Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009–2017) in a university Greek hospital
Purpose The aim of the present study was to analyze candidaemia’s epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period. Methods All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017...
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| Veröffentlicht in: | Infection 2019-04, Vol.47 (2), p.209-216 |
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| creator | Papadimitriou-Olivgeris, Matthaios Spiliopoulou, Anastasia Kolonitsiou, Fevronia Bartzavali, Christina Lambropoulou, Anastasia Xaplanteri, Panagiota Anastassiou, Evangelos D. Marangos, Markos Spiliopoulou, Iris Christofidou, Myrto |
| description | Purpose
The aim of the present study was to analyze candidaemia’s epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period.
Methods
All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017 were included. Candida isolates were identified using the germ tube test, API 20C AUX System, and/or Vitek-2 YST card. Antifungal susceptibility was determined by the gradient method according to CLSI.
Results
During the study period, 505 episodes of candidaemia were observed with an overall incidence of 1.5 episodes per 1000 hospital admissions (1.1 episodes in 2009 to 1.9 in 2017:
P
0.038,
r
0.694).
C. albicans
was the leading cause (200 cases; 39.6%), followed by
C. parapsilosis
(185; 36.6%),
C. glabrata
(56; 11.1%),
C. tropicalis
(50; 9.9%),
C. krusei
(8; 0.2%),
C. lusitaniae
(5; |
| doi_str_mv | 10.1007/s15010-018-1217-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2101923556</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2100939090</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-2bc489af23f2930de1a8cdaea2cbcdd56b33bbb23f1430b6f225ed91f403dbcf3</originalsourceid><addsrcrecordid>eNp1kc9qFTEUxoNY7LX6AG4k4KYuUk-S-ZelXLQWCt3oesjf29SZZExmCnfnO7j34XwSM0xVELrKgfP7vhy-D6FXFC4oQPsu0xooEKAdoYy2hD1BO1pxQUC0_CnaAQcgHWXNKXqe8x0A1KJqn6FTDlQ0vK536OdV0MnK7MMB-6C9sUFbHB3WMhhvpB29xGXE-da7eaXsVKDRxyEejkWCnbyPaVXsNwUOMRA5KF8c8gpILMjRyoQnm3w0-JwBiF_ffzCg7dsNWIK_tyn7-Ygvk7Vf8W3Mk5_l8AKdODlk-_LhPUNfPn74vP9Erm8ur_bvr4mueDcTpnTVCekYd0xwMJbKTpfjJdNKG1M3inOlVFmXeEA1jrHaGkFdBdwo7fgZOt98pxS_LTbP_eiztsMgg41L7hktibGSWFPQN_-hd3FJoVy3UiC4AAGFohulU8w5WddPyY8yHXsK_Vpev5XXl_L6tbyeFc3rB-dFjdb8VfxpqwBsA3JZhYNN_75-3PU3dTmlzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2100939090</pqid></control><display><type>article</type><title>Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009–2017) in a university Greek hospital</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Papadimitriou-Olivgeris, Matthaios ; Spiliopoulou, Anastasia ; Kolonitsiou, Fevronia ; Bartzavali, Christina ; Lambropoulou, Anastasia ; Xaplanteri, Panagiota ; Anastassiou, Evangelos D. ; Marangos, Markos ; Spiliopoulou, Iris ; Christofidou, Myrto</creator><creatorcontrib>Papadimitriou-Olivgeris, Matthaios ; Spiliopoulou, Anastasia ; Kolonitsiou, Fevronia ; Bartzavali, Christina ; Lambropoulou, Anastasia ; Xaplanteri, Panagiota ; Anastassiou, Evangelos D. ; Marangos, Markos ; Spiliopoulou, Iris ; Christofidou, Myrto</creatorcontrib><description>Purpose
The aim of the present study was to analyze candidaemia’s epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period.
