Low-potency glucocorticoid hydrocortisone has similar neurotoxic effects as high-potency glucocorticoid dexamethasone on neurons in the immature chicken cerebellum

Abstract High-potency glucocorticoids (GC) are used in the prophylaxis and treatment of neonatal bronchopulmonal dysplasia, but there is concern about side effects on the developing brain. Recently, the low-potency GC hydrocortisone (HC) has been suggested as an alternative to high-potency GC. We co...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 2008-10, Vol.1236, p.39-48
Hauptverfasser:	Aden, Petra, Goverud, Ingeborg, Liestøl, Knut, Løberg, Else Marit, Paulsen, Ragnhild E, Mæhlen, Jan, Lømo, Jon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Biological and medical sciences Caspase 3 - metabolism Caspase Inhibitors Cells, Cultured Cerebellar development Cerebellum - cytology Chick Embryo - drug effects Development. Senescence. Regeneration. Transplantation Dexamethasone - toxicity Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Glucocorticoids Glucocorticoids - toxicity Hydrocortisone - toxicity Indoles Neurology Neurons - drug effects Neurotoxicity Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Transcription, Genetic - drug effects Transfection Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!