Habenular connectivity may predict treatment response in depressed psychiatric inpatients
•Habenula (Hb) connectivity was studied in 175 depressed psychiatric inpatients.•Hb/raphe and Hb/locus coeruleus connectivity predicted depression at discharge.•Pre-treatment Hb function may be associated with treatment resistance in depression.•Hb connectivity may be a biomarker to predict treatmen...
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| Veröffentlicht in: | Journal of affective disorders 2019-01, Vol.242, p.211-219 |
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| container_title | Journal of affective disorders |
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| creator | Gosnell, Savannah N. Curtis, Kaylah N. Velasquez, Kenia Fowler, J. Christopher Madan, Alok Goodman, Wayne Salas, Ramiro |
| description | •Habenula (Hb) connectivity was studied in 175 depressed psychiatric inpatients.•Hb/raphe and Hb/locus coeruleus connectivity predicted depression at discharge.•Pre-treatment Hb function may be associated with treatment resistance in depression.•Hb connectivity may be a biomarker to predict treatment resistance.
The habenula (Hb) is a small midbrain structure that signals negative events and may play a major role in the etiology of psychiatric disorders including depression. The lateral Hb has three major efferent connections: serotonergic raphe nuclei, noradrenergic locus coeruleus, and dopaminergic ventral tegmental area/substantia nigra compacta. We wanted to test whether Hb connectivity may be important to predict treatment outcomes in depression patients.
We studied whether habenular connectivity at admission into a psychiatric clinic can predict treatment response. We used an inpatient sample (N = 175) to assess habenular connectivity (diffusion tensor imaging and resting state functional connectivity (RSFC) between the Hb and its targets) close to admission. In addition, we obtained the Patient Health Questionnaire-depression module (PHQ-9) close to admission and at discharge. Inpatients in the study entered the clinic with at least moderately severe depression (score 15 and up). Inpatients considered treatment resistant had scores of 9 or more at discharge.
Compared to responders, treatment non-responders had lower fractional anisotropy in the right Hb afferent fibers and lower RSFC between right Hb and median raphe, but higher RSFC between left Hb and locus coeruleus. A logistic regression model was significantly different from chance, and explained 27.7% of the variance in treatment resistance (sensitivity = 75%; specificity = 71.9%).
The anatomical and functional connectivity of the Hb may be a predictor of treatment success in psychiatric populations. Limitations include the Hb small size and the limited time (5 min) of resting state data obtained. |
| doi_str_mv | 10.1016/j.jad.2018.08.026 |
| format | Article |
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The habenula (Hb) is a small midbrain structure that signals negative events and may play a major role in the etiology of psychiatric disorders including depression. The lateral Hb has three major efferent connections: serotonergic raphe nuclei, noradrenergic locus coeruleus, and dopaminergic ventral tegmental area/substantia nigra compacta. We wanted to test whether Hb connectivity may be important to predict treatment outcomes in depression patients.
We studied whether habenular connectivity at admission into a psychiatric clinic can predict treatment response. We used an inpatient sample (N = 175) to assess habenular connectivity (diffusion tensor imaging and resting state functional connectivity (RSFC) between the Hb and its targets) close to admission. In addition, we obtained the Patient Health Questionnaire-depression module (PHQ-9) close to admission and at discharge. Inpatients in the study entered the clinic with at least moderately severe depression (score 15 and up). Inpatients considered treatment resistant had scores of 9 or more at discharge.
Compared to responders, treatment non-responders had lower fractional anisotropy in the right Hb afferent fibers and lower RSFC between right Hb and median raphe, but higher RSFC between left Hb and locus coeruleus. A logistic regression model was significantly different from chance, and explained 27.7% of the variance in treatment resistance (sensitivity = 75%; specificity = 71.9%).