Methods
All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017 were included. Candida isolates were identified using the germ tube test, API 20C AUX System, and/or Vitek-2 YST card. Antifungal susceptibility was determined by the gradient method according to CLSI.
Results
During the study period, 505 episodes of candidaemia were observed with an overall incidence of 1.5 episodes per 1000 hospital admissions (1.1 episodes in 2009 to 1.9 in 2017:
P
0.038,
r
0.694).
C. albicans
was the leading cause (200 cases; 39.6%), followed by
C. parapsilosis
(185; 36.6%),
C. glabrata
(56; 11.1%),
C. tropicalis
(50; 9.9%),
C. krusei
(8; 0.2%),
C. lusitaniae
(5; < 0.1%), and
C. guilliermondii
(1; < 0.1%). Overall resistance to fluconazole, voriconazole, anidulafungin, caspofungin, and micafungin (according to CLSI) were 11.6%, 4.1%, 2.0%, 6.0%, and 0.8%, respectively. The overall consumption of antifungal drugs was stable, with a significant reduction of fluconazole’s use in favor of echinocandins.
Conclusions
An increase in the incidence of candidaemia and a predominance of
Candida
non-
albicans
due to decreasing use of fluconazole in favor of more potent antifungals, such as echinocandins, are reported in this study.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-018-1217-2</identifier><identifier>PMID: 30196355</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antifungal agents ; Antifungal Agents - therapeutic use ; Candida ; Candida - isolation & purification ; Candidemia ; Candidemia - epidemiology ; Candidemia - microbiology ; Caspofungin ; Drug Resistance, Fungal ; Echinocandins ; Epidemiology ; Family Medicine ; Female ; Fluconazole ; Fungicides ; General Practice ; Greece - epidemiology ; Hospitals, University - statistics & numerical data ; Humans ; Incidence ; Infectious Diseases ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Micafungin ; Middle Aged ; Original Paper ; Species Specificity ; Voriconazole</subject><ispartof>Infection, 2019-04, Vol.47 (2), p.209-216</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Infection is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-2bc489af23f2930de1a8cdaea2cbcdd56b33bbb23f1430b6f225ed91f403dbcf3</citedby><cites>FETCH-LOGICAL-c438t-2bc489af23f2930de1a8cdaea2cbcdd56b33bbb23f1430b6f225ed91f403dbcf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-018-1217-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-018-1217-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30196355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papadimitriou-Olivgeris, Matthaios</creatorcontrib><creatorcontrib>Spiliopoulou, Anastasia</creatorcontrib><creatorcontrib>Kolonitsiou, Fevronia</creatorcontrib><creatorcontrib>Bartzavali, Christina</creatorcontrib><creatorcontrib>Lambropoulou, Anastasia</creatorcontrib><creatorcontrib>Xaplanteri, Panagiota</creatorcontrib><creatorcontrib>Anastassiou, Evangelos D.</creatorcontrib><creatorcontrib>Marangos, Markos</creatorcontrib><creatorcontrib>Spiliopoulou, Iris</creatorcontrib><creatorcontrib>Christofidou, Myrto</creatorcontrib><title>Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009–2017) in a university Greek hospital</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Purpose
The aim of the present study was to analyze candidaemia’s epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period.
Methods
All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017 were included. Candida isolates were identified using the germ tube test, API 20C AUX System, and/or Vitek-2 YST card. Antifungal susceptibility was determined by the gradient method according to CLSI.
Results
During the study period, 505 episodes of candidaemia were observed with an overall incidence of 1.5 episodes per 1000 hospital admissions (1.1 episodes in 2009 to 1.9 in 2017:
P
0.038,
r
0.694).
C. albicans
was the leading cause (200 cases; 39.6%), followed by
C. parapsilosis
(185; 36.6%),
C. glabrata
(56; 11.1%),
C. tropicalis
(50; 9.9%),
C. krusei
(8; 0.2%),
C. lusitaniae
(5; < 0.1%), and
C. guilliermondii
(1; < 0.1%). Overall resistance to fluconazole, voriconazole, anidulafungin, caspofungin, and micafungin (according to CLSI) were 11.6%, 4.1%, 2.0%, 6.0%, and 0.8%, respectively. The overall consumption of antifungal drugs was stable, with a significant reduction of fluconazole’s use in favor of echinocandins.
