Construction of Artificial TNF-Binding Proteins Based on the 10th Human Fibronectin Type III Domain Using Bacterial Display

Construction of antibody mimetics on the base of alternative scaffold proteins is a promising strategy for obtaining new products for medicine and biotechnology. The aim of our work was to optimize the cell display system for the 10th human fibronectin type III domain ( 10 Fn3) scaffold protein base...

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Veröffentlicht in:	Biochemistry (Moscow) 2018-06, Vol.83 (6), p.708-716
Hauptverfasser:	Shingarova, L. N., Petrovskaya, L. E., Zlobinov, A. V., Gapizov, S. Sh, Kryukova, E. A., Birikh, K. R., Boldyreva, E. F., Yakimov, S. A., Dolgikh, D. A., Kirpichnikov, M. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Binding Binding proteins Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Biotechnology Cloning Combinatorial analysis Display devices E coli Efficiency Fibronectin Gene amplification Health aspects Life Sciences Microbiology Proteins Scaffolds TNF inhibitors Tumor necrosis factor Tumor necrosis factor-TNF
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