microRNA-340 as a modulator of RAS–RAF–MAPK signaling in melanoma

•miR-340 is a novel inhibitor of tumorigenic phenotype in melanoma cells.•miR-340 inhibits RAS–RAF–MAPK signaling pathway.•miR-340 targets multiple components of RAS–RAF–MAPK pathway. microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of me...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2014-12, Vol.563, p.118-124
Hauptverfasser:	Poenitzsch Strong, Ashley M., Setaluri, Vijayasaradhi, Spiegelman, Vladimir S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor gene expression regulation Gene Expression Regulation, Neoplastic Genes, Tumor Suppressor human cell lines Humans Invasion MAP Kinase Signaling System - genetics MAPK Melanoma Melanoma - etiology Melanoma - genetics Melanoma - metabolism microRNA MicroRNAs - genetics MicroRNAs - metabolism miR-340 mitogen-activated protein kinase Mutation pathogenesis Phenotype Proliferation RAF raf Kinases - metabolism RAS ras Proteins - metabolism Signal Transduction - genetics Tumor suppressor
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