LncRNA DSCAM‐AS1 acts as a sponge of miR‐137 to enhance Tamoxifen resistance in breast cancer
Objective To investigate the influence of long noncoding RNA (lncRNA) DSCAM‐AS1 on the propagation and apoptosis of Tamoxifen‐resistant (TR) breast cancer cells via regulation of mircoRNA (miR)‐137 and epidermal growth factor receptor pathway substrate 8 (EPS8). Methods Data of GSE5840 downloaded fr...
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| Veröffentlicht in: | Journal of cellular physiology 2019-03, Vol.234 (3), p.2880-2894 |
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| creator | Ma, Yun Bu, Deyong Long, Jiang Chai, Wenying Dong, Jian |
| description | Objective
To investigate the influence of long noncoding RNA (lncRNA) DSCAM‐AS1 on the propagation and apoptosis of Tamoxifen‐resistant (TR) breast cancer cells via regulation of mircoRNA (miR)‐137 and epidermal growth factor receptor pathway substrate 8 (EPS8).
Methods
Data of GSE5840 downloaded from the Gene Expression Omnibus database were utilized to screen out aberrantly expressed lncRNA and messenger RNA in breast cancer tissue samples. The expressions of DSCAM‐AS1, miR‐137, and EPS8 were determined by quantitative real time polymerase chain reaction (qRT‐PCR). Cell lines were screened by half maximal inhibitory concentration (IC
50). 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay and the flow cytometry assay were used to detect cell proliferation, apoptosis, and cell cycle. The relationship among DSCAM‐AS1, miR‐137, and EPS8 was studied by miRcode, TargetScan, and Pearson correlation coefficient. A xenograft mouse model experiment was performed to demonstrate the effect of DSCAM‐AS1 and EPS8 on tumor growth in vivo.
Results
LncRNA DSCAM‐AS1 and EPS8 were significantly upregulated, whereas miR‐137 was downregulated in TR tissues. DSCAM‐AS1 could promote the Tamoxifen resistance of breast cancer, and it was negatively correlated with miR‐137, whereas positively correlated with the expression of EPS8 in TR breast cancer tissues. Furthermore, miR‐137 could inhibit tumor development and arrest cell cycle at the G0/G1 phase by targeting the 3′‐UTR of EPS8. DSCAM‐AS1 targeted miR‐137 and EPS8 to promote propagation of TR breast cancer cells and inhibit cell apoptosis.
Conclusion
LncRNA DSCAM‐AS1 acts as a competing endogenous RNA of miR‐137 and regulates EPS8 to promote cell reproduction and suppresses cell apoptosis in TR breast cancer.
1.DSCAM‐AS1 could modulate the expression of epidermal growth factor receptor pathway substrate 8 (EPS8) through mircoRNA (miR)‐137 in breast cancer cells, promote Tamoxifen resistance, propagation, and metastasis of cells in breast cancer, and inhibit cell apoptosis.
2.The DSCAM‐AS1/miR‐137/EPS8 axis may provide new therapeutic targets for Tamoxifen‐resistant breast cancer. |
| doi_str_mv | 10.1002/jcp.27105 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2102319710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2139435943</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4195-5fb0ac9abeb9a4a395c955c3c532f22ee462c8a69dd29270dd5bfb6d5dc0c81c3</originalsourceid><addsrcrecordid>eNp1kN1KwzAYhoMobk4PvAEJeKIH3fLTtOZw1H_mD9s8Lmmaakfb1KRFd-YleI1eidk6PRCEhPB978NLeAA4xGiIESKjhayHJMSIbYE-Rjz0_ICRbdB3GfY483EP7Fm7QAhxTuku6FFEEA0w6wMxqeT0fgzPZ9H47uvjczzDUMjGQuEOtLWunhXUGSzzqUsxDWGjoapeRCUVnItSv-eZqqBRNrfNeplXMDFK2AbK1Wz2wU4mCqsONu8APF1ezKNrb_JwdRONJ570MWceyxIkJBeJSrjwBeVMcsYklYySjBCl_IDIMxHwNCWchChNWZIlQcpSieQZlnQATrre2ujXVtkmLnMrVVGISunWxgQjQjF3mhx6_Add6NZU7neOotynzF1HnXaUNNpao7K4NnkpzDLGKF55j533eO3dsUebxjYpVfpL_oh2wKgD3vJCLf9vim-jx67yG20di6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2139435943</pqid></control><display><type>article</type><title>LncRNA DSCAM‐AS1 acts as a sponge of miR‐137 to enhance Tamoxifen resistance in breast cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Ma, Yun ; Bu, Deyong ; Long, Jiang ; Chai, Wenying ; Dong, Jian</creator><creatorcontrib>Ma, Yun ; Bu, Deyong ; Long, Jiang ; Chai, Wenying ; Dong, Jian</creatorcontrib><description>Objective
To investigate the influence of long noncoding RNA (lncRNA) DSCAM‐AS1 on the propagation and apoptosis of Tamoxifen‐resistant (TR) breast cancer cells via regulation of mircoRNA (miR)‐137 and epidermal growth factor receptor pathway substrate 8 (EPS8).
