1 induces osteosarcoma development by modulating the miR‐339‐5p/TGF‐β1 pathway

The long noncoding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) has been recognized as a tumor oncogene involved in the development of multiple cancers. However, the function of NEAT1 and its molecular mechanism in osteosarcoma (OS) remain unclear. First, we detected the NEAT1 express...

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Veröffentlicht in:	Journal of cellular physiology 2019-04, Vol.234 (4), p.5097-5105
Hauptverfasser:	Zhang, Lin, Lu, Xiao‐Qing, Zhou, Xiao‐Qing, Liu, Qin‐Bai, Chen, Liang, Cai, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biocompatibility Biomedical materials Bone cancer Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Gene Expression Regulation, Neoplastic Growth factors Humans MicroRNAs - genetics MicroRNAs - metabolism miRNA miR‐339‐5p NEAT1 Neoplasm Invasiveness Osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Polymerase chain reaction Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Sarcoma Signal Transduction TGF‐β1 Therapeutic applications Transforming growth factor Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Tumors
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