The birth, evolution and death of metabolic gene clusters in fungi
Fungi contain a remarkable diversity of both primary and secondary metabolic pathways involved in ecologically specialized or accessory functions. Genes in these pathways are frequently physically linked on fungal chromosomes, forming metabolic gene clusters (MGCs). In this Review, we describe the d...
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| Veröffentlicht in: | Nature reviews. Microbiology 2018-12, Vol.16 (12), p.731-744 |
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| creator | Rokas, Antonis Wisecaver, Jennifer H. Lind, Abigail L. |
| description | Fungi contain a remarkable diversity of both primary and secondary metabolic pathways involved in ecologically specialized or accessory functions. Genes in these pathways are frequently physically linked on fungal chromosomes, forming metabolic gene clusters (MGCs). In this Review, we describe the diversity in the structure and content of fungal MGCs, their population-level and species-level variation, the evolutionary mechanisms that underlie their formation, maintenance and decay, and their ecological and evolutionary impact on fungal populations. We also discuss MGCs from other eukaryotes and the reasons for their preponderance in fungi. Improved knowledge of the evolutionary life cycle of MGCs will advance our understanding of the ecology of specialized metabolism and of the interplay between the lifestyle of an organism and genome architecture.
In this Review, Rokas, Wisecaver and Lind discuss the diversity in the structure and content of fungal metabolic gene clusters, their population-level and species-level variation, the evolutionary mechanisms that underlie their formation, maintenance and decay, and their ecological and evolutionary impact on fungal populations. |
| doi_str_mv | 10.1038/s41579-018-0075-3 |
| format | Article |
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Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rokas, Antonis</au><au>Wisecaver, Jennifer H.</au><au>Lind, Abigail L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The birth, evolution and death of metabolic gene clusters in fungi</atitle><jtitle>Nature reviews. Microbiology</jtitle><stitle>Nat Rev Microbiol</stitle><addtitle>Nat Rev Microbiol</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>16</volume><issue>12</issue><spage>731</spage><epage>744</epage><pages>731-744</pages><issn>1740-1526</issn><eissn>1740-1534</eissn><abstract>Fungi contain a remarkable diversity of both primary and secondary metabolic pathways involved in ecologically specialized or accessory functions. Genes in these pathways are frequently physically linked on fungal chromosomes, forming metabolic gene clusters (MGCs). In this Review, we describe the diversity in the structure and content of fungal MGCs, their population-level and species-level variation, the evolutionary mechanisms that underlie their formation, maintenance and decay, and their ecological and evolutionary impact on fungal populations. We also discuss MGCs from other eukaryotes and the reasons for their preponderance in fungi. Improved knowledge of the evolutionary life cycle of MGCs will advance our understanding of the ecology of specialized metabolism and of the interplay between the lifestyle of an organism and genome architecture.
In this Review, Rokas, Wisecaver and Lind discuss the diversity in the structure and content of fungal metabolic gene clusters, their population-level and species-level variation, the evolutionary mechanisms that underlie their formation, maintenance and decay, and their ecological and evolutionary impact on fungal populations.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30194403</pmid><doi>10.1038/s41579-018-0075-3</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-9579-4178</orcidid><orcidid>https://orcid.org/0000-0002-7248-6551</orcidid><orcidid>https://orcid.org/0000-0001-6843-5906</orcidid></addata></record> |
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| subjects | 38/23 631/158/855 631/181 631/326/193/2539 631/326/193/2541 Biodiversity Biological evolution Biomedical and Life Sciences Cell metabolism Chromosomes Decay Ecology Eukaryotes Evolution Evolution, Molecular Fungi Fungi - genetics Fungi - metabolism Gene clusters Genes Genetic aspects Genetic research Genome, Fungal Genomes Genomics Infectious Diseases Life cycle engineering Life cycles Life Sciences Medical Microbiology Metabolic Networks and Pathways Metabolic pathways Metabolism Microbiology Multigene Family Parasitology Phylogeny Review Article Virology |
| title | The birth, evolution and death of metabolic gene clusters in fungi |
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