Methods
Data of GSE5840 downloaded from the Gene Expression Omnibus database were utilized to screen out aberrantly expressed lncRNA and messenger RNA in breast cancer tissue samples. The expressions of DSCAM‐AS1, miR‐137, and EPS8 were determined by quantitative real time polymerase chain reaction (qRT‐PCR). Cell lines were screened by half maximal inhibitory concentration (IC
50). 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay and the flow cytometry assay were used to detect cell proliferation, apoptosis, and cell cycle. The relationship among DSCAM‐AS1, miR‐137, and EPS8 was studied by miRcode, TargetScan, and Pearson correlation coefficient. A xenograft mouse model experiment was performed to demonstrate the effect of DSCAM‐AS1 and EPS8 on tumor growth in vivo.
Results
LncRNA DSCAM‐AS1 and EPS8 were significantly upregulated, whereas miR‐137 was downregulated in TR tissues. DSCAM‐AS1 could promote the Tamoxifen resistance of breast cancer, and it was negatively correlated with miR‐137, whereas positively correlated with the expression of EPS8 in TR breast cancer tissues. Furthermore, miR‐137 could inhibit tumor development and arrest cell cycle at the G0/G1 phase by targeting the 3′‐UTR of EPS8. DSCAM‐AS1 targeted miR‐137 and EPS8 to promote propagation of TR breast cancer cells and inhibit cell apoptosis.
Conclusion
LncRNA DSCAM‐AS1 acts as a competing endogenous RNA of miR‐137 and regulates EPS8 to promote cell reproduction and suppresses cell apoptosis in TR breast cancer.
1.DSCAM‐AS1 could modulate the expression of epidermal growth factor receptor pathway substrate 8 (EPS8) through mircoRNA (miR)‐137 in breast cancer cells, promote Tamoxifen resistance, propagation, and metastasis of cells in breast cancer, and inhibit cell apoptosis.
2.The DSCAM‐AS1/miR‐137/EPS8 axis may provide new therapeutic targets for Tamoxifen‐resistant breast cancer.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27105</identifier><identifier>PMID: 30203615</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>3' Untranslated regions ; Adaptor Proteins, Signal Transducing - genetics ; Animals ; Apoptosis ; Apoptosis - drug effects ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer ; Cell cycle ; Cell Line, Tumor ; Cell proliferation ; Cell Proliferation - drug effects ; Correlation coefficient ; Correlation coefficients ; Drug Resistance, Neoplasm - genetics ; DSCAM protein ; DSCAM‐AS1 ; Epidermal growth factor ; epidermal growth factor receptor pathway substrate 8 (EPS8) ; Female ; Flow cytometry ; G1 phase ; Gene expression ; Gene Expression Regulation, Neoplastic - drug effects ; Growth factors ; Humans ; Mice ; MicroRNAs - genetics ; mircoRNA‐137 (miR‐137) ; mRNA ; Neural cell adhesion molecule ; Polymerase chain reaction ; Ribonucleic acid ; RNA ; RNA, Long Noncoding - genetics ; Substrates ; Tamoxifen ; Tamoxifen - adverse effects ; Tamoxifen - pharmacology ; Tumors ; Xenograft Model Antitumor Assays ; Xenografts ; Xenotransplantation</subject><ispartof>Journal of cellular physiology, 2019-03, Vol.234 (3), p.2880-2894</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4195-5fb0ac9abeb9a4a395c955c3c532f22ee462c8a69dd29270dd5bfb6d5dc0c81c3</citedby><cites>FETCH-LOGICAL-c4195-5fb0ac9abeb9a4a395c955c3c532f22ee462c8a69dd29270dd5bfb6d5dc0c81c3</cites><orcidid>0000-0002-3321-7404</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27105$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27105$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30203615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Yun</creatorcontrib><creatorcontrib>Bu, Deyong</creatorcontrib><creatorcontrib>Long, Jiang</creatorcontrib><creatorcontrib>Chai, Wenying</creatorcontrib><creatorcontrib>Dong, Jian</creatorcontrib><title>LncRNA DSCAM‐AS1 acts as a sponge of miR‐137 to enhance Tamoxifen resistance in breast cancer</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Objective
To investigate the influence of long noncoding RNA (lncRNA) DSCAM‐AS1 on the propagation and apoptosis of Tamoxifen‐resistant (TR) breast cancer cells via regulation of mircoRNA (miR)‐137 and epidermal growth factor receptor pathway substrate 8 (EPS8).
