Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study
The burden of Crohn’s disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world. To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years. We retrospectively evaluated the prevalen...
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| Veröffentlicht in: | Digestive and liver disease 2019-02, Vol.51 (2), p.218-225 |
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| creator | Piscaglia, Anna Chiara Lopetuso, Loris Riccardo Laterza, Lucrezia Gerardi, Viviana Sacchini, Elena Leoncini, Emanuele Boccia, Stefania Stefanelli, Maria Loredana Gasbarrini, Antonio Armuzzi, Alessandro |
| description | The burden of Crohn’s disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world.
To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years.
We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources.
Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95% CI: 1.5–10.6) in 1980–1984 to 12.4 (95% CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95% CI: 0.2–6.6) in 1980–1984 to 17.9 (95% CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed.
This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas. |
| doi_str_mv | 10.1016/j.dld.2018.08.016 |
| format | Article |
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To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years.
We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources.
Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95% CI: 1.5–10.6) in 1980–1984 to 12.4 (95% CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95% CI: 0.2–6.6) in 1980–1984 to 17.9 (95% CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed.
This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2018.08.016</identifier><identifier>PMID: 30197187</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Crohn’s disease ; Incidence ; Prevalence ; Ulcerative colitis</subject><ispartof>Digestive and liver disease, 2019-02, Vol.51 (2), p.218-225</ispartof><rights>2018 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright © 2018 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-22caa156ccb0f2e33506126b69fdbda31121bdcc007e4708282ae4a3bb2366063</citedby><cites>FETCH-LOGICAL-c353t-22caa156ccb0f2e33506126b69fdbda31121bdcc007e4708282ae4a3bb2366063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2018.08.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30197187$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piscaglia, Anna Chiara</creatorcontrib><creatorcontrib>Lopetuso, Loris Riccardo</creatorcontrib><creatorcontrib>Laterza, Lucrezia</creatorcontrib><creatorcontrib>Gerardi, Viviana</creatorcontrib><creatorcontrib>Sacchini, Elena</creatorcontrib><creatorcontrib>Leoncini, Emanuele</creatorcontrib><creatorcontrib>Boccia, Stefania</creatorcontrib><creatorcontrib>Stefanelli, Maria Loredana</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><creatorcontrib>Armuzzi, Alessandro</creatorcontrib><title>Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>The burden of Crohn’s disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world.
To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years.
We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources.
Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95% CI: 1.5–10.6) in 1980–1984 to 12.4 (95% CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95% CI: 0.2–6.6) in 1980–1984 to 17.9 (95% CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed.
This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas.</description><subject>Crohn’s disease</subject><subject>Incidence</subject><subject>Prevalence</subject><subject>Ulcerative colitis</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kM1u1DAURq2qiJbCA3SDvOwmg6_deBJYodEAI7WigrK2_HMDHiVxaidFs-s7sKUv1yfB0ZSKFdKVfKXv3E_yIeQU2AIYyDfbhWvdgjOoFiwPyANyDNWyKkQp-WHey5oVlSyrI_IipS1jHGTJnpMjwaBeZvKYDOvBO-x8aMP3HQ0N9X3T6q7TY4g7asJPbKnzCXXCHNHxB9IvOEym9Xamv-qeXuro-_CWXufs4e73-mpzuVlt8vrrn_jh7p6mcXK7l-RZo9uErx7fE_Ltw_p69am4-Pxxs3p_UVhRirHg3GoNpbTWsIajECWTwKWRdeOM0wKAg3HWMrbE8yWreMU1nmthDBdSMilOyNm-d4jhZsI0qs4ni22rewxTUjwbrAFqOaOwR20MKUVs1BB9p-NOAVOzaLVVWbSaRSuWB-ab14_1k-nQPV38NZuBd3sA8ydvPUaVrMfeovMR7ahc8P-p_wN7mY_V</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Piscaglia, Anna Chiara</creator><creator>Lopetuso, Loris Riccardo</creator><creator>Laterza, Lucrezia</creator><creator>Gerardi, Viviana</creator><creator>Sacchini, Elena</creator><creator>Leoncini, Emanuele</creator><creator>Boccia, Stefania</creator><creator>Stefanelli, Maria Loredana</creator><creator>Gasbarrini, Antonio</creator><creator>Armuzzi, Alessandro</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study</title><author>Piscaglia, Anna Chiara ; Lopetuso, Loris Riccardo ; Laterza, Lucrezia ; Gerardi, Viviana ; Sacchini, Elena ; Leoncini, Emanuele ; Boccia, Stefania ; Stefanelli, Maria Loredana ; Gasbarrini, Antonio ; Armuzzi, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-22caa156ccb0f2e33506126b69fdbda31121bdcc007e4708282ae4a3bb2366063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Crohn’s disease</topic><topic>Incidence</topic><topic>Prevalence</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piscaglia, Anna Chiara</creatorcontrib><creatorcontrib>Lopetuso, Loris Riccardo</creatorcontrib><creatorcontrib>Laterza, Lucrezia</creatorcontrib><creatorcontrib>Gerardi, Viviana</creatorcontrib><creatorcontrib>Sacchini, Elena</creatorcontrib><creatorcontrib>Leoncini, Emanuele</creatorcontrib><creatorcontrib>Boccia, Stefania</creatorcontrib><creatorcontrib>Stefanelli, Maria Loredana</creatorcontrib><creatorcontrib>Gasbarrini, Antonio</creatorcontrib><creatorcontrib>Armuzzi, Alessandro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piscaglia, Anna Chiara</au><au>Lopetuso, Loris Riccardo</au><au>Laterza, Lucrezia</au><au>Gerardi, Viviana</au><au>Sacchini, Elena</au><au>Leoncini, Emanuele</au><au>Boccia, Stefania</au><au>Stefanelli, Maria Loredana</au><au>Gasbarrini, Antonio</au><au>Armuzzi, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2019-02</date><risdate>2019</risdate><volume>51</volume><issue>2</issue><spage>218</spage><epage>225</epage><pages>218-225</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>The burden of Crohn’s disease (CD) and ulcerative colitis (UC) has never been estimated in the Republic of San Marino, the third smallest nation of the world.
To assess the occurrence and clinical features of CD and UC in San Marino during the last 35 years.
We retrospectively evaluated the prevalence, incidence, and main clinical aspects of CD and UC from 1980 to 2014, crossing data from various sources.
Prevalence rates (per 100,000) on December 31, were 241 for CD (263 in males and 220 in females) and 311 for UC (370 in males and 255 in females). The specific incidence of UC steadily increased from 4.6 (95% CI: 1.5–10.6) in 1980–1984 to 12.4 (95% CI: 7.6–19.1) in 2010–2014; CD incidence showed a higher proportional increase, from 1.8 (95% CI: 0.2–6.6) in 1980–1984 to 17.9 (95% CI: 12.0–25.7) in 2010–2014. The main clinical features of CD and UC (activity and location at diagnosis, extra-intestinal manifestations, disease progression overtime, therapies, and hospitalizations) were analyzed.
This study provides the first epidemiological report on CD and UC in San Marino, showing specific traits and overall higher prevalence and incidence rates than previously reported in neighbor Areas.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30197187</pmid><doi>10.1016/j.dld.2018.08.016</doi><tpages>8</tpages></addata></record> |
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| ispartof | Digestive and liver disease, 2019-02, Vol.51 (2), p.218-225 |
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| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Crohn’s disease Incidence Prevalence Ulcerative colitis |
| title | Epidemiology of inflammatory bowel disease in the Republic of San Marino: The “EPIMICI – San Marino” study |
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