Plant lyophilisate carrying S-HBsAg as an oral booster vaccine against HBV

•Plant lyophilisate with low-dosed S-HBsAg is effective as oral booster vaccine.•Injection priming and then 2×p.o. boosting is comparably efficient as 3×i.m. vaccination.•Oral administration of plant lyophilisate is effectual without exogenous adjuvants. A formulation of a defined antigen dosage tog...

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Veröffentlicht in:	Vaccine 2018-10, Vol.36 (41), p.6070-6076
Hauptverfasser:	Pniewski, Tomasz, Milczarek, Magdalena, Wojas-Turek, Justyna, Pajtasz-Piasecka, Elżbieta, Wietrzyk, Joanna, Czyż, Marcin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Administration, Oral Animals Antigens Bark Experiments Female Freeze Drying - methods HBV Hepatitis Hepatitis B surface antigen Hepatitis B Surface Antigens - chemistry Hepatitis B Surface Antigens - immunology Hepatitis B Surface Antigens - therapeutic use Hepatitis B Vaccines - immunology Hepatitis B Vaccines - therapeutic use Immune response Immune system Immunization Immunization, Secondary - methods Immunological tolerance Injection Injection-oral immunisation Laboratory animals Lyophilisate Mice Mice, Inbred BALB C Mucosa Oral administration Oral booster vaccine Plant extracts Plant-derived vaccine Plants Plants - chemistry Priming S-HBsAg Saponins Vaccination Vaccination - methods Vaccines
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