Methods
Data of GSE5840 downloaded from the Gene Expression Omnibus database were utilized to screen out aberrantly expressed lncRNA and messenger RNA in breast cancer tissue samples. The expressions of DSCAM‐AS1, miR‐137, and EPS8 were determined by quantitative real time polymerase chain reaction (qRT‐PCR). Cell lines were screened by half maximal inhibitory concentration (IC
50). 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay and the flow cytometry assay were used to detect cell proliferation, apoptosis, and cell cycle. The relationship among DSCAM‐AS1, miR‐137, and EPS8 was studied by miRcode, TargetScan, and Pearson correlation coefficient. A xenograft mouse model experiment was performed to demonstrate the effect of DSCAM‐AS1 and EPS8 on tumor growth in vivo.
Results
LncRNA DSCAM‐AS1 and EPS8 were significantly upregulated, whereas miR‐137 was downregulated in TR tissues. DSCAM‐AS1 could promote the Tamoxifen resistance of breast cancer, and it was negatively correlated with miR‐137, whereas positively correlated with the expression of EPS8 in TR breast cancer tissues. Furthermore, miR‐137 could inhibit tumor development and arrest cell cycle at the G0/G1 phase by targeting the 3′‐UTR of EPS8. DSCAM‐AS1 targeted miR‐137 and EPS8 to promote propagation of TR breast cancer cells and inhibit cell apoptosis.
Conclusion
LncRNA DSCAM‐AS1 acts as a competing endogenous RNA of miR‐137 and regulates EPS8 to promote cell reproduction and suppresses cell apoptosis in TR breast cancer.
1.DSCAM‐AS1 could modulate the expression of epidermal growth factor receptor pathway substrate 8 (EPS8) through mircoRNA (miR)‐137 in breast cancer cells, promote Tamoxifen resistance, propagation, and metastasis of cells in breast cancer, and inhibit cell apoptosis.
2.The DSCAM‐AS1/miR‐137/EPS8 axis may provide new therapeutic targets for Tamoxifen‐resistant breast cancer.</description><subject>3' Untranslated regions</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cell cycle</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>DSCAM protein</subject><subject>DSCAM‐AS1</subject><subject>Epidermal growth factor</subject><subject>epidermal growth factor receptor pathway substrate 8 (EPS8)</subject><subject>Female</subject><subject>Flow cytometry</subject><subject>G1 phase</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Mice</subject><subject>MicroRNAs - genetics</subject><subject>mircoRNA‐137 (miR‐137)</subject><subject>mRNA</subject><subject>Neural cell adhesion molecule</subject><subject>Polymerase chain reaction</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Substrates</subject><subject>Tamoxifen</subject><subject>Tamoxifen - adverse effects</subject><subject>Tamoxifen - pharmacology</subject><subject>Tumors</subject><subject>Xenograft Model Antitumor Assays</subject><subject>Xenografts</subject><subject>Xenotransplantation</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kN1KwzAYhoMobk4PvAEJeKIH3fLTtOZw1H_mD9s8Lmmaakfb1KRFd-YleI1eidk6PRCEhPB978NLeAA4xGiIESKjhayHJMSIbYE-Rjz0_ICRbdB3GfY483EP7Fm7QAhxTuku6FFEEA0w6wMxqeT0fgzPZ9H47uvjczzDUMjGQuEOtLWunhXUGSzzqUsxDWGjoapeRCUVnItSv-eZqqBRNrfNeplXMDFK2AbK1Wz2wU4mCqsONu8APF1ezKNrb_JwdRONJ570MWceyxIkJBeJSrjwBeVMcsYklYySjBCl_IDIMxHwNCWchChNWZIlQcpSieQZlnQATrre2ujXVtkmLnMrVVGISunWxgQjQjF3mhx6_Add6NZU7neOotynzF1HnXaUNNpao7K4NnkpzDLGKF55j533eO3dsUebxjYpVfpL_oh2wKgD3vJCLf9vim-jx67yG20di6Q</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Ma, Yun</creator><creator>Bu, Deyong</creator><creator>Long, Jiang</creator><creator>Chai, Wenying</creator><creator>Dong, Jian</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3321-7404</orcidid></search><sort><creationdate>201903</creationdate><title>LncRNA DSCAM‐AS1 acts as a sponge of miR‐137 to enhance Tamoxifen resistance in breast cancer</title><author>Ma, Yun ; Bu, Deyong ; Long, Jiang ; Chai, Wenying ; Dong, Jian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4195-5fb0ac9abeb9a4a395c955c3c532f22ee462c8a69dd29270dd5bfb6d5dc0c81c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3' Untranslated regions</topic><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Cell cycle</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>DSCAM protein</topic><topic>DSCAM‐AS1</topic><topic>Epidermal growth factor</topic><topic>epidermal growth factor receptor pathway substrate 8 (EPS8)</topic><topic>Female</topic><topic>Flow cytometry</topic><topic>G1 phase</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Mice</topic><topic>MicroRNAs - genetics</topic><topic>mircoRNA‐137 (miR‐137)</topic><topic>mRNA</topic><topic>Neural cell adhesion molecule</topic><topic>Polymerase chain reaction</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Substrates</topic><topic>Tamoxifen</topic><topic>Tamoxifen - adverse effects</topic><topic>Tamoxifen - pharmacology</topic><topic>Tumors</topic><topic>Xenograft Model Antitumor Assays</topic><topic>Xenografts</topic><topic>Xenotransplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Yun</creatorcontrib><creatorcontrib>Bu, Deyong</creatorcontrib><creatorcontrib>Long, Jiang</creatorcontrib><creatorcontrib>Chai, Wenying</creatorcontrib><creatorcontrib>Dong, Jian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Yun</au><au>Bu, Deyong</au><au>Long, Jiang</au><au>Chai, Wenying</au><au>Dong, Jian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>LncRNA DSCAM‐AS1 acts as a sponge of miR‐137 to enhance Tamoxifen resistance in breast cancer</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-03</date><risdate>2019</risdate><volume>234</volume><issue>3</issue><spage>2880</spage><epage>2894</epage><pages>2880-2894</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Objective
To investigate the influence of long noncoding RNA (lncRNA) DSCAM‐AS1 on the propagation and apoptosis of Tamoxifen‐resistant (TR) breast cancer cells via regulation of mircoRNA (miR)‐137 and epidermal growth factor receptor pathway substrate 8 (EPS8).
Methods
Data of GSE5840 downloaded from the Gene Expression Omnibus database were utilized to screen out aberrantly expressed lncRNA and messenger RNA in breast cancer tissue samples. The expressions of DSCAM‐AS1, miR‐137, and EPS8 were determined by quantitative real time polymerase chain reaction (qRT‐PCR). Cell lines were screened by half maximal inhibitory concentration (IC
50). 3‐(4,5‐dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2‐H‐tetrazolium bromide (MTT) assay and the flow cytometry assay were used to detect cell proliferation, apoptosis, and cell cycle. The relationship among DSCAM‐AS1, miR‐137, and EPS8 was studied by miRcode, TargetScan, and Pearson correlation coefficient. A xenograft mouse model experiment was performed to demonstrate the effect of DSCAM‐AS1 and EPS8 on tumor growth in vivo.
Results
LncRNA DSCAM‐AS1 and EPS8 were significantly upregulated, whereas miR‐137 was downregulated in TR tissues. DSCAM‐AS1 could promote the Tamoxifen resistance of breast cancer, and it was negatively correlated with miR‐137, whereas positively correlated with the expression of EPS8 in TR breast cancer tissues. Furthermore, miR‐137 could inhibit tumor development and arrest cell cycle at the G0/G1 phase by targeting the 3′‐UTR of EPS8. DSCAM‐AS1 targeted miR‐137 and EPS8 to promote propagation of TR breast cancer cells and inhibit cell apoptosis.
Conclusion
LncRNA DSCAM‐AS1 acts as a competing endogenous RNA of miR‐137 and regulates EPS8 to promote cell reproduction and suppresses cell apoptosis in TR breast cancer.
1.DSCAM‐AS1 could modulate the expression of epidermal growth factor receptor pathway substrate 8 (EPS8) through mircoRNA (miR)‐137 in breast cancer cells, promote Tamoxifen resistance, propagation, and metastasis of cells in breast cancer, and inhibit cell apoptosis.
2.The DSCAM‐AS1/miR‐137/EPS8 axis may provide new therapeutic targets for Tamoxifen‐resistant breast cancer.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30203615</pmid><doi>10.1002/jcp.27105</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-3321-7404</orcidid></addata></record> |
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| subjects | 3' Untranslated regions Adaptor Proteins, Signal Transducing - genetics Animals Apoptosis Apoptosis - drug effects Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell cycle Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Correlation coefficient Correlation coefficients Drug Resistance, Neoplasm - genetics DSCAM protein DSCAM‐AS1 Epidermal growth factor epidermal growth factor receptor pathway substrate 8 (EPS8) Female Flow cytometry G1 phase Gene expression Gene Expression Regulation, Neoplastic - drug effects Growth factors Humans Mice MicroRNAs - genetics mircoRNA‐137 (miR‐137) mRNA Neural cell adhesion molecule Polymerase chain reaction Ribonucleic acid RNA RNA, Long Noncoding - genetics Substrates Tamoxifen Tamoxifen - adverse effects Tamoxifen - pharmacology Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation |
| title | LncRNA DSCAM‐AS1 acts as a sponge of miR‐137 to enhance Tamoxifen resistance in breast cancer |
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