Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes
Honokiol has been used in traditional medicine for the treatment of inflammatory diseases. Activation of glial cells plays an essential role in neurodegenerative disorders. In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes t...
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| Veröffentlicht in: | Journal of neuroimmunology 2018-10, Vol.323, p.78-86 |
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| container_title | Journal of neuroimmunology |
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| creator | Rickert, Uta Cossais, François Heimke, Marvin Arnold, Philipp Preuße-Prange, Andrea Wilms, Henrik Lucius, Ralph |
| description | Honokiol has been used in traditional medicine for the treatment of inflammatory diseases. Activation of glial cells plays an essential role in neurodegenerative disorders. In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes through the inhibition of pro-inflammatory mediators (iNOS, IL-6, IL-1β and TNF-α) and the simultaneous stimulation of anti-inflammatory cytokines (IL-10). Expression of KLF4 was induced in microglia and astrocytes after treatment with LPS and this response was mitigated by Honokiol. These findings extend our understanding of the anti-inflammatory properties of Honokiol on central glial cells and support its use as a therapeutic compound in neuroinflammatory disorders.
[Display omitted]
•Honokiol decreases TNF-α, IL-6 and IL-1β in LPS-activated astrocytes and microglia.•Honokiol stimulates IL-10 expression in LPS-activated astrocytes and microglia.•KLF4 is induced by LPS in microglia and astrocytes.•Honokiol downregulates KLF4 in LPS-activated microglia. |
| doi_str_mv | 10.1016/j.jneuroim.2018.07.013 |
| format | Article |
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[Display omitted]
•Honokiol decreases TNF-α, IL-6 and IL-1β in LPS-activated astrocytes and microglia.•Honokiol stimulates IL-10 expression in LPS-activated astrocytes and microglia.•KLF4 is induced by LPS in microglia and astrocytes.•Honokiol downregulates KLF4 in LPS-activated microglia.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2018.07.013</identifier><identifier>PMID: 30196838</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Astrocytes ; Honokiol ; IL-10 ; IL-1β ; KLF4 ; Microglia ; Neuroinflammation</subject><ispartof>Journal of neuroimmunology, 2018-10, Vol.323, p.78-86</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-1131d7b43de2447304ed8ce33b39cbb5b7d7e54591c84369e6a70b5b70af63fc3</citedby><cites>FETCH-LOGICAL-c368t-1131d7b43de2447304ed8ce33b39cbb5b7d7e54591c84369e6a70b5b70af63fc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2018.07.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30196838$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rickert, Uta</creatorcontrib><creatorcontrib>Cossais, François</creatorcontrib><creatorcontrib>Heimke, Marvin</creatorcontrib><creatorcontrib>Arnold, Philipp</creatorcontrib><creatorcontrib>Preuße-Prange, Andrea</creatorcontrib><creatorcontrib>Wilms, Henrik</creatorcontrib><creatorcontrib>Lucius, Ralph</creatorcontrib><title>Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Honokiol has been used in traditional medicine for the treatment of inflammatory diseases. Activation of glial cells plays an essential role in neurodegenerative disorders. In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes through the inhibition of pro-inflammatory mediators (iNOS, IL-6, IL-1β and TNF-α) and the simultaneous stimulation of anti-inflammatory cytokines (IL-10). Expression of KLF4 was induced in microglia and astrocytes after treatment with LPS and this response was mitigated by Honokiol. These findings extend our understanding of the anti-inflammatory properties of Honokiol on central glial cells and support its use as a therapeutic compound in neuroinflammatory disorders.
