Deep-vein thrombosis in Europe — Burden of illness in relationship to healthcare resource utilization and return to work
Deep-vein thrombosis (DVT) forms a major healthcare burden in Europe, but exact estimates concerning the economic burden on society are lacking. This study reports results from the PREFER in VTE study concerning resource utilization and absence from work in DVT patients. The PREFER in VTE registry w...
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| Veröffentlicht in: | Thrombosis research 2018-10, Vol.170, p.165-174 |
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| creator | Chuang, L.H. van Hout, B. Cohen, A.T. Gumbs, P.D. Kroep, S. Bauersachs, R. Gitt, A. Monreal, M. Willich, S.N. Agnelli, G. |
| description | Deep-vein thrombosis (DVT) forms a major healthcare burden in Europe, but exact estimates concerning the economic burden on society are lacking. This study reports results from the PREFER in VTE study concerning resource utilization and absence from work in DVT patients.
The PREFER in VTE registry was a prospective, observational, multicenter study carried out in Europe (France, Italy, Spain, the UK, and DACH [Germany, Switzerland and Austria]), designed to provide data concerning treatment patterns, resource utilization, mortality and quality of life. Patients with a first-time and/or recurrent DVT, were recruited and followed for 12 months. Data about resource utilization concerns resource utilization related to DVT. Specifically, treatment pattern, re-hospitalization rate, length of hospital stay, ambulatory/office visit, and proportion of patients returning to work, were analyzed and presented. Subgroup analysis by country and active cancer were also conducted. The length of hospital stay was analyzed as a function of demographics, previous events and co-morbidities using zero-inflated binomial negative regression. Similarly, time until return to work was analyzed using Cox regression.
A total of 2056 patients with DVT were recruited, with an average age of 60 years. Patients with active cancer were mostly treated with heparin (83.9%), while patients without active cancer were treated with combinations of heparin, VKA and DOACs. DOACs were less often used in Spain and Italy (30% did not return to work within the year.
Medical treatment of DVT differed between patients with active cancer and those without. Post-VTE or VTE-related resource utilization differs remarkably between countries. Work-loss seems high, but questions may be raised concerning the causality due to the presence of co-morbidities.
•Medication use significantly differed for active cancer patients.•Post-VTE re-hospitalization rate and length of stay varied between countries.•30% |
| doi_str_mv | 10.1016/j.thromres.2018.08.001 |
| format | Article |
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The PREFER in VTE registry was a prospective, observational, multicenter study carried out in Europe (France, Italy, Spain, the UK, and DACH [Germany, Switzerland and Austria]), designed to provide data concerning treatment patterns, resource utilization, mortality and quality of life. Patients with a first-time and/or recurrent DVT, were recruited and followed for 12 months. Data about resource utilization concerns resource utilization related to DVT. Specifically, treatment pattern, re-hospitalization rate, length of hospital stay, ambulatory/office visit, and proportion of patients returning to work, were analyzed and presented. Subgroup analysis by country and active cancer were also conducted. The length of hospital stay was analyzed as a function of demographics, previous events and co-morbidities using zero-inflated binomial negative regression. Similarly, time until return to work was analyzed using Cox regression.
A total of 2056 patients with DVT were recruited, with an average age of 60 years. Patients with active cancer were mostly treated with heparin (83.9%), while patients without active cancer were treated with combinations of heparin, VKA and DOACs. DOACs were less often used in Spain and Italy (<7.0%). Following the management of their initial DVT 20.5% of the patients with and 12.2% of patients without active cancer (n = 88; n = 1462) were hospitalized for on average 8.2 and 10.1 days, respectively. The hospitalization-rate was highest in Italy (16.7%) and lowest in France (7.7%). Furthermore, the average length of stay was highest in Italy (16.6 days) and lowest in DACH (5.2 days). Physician visits were highest in DACH (9.3), lowest in the UK (2.6). Of those working, 50% returned to work at 1 month; >30% did not return to work within the year.
Medical treatment of DVT differed between patients with active cancer and those without. Post-VTE or VTE-related resource utilization differs remarkably between countries. Work-loss seems high, but questions may be raised concerning the causality due to the presence of co-morbidities.
