Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin
[Display omitted] Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (vi...
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| Veröffentlicht in: | Pharmacological research 2018-10, Vol.136, p.172-180 |
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| creator | Shi, Zhe Chen, Ying Lu, Cong Dong, Li-ming Lv, Jing-wei Tuo, Qin-hui Qin, Li Cheng, Shao-wu Bu, Lan-lan Lin, Na Zhu, Xiao-xin Liao, Duan-fang Liu, Xin-min |
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Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. However, the precise mechanism of their anti-neuroinflammatory effects and potential neurotoxicity, which hindered further progress in these aspects, remains unclear. We suggest that further understanding of the PK/PD properties and structure-action relationship of atemisinin and its derivatives will facilitate the development of new therapeutics with better curative effects and safety. |
| doi_str_mv | 10.1016/j.phrs.2018.09.002 |
| format | Article |
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Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. However, the precise mechanism of their anti-neuroinflammatory effects and potential neurotoxicity, which hindered further progress in these aspects, remains unclear. We suggest that further understanding of the PK/PD properties and structure-action relationship of atemisinin and its derivatives will facilitate the development of new therapeutics with better curative effects and safety.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1016/j.phrs.2018.09.002</identifier><identifier>PMID: 30196102</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Artemisinins ; CNS disease ; Endoperoxide bridge ; Neuroinflammtion ; Neurotoxicity</subject><ispartof>Pharmacological research, 2018-10, Vol.136, p.172-180</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-728d3d605d9b98391a8b2e0aa2e67221e308a71d91f45d89262f0f8a685b97413</citedby><cites>FETCH-LOGICAL-c356t-728d3d605d9b98391a8b2e0aa2e67221e308a71d91f45d89262f0f8a685b97413</cites><orcidid>0000-0001-6452-4645</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.phrs.2018.09.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30196102$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Zhe</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Lu, Cong</creatorcontrib><creatorcontrib>Dong, Li-ming</creatorcontrib><creatorcontrib>Lv, Jing-wei</creatorcontrib><creatorcontrib>Tuo, Qin-hui</creatorcontrib><creatorcontrib>Qin, Li</creatorcontrib><creatorcontrib>Cheng, Shao-wu</creatorcontrib><creatorcontrib>Bu, Lan-lan</creatorcontrib><creatorcontrib>Lin, Na</creatorcontrib><creatorcontrib>Zhu, Xiao-xin</creatorcontrib><creatorcontrib>Liao, Duan-fang</creatorcontrib><creatorcontrib>Liu, Xin-min</creatorcontrib><title>Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>[Display omitted]
Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. However, the precise mechanism of their anti-neuroinflammatory effects and potential neurotoxicity, which hindered further progress in these aspects, remains unclear. We suggest that further understanding of the PK/PD properties and structure-action relationship of atemisinin and its derivatives will facilitate the development of new therapeutics with better curative effects and safety.