[Display omitted]
•Honokiol decreases TNF-α, IL-6 and IL-1β in LPS-activated astrocytes and microglia.•Honokiol stimulates IL-10 expression in LPS-activated astrocytes and microglia.•KLF4 is induced by LPS in microglia and astrocytes.•Honokiol downregulates KLF4 in LPS-activated microglia.</description><subject>Astrocytes</subject><subject>Honokiol</subject><subject>IL-10</subject><subject>IL-1β</subject><subject>KLF4</subject><subject>Microglia</subject><subject>Neuroinflammation</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkE9LwzAYh4Mobk6_wujRS2vStE16cwx1wsCLeg1p8lYy22Ym6WDf3oxtXj298PK8f34PQnOCM4JJ9bDJNgOMzpo-yzHhGWYZJvQCTQlnecqLnFyiaQTLtGQ5n6Ab7zcYk5IW9TWaUEzqilM-RZ-LIZjUDG0n-14G6_bJ1tktuGDAJ7ZNVnaw38Z2iRkSqYLZyQA6MqaXke2NcvarMzKRg06kD86qfQB_i65a2Xm4O9UZ-nh-el-u0vXby-tysU4VrXhICaFEs6agGvKiYBQXoLkCShtaq6YpG6YZlEVZE8ULWtVQSYYPbSzbiraKztD9cW98-mcEH0RvvIKukwPY0Ys8yqoJr3Ae0eqIxo-9d9CKUwhBsDg4FRtxdioOTgVmIjqNg_PTjbHpQf-NnSVG4PEIQEy6M-CEVwYGBdo4UEFoa_678Qs14I0r</recordid><startdate>20181015</startdate><enddate>20181015</enddate><creator>Rickert, Uta</creator><creator>Cossais, François</creator><creator>Heimke, Marvin</creator><creator>Arnold, Philipp</creator><creator>Preuße-Prange, Andrea</creator><creator>Wilms, Henrik</creator><creator>Lucius, Ralph</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181015</creationdate><title>Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes</title><author>Rickert, Uta ; Cossais, François ; Heimke, Marvin ; Arnold, Philipp ; Preuße-Prange, Andrea ; Wilms, Henrik ; Lucius, Ralph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1131d7b43de2447304ed8ce33b39cbb5b7d7e54591c84369e6a70b5b70af63fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Astrocytes</topic><topic>Honokiol</topic><topic>IL-10</topic><topic>IL-1β</topic><topic>KLF4</topic><topic>Microglia</topic><topic>Neuroinflammation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rickert, Uta</creatorcontrib><creatorcontrib>Cossais, François</creatorcontrib><creatorcontrib>Heimke, Marvin</creatorcontrib><creatorcontrib>Arnold, Philipp</creatorcontrib><creatorcontrib>Preuße-Prange, Andrea</creatorcontrib><creatorcontrib>Wilms, Henrik</creatorcontrib><creatorcontrib>Lucius, Ralph</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rickert, Uta</au><au>Cossais, François</au><au>Heimke, Marvin</au><au>Arnold, Philipp</au><au>Preuße-Prange, Andrea</au><au>Wilms, Henrik</au><au>Lucius, Ralph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2018-10-15</date><risdate>2018</risdate><volume>323</volume><spage>78</spage><epage>86</epage><pages>78-86</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Honokiol has been used in traditional medicine for the treatment of inflammatory diseases. Activation of glial cells plays an essential role in neurodegenerative disorders. In this study, we show that Honokiol reduces the inflammatory response to LPS of primary cultures of microglia and astrocytes through the inhibition of pro-inflammatory mediators (iNOS, IL-6, IL-1β and TNF-α) and the simultaneous stimulation of anti-inflammatory cytokines (IL-10). Expression of KLF4 was induced in microglia and astrocytes after treatment with LPS and this response was mitigated by Honokiol. These findings extend our understanding of the anti-inflammatory properties of Honokiol on central glial cells and support its use as a therapeutic compound in neuroinflammatory disorders.
[Display omitted]
•Honokiol decreases TNF-α, IL-6 and IL-1β in LPS-activated astrocytes and microglia.•Honokiol stimulates IL-10 expression in LPS-activated astrocytes and microglia.•KLF4 is induced by LPS in microglia and astrocytes.•Honokiol downregulates KLF4 in LPS-activated microglia.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30196838</pmid><doi>10.1016/j.jneuroim.2018.07.013</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of neuroimmunology, 2018-10, Vol.323, p.78-86 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Astrocytes Honokiol IL-10 IL-1β KLF4 Microglia Neuroinflammation |
| title | Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes |
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