Conclusions
An increase in the incidence of candidaemia and a predominance of
Candida
non-
albicans
due to decreasing use of fluconazole in favor of more potent antifungals, such as echinocandins, are reported in this study.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Candida</subject><subject>Candida - isolation & purification</subject><subject>Candidemia</subject><subject>Candidemia - epidemiology</subject><subject>Candidemia - microbiology</subject><subject>Caspofungin</subject><subject>Drug Resistance, Fungal</subject><subject>Echinocandins</subject><subject>Epidemiology</subject><subject>Family Medicine</subject><subject>Female</subject><subject>Fluconazole</subject><subject>Fungicides</subject><subject>General Practice</subject><subject>Greece - epidemiology</subject><subject>Hospitals, University - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Micafungin</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Species Specificity</subject><subject>Voriconazole</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc9qFTEUxoNY7LX6AG4k4KYuUk-S-ZelXLQWCt3oesjf29SZZExmCnfnO7j34XwSM0xVELrKgfP7vhy-D6FXFC4oQPsu0xooEKAdoYy2hD1BO1pxQUC0_CnaAQcgHWXNKXqe8x0A1KJqn6FTDlQ0vK536OdV0MnK7MMB-6C9sUFbHB3WMhhvpB29xGXE-da7eaXsVKDRxyEejkWCnbyPaVXsNwUOMRA5KF8c8gpILMjRyoQnm3w0-JwBiF_ffzCg7dsNWIK_tyn7-Ygvk7Vf8W3Mk5_l8AKdODlk-_LhPUNfPn74vP9Erm8ur_bvr4mueDcTpnTVCekYd0xwMJbKTpfjJdNKG1M3inOlVFmXeEA1jrHaGkFdBdwo7fgZOt98pxS_LTbP_eiztsMgg41L7hktibGSWFPQN_-hd3FJoVy3UiC4AAGFohulU8w5WddPyY8yHXsK_Vpev5XXl_L6tbyeFc3rB-dFjdb8VfxpqwBsA3JZhYNN_75-3PU3dTmlzw</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Papadimitriou-Olivgeris, Matthaios</creator><creator>Spiliopoulou, Anastasia</creator><creator>Kolonitsiou, Fevronia</creator><creator>Bartzavali, Christina</creator><creator>Lambropoulou, Anastasia</creator><creator>Xaplanteri, Panagiota</creator><creator>Anastassiou, Evangelos D.</creator><creator>Marangos, Markos</creator><creator>Spiliopoulou, Iris</creator><creator>Christofidou, Myrto</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009–2017) in a university Greek hospital</title><author>Papadimitriou-Olivgeris, Matthaios ; Spiliopoulou, Anastasia ; Kolonitsiou, Fevronia ; Bartzavali, Christina ; Lambropoulou, Anastasia ; Xaplanteri, Panagiota ; Anastassiou, Evangelos D. ; Marangos, Markos ; Spiliopoulou, Iris ; Christofidou, Myrto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-2bc489af23f2930de1a8cdaea2cbcdd56b33bbb23f1430b6f225ed91f403dbcf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candida</topic><topic>Candida - isolation & purification</topic><topic>Candidemia</topic><topic>Candidemia - epidemiology</topic><topic>Candidemia - microbiology</topic><topic>Caspofungin</topic><topic>Drug Resistance, Fungal</topic><topic>Echinocandins</topic><topic>Epidemiology</topic><topic>Family Medicine</topic><topic>Female</topic><topic>Fluconazole</topic><topic>Fungicides</topic><topic>General Practice</topic><topic>Greece - epidemiology</topic><topic>Hospitals, University - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Micafungin</topic><topic>Middle Aged</topic><topic>Original Paper</topic><topic>Species Specificity</topic><topic>Voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papadimitriou-Olivgeris, Matthaios</creatorcontrib><creatorcontrib>Spiliopoulou, Anastasia</creatorcontrib><creatorcontrib>Kolonitsiou, Fevronia</creatorcontrib><creatorcontrib>Bartzavali, Christina</creatorcontrib><creatorcontrib>Lambropoulou, Anastasia</creatorcontrib><creatorcontrib>Xaplanteri, Panagiota</creatorcontrib><creatorcontrib>Anastassiou, Evangelos D.