</description><subject>Artemisinins</subject><subject>CNS disease</subject><subject>Endoperoxide bridge</subject><subject>Neuroinflammtion</subject><subject>Neurotoxicity</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1rHDEMhk1paT7_QA9ljj1kprJn12tDLiXkCwKBkpyNdqxJvMzYU9sTyL-vp5v0mIOQhF69SA9j3zg0HLj8uWum55gaAVw1oBsA8YkdctCy5lzJz0u9amspuTpgRyntAECvOHxlBy1wLTmIQ0a_KYXhxfmnytMcg_P9gOOI2QV_VuVnWiLiRHN2XTWFTD47HKrQ_xti6eoRB4wOKxvnp6rH0Q2vyxxjptEl550_YV96HBKdvuVj9nh1-XBxU9_dX99e_Lqru3Ytc70RyrZWwtrqrVat5qi2ggBRkNwIwakFhRtuNe9Xa6u0kKKHXqFU663erHh7zH7sfacY_syUsikHdDQM6CnMyYjCTYu2WBep2Eu7GFKK1JspuhHjq-FgFrxmZxa8ZsFrQJuCtyx9f_OftyPZ_yvvPIvgfC-g8uWLo2hS58h3ZF2kLhsb3Ef-fwEYcoyW</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Shi, Zhe</creator><creator>Chen, Ying</creator><creator>Lu, Cong</creator><creator>Dong, Li-ming</creator><creator>Lv, Jing-wei</creator><creator>Tuo, Qin-hui</creator><creator>Qin, Li</creator><creator>Cheng, Shao-wu</creator><creator>Bu, Lan-lan</creator><creator>Lin, Na</creator><creator>Zhu, Xiao-xin</creator><creator>Liao, Duan-fang</creator><creator>Liu, Xin-min</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6452-4645</orcidid></search><sort><creationdate>201810</creationdate><title>Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin</title><author>Shi, Zhe ; Chen, Ying ; Lu, Cong ; Dong, Li-ming ; Lv, Jing-wei ; Tuo, Qin-hui ; Qin, Li ; Cheng, Shao-wu ; Bu, Lan-lan ; Lin, Na ; Zhu, Xiao-xin ; Liao, Duan-fang ; Liu, Xin-min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-728d3d605d9b98391a8b2e0aa2e67221e308a71d91f45d89262f0f8a685b97413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Artemisinins</topic><topic>CNS disease</topic><topic>Endoperoxide bridge</topic><topic>Neuroinflammtion</topic><topic>Neurotoxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Zhe</creatorcontrib><creatorcontrib>Chen, Ying</creatorcontrib><creatorcontrib>Lu, Cong</creatorcontrib><creatorcontrib>Dong, Li-ming</creatorcontrib><creatorcontrib>Lv, Jing-wei</creatorcontrib><creatorcontrib>Tuo, Qin-hui</creatorcontrib><creatorcontrib>Qin, Li</creatorcontrib><creatorcontrib>Cheng, Shao-wu</creatorcontrib><creatorcontrib>Bu, Lan-lan</creatorcontrib><creatorcontrib>Lin, Na</creatorcontrib><creatorcontrib>Zhu, Xiao-xin</creatorcontrib><creatorcontrib>Liao, Duan-fang</creatorcontrib><creatorcontrib>Liu, Xin-min</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Zhe</au><au>Chen, Ying</au><au>Lu, Cong</au><au>Dong, Li-ming</au><au>Lv, Jing-wei</au><au>Tuo, Qin-hui</au><au>Qin, Li</au><au>Cheng, Shao-wu</au><au>Bu, Lan-lan</au><au>Lin, Na</au><au>Zhu, Xiao-xin</au><au>Liao, Duan-fang</au><au>Liu, Xin-min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>2018-10</date><risdate>2018</risdate><volume>136</volume><spage>172</spage><epage>180</epage><pages>172-180</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>[Display omitted]
Artemisinin (Qinghaosu) and its semi-synthetic derivatives have been demonstrated to alleviate neuroinflammatory response in the central nerve system (CNS). In this review, we summarized that artemisinins are capable to treat neuroinflammtion-related CNS diseases in both direct (via regulating inflammatory process in the CNS, exerting anti-oxidative stress and neuroprotective effect, and preventing Aβ accumulation) and indirect (via maintaining BBB integrity, suppressing systemic inflammation and alleviating intestinal inflammtion) manner. However, the precise mechanism of their anti-neuroinflammatory effects and potential neurotoxicity, which hindered further progress in these aspects, remains unclear. We suggest that further understanding of the PK/PD properties and structure-action relationship of atemisinin and its derivatives will facilitate the development of new therapeutics with better curative effects and safety.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30196102</pmid><doi>10.1016/j.phrs.2018.09.002</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6452-4645</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Artemisinins CNS disease Endoperoxide bridge Neuroinflammtion Neurotoxicity |
| title | Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin |
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