Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity

ABSTRACT Sphingosine‐1‐phosphate (S1P) is involved in the regulation of important cellular processes, including immune‐cell trafficking and proliferation. Altered S1P signaling is strongly associated with inflammation, cancer progression, and atherosclerosis; however, the mechanisms underlying its p...

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Veröffentlicht in:	The FASEB journal 2019-02, Vol.33 (2), p.1711-1726
Hauptverfasser:	Fettel, Jasmin, Kühn, Benjamin, Guillen, Nathalie A., Sürün, Duran, Peters, Marcus, Bauer, Rebekka, Angioni, Carlo, Geisslinger, Gerd, Schnütgen, Frank, Heringdorf, Dagmar Meyer, Werz, Oliver, Meybohm, Patrick, Zacharowski, Kai, Steinhilber, Dieter, Roos, Jessica, Maier, Thorsten J.
Format:	Artikel
Sprache:	eng
Schlagworte:	calcium inactivation of 5-LO inflammation leukotriene formation lipid mediators
Online-Zugang:	Volltext
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