•Medication use significantly differed for active cancer patients.•Post-VTE re-hospitalization rate and length of stay varied between countries.•30% of employed patients had still not returned to work after one year.•Active cancer plays a significant role in healthcare utilization and return to work.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2018.08.001</identifier><identifier>PMID: 30196194</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Aged ; Burden of illness ; Deep-vein thrombosis ; Europe ; Female ; Healthcare resource utilization ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality of Life - psychology ; Return to work ; Return to Work - psychology ; Venous Thrombosis - epidemiology ; Work-loss</subject><ispartof>Thrombosis research, 2018-10, Vol.170, p.165-174</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-5bdc59203f068e1df5f207f1c0df35605b5385646fc65b661ec2d97b79c363243</citedby><cites>FETCH-LOGICAL-c416t-5bdc59203f068e1df5f207f1c0df35605b5385646fc65b661ec2d97b79c363243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.thromres.2018.08.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30196194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chuang, L.H.</creatorcontrib><creatorcontrib>van Hout, B.</creatorcontrib><creatorcontrib>Cohen, A.T.</creatorcontrib><creatorcontrib>Gumbs, P.D.</creatorcontrib><creatorcontrib>Kroep, S.</creatorcontrib><creatorcontrib>Bauersachs, R.</creatorcontrib><creatorcontrib>Gitt, A.</creatorcontrib><creatorcontrib>Monreal, M.</creatorcontrib><creatorcontrib>Willich, S.N.</creatorcontrib><creatorcontrib>Agnelli, G.</creatorcontrib><title>Deep-vein thrombosis in Europe — Burden of illness in relationship to healthcare resource utilization and return to work</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Deep-vein thrombosis (DVT) forms a major healthcare burden in Europe, but exact estimates concerning the economic burden on society are lacking. This study reports results from the PREFER in VTE study concerning resource utilization and absence from work in DVT patients.
The PREFER in VTE registry was a prospective, observational, multicenter study carried out in Europe (France, Italy, Spain, the UK, and DACH [Germany, Switzerland and Austria]), designed to provide data concerning treatment patterns, resource utilization, mortality and quality of life. Patients with a first-time and/or recurrent DVT, were recruited and followed for 12 months. Data about resource utilization concerns resource utilization related to DVT. Specifically, treatment pattern, re-hospitalization rate, length of hospital stay, ambulatory/office visit, and proportion of patients returning to work, were analyzed and presented. Subgroup analysis by country and active cancer were also conducted. The length of hospital stay was analyzed as a function of demographics, previous events and co-morbidities using zero-inflated binomial negative regression. Similarly, time until return to work was analyzed using Cox regression.
A total of 2056 patients with DVT were recruited, with an average age of 60 years. Patients with active cancer were mostly treated with heparin (83.9%), while patients without active cancer were treated with combinations of heparin, VKA and DOACs. DOACs were less often used in Spain and Italy (<7.0%). Following the management of their initial DVT 20.5% of the patients with and 12.2% of patients without active cancer (n = 88; n = 1462) were hospitalized for on average 8.2 and 10.1 days, respectively. The hospitalization-rate was highest in Italy (16.7%) and lowest in France (7.7%). Furthermore, the average length of stay was highest in Italy (16.6 days) and lowest in DACH (5.2 days). Physician visits were highest in DACH (9.3), lowest in the UK (2.6). Of those working, 50% returned to work at 1 month; >30% did not return to work within the year.
Medical treatment of DVT differed between patients with active cancer and those without. Post-VTE or VTE-related resource utilization differs remarkably between countries. Work-loss seems high, but questions may be raised concerning the causality due to the presence of co-morbidities.
•Medication use significantly differed for active cancer patients.•Post-VTE re-hospitalization rate and length of stay varied between countries.•30% of employed patients had still not returned to work after one year.•Active cancer plays a significant role in healthcare utilization and return to work.</description><subject>Aged</subject><subject>Burden of illness</subject><subject>Deep-vein thrombosis</subject><subject>Europe</subject><subject>Female</subject><subject>Healthcare resource utilization</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Quality of Life - psychology</subject><subject>Return to work</subject><subject>Return to Work - psychology</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Work-loss</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1O3DAQx62qqGxpXwH5yCWLP2InvkH5KhJSL_RsJfZY6202DrZDVU48BE_Ik9S7C71WGsmy_r-Z0fwQOqZkSQmVp-tlXsWwiZCWjNB2SUoR-gEtaNuoitUN-4gWhNSq4m3dHqLPKa0L0FAlPqFDTqiSVNUL9HQJMFWP4Ee8G9iH5BMuv6s5hgnw6_ML_jZHCyMODvthGCHt8ghDl30Y08pPOAe8gm7IK9NFKFEKczSA5-wH_7TDcDfaEuQ5jlv6d4i_vqAD1w0Jvr69R-jn9dX9xffq7sfN7cX5XWVqKnMlemuEYoQ7Ilug1gnHSOOoIdZxIYnoBW-FrKUzUvRSUjDMqqZvlOGSs5ofoZP93CmGhxlS1hufDAxDN0KYk2ZFqGJctW1B5R41MaQUwekp-k0X_2hK9Na7Xut373rrXZNShJbG47cdc78B-6_tXXQBzvYAlEsfPUSdjIfRgPURTNY2-P_t-AszGZp_</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Chuang, L.H.