The anatomical and functional connectivity of the Hb may be a predictor of treatment success in psychiatric populations. Limitations include the Hb small size and the limited time (5 min) of resting state data obtained.</description><identifier>ISSN: 0165-0327</identifier><identifier>EISSN: 1573-2517</identifier><identifier>DOI: 10.1016/j.jad.2018.08.026</identifier><identifier>PMID: 30195174</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Habenula ; Locus coeruleus ; Major depression disorder ; Raphe nucleus ; Resting state functional connectivity ; Treatment outcome prediction</subject><ispartof>Journal of affective disorders, 2019-01, Vol.242, p.211-219</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-a4a41c3d4b00ade9fb9b0d3ec728878d6340206ae2f748c0ed5ffff19bcd335b3</citedby><cites>FETCH-LOGICAL-c353t-a4a41c3d4b00ade9fb9b0d3ec728878d6340206ae2f748c0ed5ffff19bcd335b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165032718312102$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30195174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gosnell, Savannah N.</creatorcontrib><creatorcontrib>Curtis, Kaylah N.</creatorcontrib><creatorcontrib>Velasquez, Kenia</creatorcontrib><creatorcontrib>Fowler, J. Christopher</creatorcontrib><creatorcontrib>Madan, Alok</creatorcontrib><creatorcontrib>Goodman, Wayne</creatorcontrib><creatorcontrib>Salas, Ramiro</creatorcontrib><title>Habenular connectivity may predict treatment response in depressed psychiatric inpatients</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>•Habenula (Hb) connectivity was studied in 175 depressed psychiatric inpatients.•Hb/raphe and Hb/locus coeruleus connectivity predicted depression at discharge.•Pre-treatment Hb function may be associated with treatment resistance in depression.•Hb connectivity may be a biomarker to predict treatment resistance.
The habenula (Hb) is a small midbrain structure that signals negative events and may play a major role in the etiology of psychiatric disorders including depression. The lateral Hb has three major efferent connections: serotonergic raphe nuclei, noradrenergic locus coeruleus, and dopaminergic ventral tegmental area/substantia nigra compacta. We wanted to test whether Hb connectivity may be important to predict treatment outcomes in depression patients.
We studied whether habenular connectivity at admission into a psychiatric clinic can predict treatment response. We used an inpatient sample (N = 175) to assess habenular connectivity (diffusion tensor imaging and resting state functional connectivity (RSFC) between the Hb and its targets) close to admission. In addition, we obtained the Patient Health Questionnaire-depression module (PHQ-9) close to admission and at discharge. Inpatients in the study entered the clinic with at least moderately severe depression (score 15 and up). Inpatients considered treatment resistant had scores of 9 or more at discharge.
Compared to responders, treatment non-responders had lower fractional anisotropy in the right Hb afferent fibers and lower RSFC between right Hb and median raphe, but higher RSFC between left Hb and locus coeruleus. A logistic regression model was significantly different from chance, and explained 27.7% of the variance in treatment resistance (sensitivity = 75%; specificity = 71.9%).
The anatomical and functional connectivity of the Hb may be a predictor of treatment success in psychiatric populations. Limitations include the Hb small size and the limited time (5 min) of resting state data obtained.</description><subject>Habenula</subject><subject>Locus coeruleus</subject><subject>Major depression disorder</subject><subject>Raphe nucleus</subject><subject>Resting state functional connectivity</subject><subject>Treatment outcome prediction</subject><issn>0165-0327</issn><issn>1573-2517</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMotlZ_gBfZo5etk2Q_8SSiVih40YOnkE1mMaX7YZIW-u-d0urRYWAO88wL8zB2zWHOgRd3q_lK27kAXs2BWhQnbMrzUqYi5-UpmxKTpyBFOWEXIawAoKhLOGcTCbwmJJuyz4VusN-stU_M0Pdootu6uEs6vUtGj9aZmESPOnbYx8RjGIc-YOL6xCLtQ0CbjGFnvpyO3hlajDo6YsMlO2v1OuDVcc7Yx_PT--MiXb69vD4-LFMjcxlTnemMG2mzBkBbrNumbsBKNKWoqrKyhcxAQKFRtGVWGUCbt1S8boyVMm_kjN0eckc_fG8wRNW5YHC91j0Om6AEqRJlITJOKD-gxg8heGzV6F2n_U5xUHujaqXIqNobVUAtCrq5OcZvmg7t38WvQgLuDwDSk1uHXgVDAgy586RT2cH9E_8Do9KI5Q</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Gosnell, Savannah N.