</creatorcontrib><creatorcontrib>Marangos, Markos</creatorcontrib><creatorcontrib>Spiliopoulou, Iris</creatorcontrib><creatorcontrib>Christofidou, Myrto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papadimitriou-Olivgeris, Matthaios</au><au>Spiliopoulou, Anastasia</au><au>Kolonitsiou, Fevronia</au><au>Bartzavali, Christina</au><au>Lambropoulou, Anastasia</au><au>Xaplanteri, Panagiota</au><au>Anastassiou, Evangelos D.</au><au>Marangos, Markos</au><au>Spiliopoulou, Iris</au><au>Christofidou, Myrto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009–2017) in a university Greek hospital</atitle><jtitle>Infection</jtitle><stitle>Infection</stitle><addtitle>Infection</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>47</volume><issue>2</issue><spage>209</spage><epage>216</epage><pages>209-216</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>Purpose
The aim of the present study was to analyze candidaemia’s epidemiology (incidence, species distribution, and susceptibility rates) and antifungal consumption during a 9-year period.
Methods
All candidaemias recorded at The University General Hospital of Patras, Greece, between 2009 and 2017 were included. Candida isolates were identified using the germ tube test, API 20C AUX System, and/or Vitek-2 YST card. Antifungal susceptibility was determined by the gradient method according to CLSI.
Results
During the study period, 505 episodes of candidaemia were observed with an overall incidence of 1.5 episodes per 1000 hospital admissions (1.1 episodes in 2009 to 1.9 in 2017:
P
0.038,
r
0.694).
C. albicans
was the leading cause (200 cases; 39.6%), followed by
C. parapsilosis
(185; 36.6%),
C. glabrata
(56; 11.1%),
C. tropicalis
(50; 9.9%),
C. krusei
(8; 0.2%),
C. lusitaniae
(5; < 0.1%), and
C. guilliermondii
(1; < 0.1%). Overall resistance to fluconazole, voriconazole, anidulafungin, caspofungin, and micafungin (according to CLSI) were 11.6%, 4.1%, 2.0%, 6.0%, and 0.8%, respectively. The overall consumption of antifungal drugs was stable, with a significant reduction of fluconazole’s use in favor of echinocandins.
Conclusions
An increase in the incidence of candidaemia and a predominance of
Candida
non-
albicans
due to decreasing use of fluconazole in favor of more potent antifungals, such as echinocandins, are reported in this study.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30196355</pmid><doi>10.1007/s15010-018-1217-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 2019-04, Vol.47 (2), p.209-216 |
| issn | 0300-8126 1439-0973 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2101923556 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Aged, 80 and over Antifungal agents Antifungal Agents - therapeutic use Candida Candida - isolation & purification Candidemia Candidemia - epidemiology Candidemia - microbiology Caspofungin Drug Resistance, Fungal Echinocandins Epidemiology Family Medicine Female Fluconazole Fungicides General Practice Greece - epidemiology Hospitals, University - statistics & numerical data Humans Incidence Infectious Diseases Internal Medicine Male Medicine Medicine & Public Health Micafungin Middle Aged Original Paper Species Specificity Voriconazole |
| title | Increasing incidence of candidaemia and shifting epidemiology in favor of Candida non-albicans in a 9-year period (2009–2017) in a university Greek hospital |
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