</creator><creator>van Hout, B.</creator><creator>Cohen, A.T.</creator><creator>Gumbs, P.D.</creator><creator>Kroep, S.</creator><creator>Bauersachs, R.</creator><creator>Gitt, A.</creator><creator>Monreal, M.</creator><creator>Willich, S.N.</creator><creator>Agnelli, G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201810</creationdate><title>Deep-vein thrombosis in Europe — Burden of illness in relationship to healthcare resource utilization and return to work</title><author>Chuang, L.H. ; van Hout, B. ; Cohen, A.T. ; Gumbs, P.D. ; Kroep, S. ; Bauersachs, R. ; Gitt, A. ; Monreal, M. ; Willich, S.N. ; Agnelli, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-5bdc59203f068e1df5f207f1c0df35605b5385646fc65b661ec2d97b79c363243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Burden of illness</topic><topic>Deep-vein thrombosis</topic><topic>Europe</topic><topic>Female</topic><topic>Healthcare resource utilization</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Quality of Life - psychology</topic><topic>Return to work</topic><topic>Return to Work - psychology</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Work-loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chuang, L.H.</creatorcontrib><creatorcontrib>van Hout, B.</creatorcontrib><creatorcontrib>Cohen, A.T.</creatorcontrib><creatorcontrib>Gumbs, P.D.</creatorcontrib><creatorcontrib>Kroep, S.</creatorcontrib><creatorcontrib>Bauersachs, R.</creatorcontrib><creatorcontrib>Gitt, A.</creatorcontrib><creatorcontrib>Monreal, M.</creatorcontrib><creatorcontrib>Willich, S.N.</creatorcontrib><creatorcontrib>Agnelli, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chuang, L.H.</au><au>van Hout, B.</au><au>Cohen, A.T.</au><au>Gumbs, P.D.</au><au>Kroep, S.</au><au>Bauersachs, R.</au><au>Gitt, A.</au><au>Monreal, M.</au><au>Willich, S.N.</au><au>Agnelli, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deep-vein thrombosis in Europe — Burden of illness in relationship to healthcare resource utilization and return to work</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2018-10</date><risdate>2018</risdate><volume>170</volume><spage>165</spage><epage>174</epage><pages>165-174</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><abstract>Deep-vein thrombosis (DVT) forms a major healthcare burden in Europe, but exact estimates concerning the economic burden on society are lacking. This study reports results from the PREFER in VTE study concerning resource utilization and absence from work in DVT patients.
The PREFER in VTE registry was a prospective, observational, multicenter study carried out in Europe (France, Italy, Spain, the UK, and DACH [Germany, Switzerland and Austria]), designed to provide data concerning treatment patterns, resource utilization, mortality and quality of life. Patients with a first-time and/or recurrent DVT, were recruited and followed for 12 months. Data about resource utilization concerns resource utilization related to DVT. Specifically, treatment pattern, re-hospitalization rate, length of hospital stay, ambulatory/office visit, and proportion of patients returning to work, were analyzed and presented. Subgroup analysis by country and active cancer were also conducted. The length of hospital stay was analyzed as a function of demographics, previous events and co-morbidities using zero-inflated binomial negative regression. Similarly, time until return to work was analyzed using Cox regression.
A total of 2056 patients with DVT were recruited, with an average age of 60 years. Patients with active cancer were mostly treated with heparin (83.9%), while patients without active cancer were treated with combinations of heparin, VKA and DOACs. DOACs were less often used in Spain and Italy (<7.0%). Following the management of their initial DVT 20.5% of the patients with and 12.2% of patients without active cancer (n = 88; n = 1462) were hospitalized for on average 8.2 and 10.1 days, respectively. The hospitalization-rate was highest in Italy (16.7%) and lowest in France (7.7%). Furthermore, the average length of stay was highest in Italy (16.6 days) and lowest in DACH (5.2 days). Physician visits were highest in DACH (9.3), lowest in the UK (2.6). Of those working, 50% returned to work at 1 month; >30% did not return to work within the year.
Medical treatment of DVT differed between patients with active cancer and those without. Post-VTE or VTE-related resource utilization differs remarkably between countries. Work-loss seems high, but questions may be raised concerning the causality due to the presence of co-morbidities.
•Medication use significantly differed for active cancer patients.•Post-VTE re-hospitalization rate and length of stay varied between countries.•30% of employed patients had still not returned to work after one year.•Active cancer plays a significant role in healthcare utilization and return to work.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>30196194</pmid><doi>10.1016/j.thromres.2018.08.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Burden of illness Deep-vein thrombosis Europe Female Healthcare resource utilization Humans Male Middle Aged Prospective Studies Quality of Life - psychology Return to work Return to Work - psychology Venous Thrombosis - epidemiology Work-loss |
| title | Deep-vein thrombosis in Europe — Burden of illness in relationship to healthcare resource utilization and return to work |
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