</creator><creator>Curtis, Kaylah N.</creator><creator>Velasquez, Kenia</creator><creator>Fowler, J. Christopher</creator><creator>Madan, Alok</creator><creator>Goodman, Wayne</creator><creator>Salas, Ramiro</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Habenular connectivity may predict treatment response in depressed psychiatric inpatients</title><author>Gosnell, Savannah N. ; Curtis, Kaylah N. ; Velasquez, Kenia ; Fowler, J. Christopher ; Madan, Alok ; Goodman, Wayne ; Salas, Ramiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-a4a41c3d4b00ade9fb9b0d3ec728878d6340206ae2f748c0ed5ffff19bcd335b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Habenula</topic><topic>Locus coeruleus</topic><topic>Major depression disorder</topic><topic>Raphe nucleus</topic><topic>Resting state functional connectivity</topic><topic>Treatment outcome prediction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gosnell, Savannah N.</creatorcontrib><creatorcontrib>Curtis, Kaylah N.</creatorcontrib><creatorcontrib>Velasquez, Kenia</creatorcontrib><creatorcontrib>Fowler, J. Christopher</creatorcontrib><creatorcontrib>Madan, Alok</creatorcontrib><creatorcontrib>Goodman, Wayne</creatorcontrib><creatorcontrib>Salas, Ramiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gosnell, Savannah N.</au><au>Curtis, Kaylah N.</au><au>Velasquez, Kenia</au><au>Fowler, J. Christopher</au><au>Madan, Alok</au><au>Goodman, Wayne</au><au>Salas, Ramiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Habenular connectivity may predict treatment response in depressed psychiatric inpatients</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>242</volume><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>0165-0327</issn><eissn>1573-2517</eissn><abstract>•Habenula (Hb) connectivity was studied in 175 depressed psychiatric inpatients.•Hb/raphe and Hb/locus coeruleus connectivity predicted depression at discharge.•Pre-treatment Hb function may be associated with treatment resistance in depression.•Hb connectivity may be a biomarker to predict treatment resistance.
The habenula (Hb) is a small midbrain structure that signals negative events and may play a major role in the etiology of psychiatric disorders including depression. The lateral Hb has three major efferent connections: serotonergic raphe nuclei, noradrenergic locus coeruleus, and dopaminergic ventral tegmental area/substantia nigra compacta. We wanted to test whether Hb connectivity may be important to predict treatment outcomes in depression patients.
We studied whether habenular connectivity at admission into a psychiatric clinic can predict treatment response. We used an inpatient sample (N = 175) to assess habenular connectivity (diffusion tensor imaging and resting state functional connectivity (RSFC) between the Hb and its targets) close to admission. In addition, we obtained the Patient Health Questionnaire-depression module (PHQ-9) close to admission and at discharge. Inpatients in the study entered the clinic with at least moderately severe depression (score 15 and up). Inpatients considered treatment resistant had scores of 9 or more at discharge.
Compared to responders, treatment non-responders had lower fractional anisotropy in the right Hb afferent fibers and lower RSFC between right Hb and median raphe, but higher RSFC between left Hb and locus coeruleus. A logistic regression model was significantly different from chance, and explained 27.7% of the variance in treatment resistance (sensitivity = 75%; specificity = 71.9%).
The anatomical and functional connectivity of the Hb may be a predictor of treatment success in psychiatric populations. Limitations include the Hb small size and the limited time (5 min) of resting state data obtained.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30195174</pmid><doi>10.1016/j.jad.2018.08.026</doi><tpages>9</tpages></addata></record> |
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| subjects | Habenula Locus coeruleus Major depression disorder Raphe nucleus Resting state functional connectivity Treatment outcome prediction |
| title | Habenular connectivity may predict treatment response in depressed psychiatric inpatients |
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