Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
This work reports the first images obtained by combining an infrared aperture scanning near-field optical microscope (SNOM) with a quantum cascade laser (QCL). The future potential of this set-up is demonstrated by a preliminary study on an OE33 human oesophageal adenocarcinoma cell in which the cel...
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| Veröffentlicht in: | Analyst (London) 2018-12, Vol.143 (24), p.5912-5917 |
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| container_title | Analyst (London) |
| container_volume | 143 |
| creator | Smith, Caroline I Siggel-King, Michele R. F Ingham, James Harrison, Paul Martin, David S Varro, Andrea Pritchard, D. Mark Surman, Mark Barrett, Steve Weightman, Peter |
| description | This work reports the first images obtained by combining an infrared aperture scanning near-field optical microscope (SNOM) with a quantum cascade laser (QCL). The future potential of this set-up is demonstrated by a preliminary study on an OE33 human oesophageal adenocarcinoma cell in which the cell is imaged at 1751 cm
−1
, 1651 cm
−1
, 1539 cm
−1
and 1242 cm
−1
. In addition to the 1651 cm
−1
image, three other images were acquired within the Amide I band (1689 cm
−1
, 1675 cm
−1
and 1626 cm
−1
) chosen to correspond to secondary structures of proteins. The four images obtained within the Amide I band show distinct differences demonstrating the potential of this approach to reveal subtle changes in the chemical composition of a cell.
First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell. |
| doi_str_mv | 10.1039/c8an01183d |
| format | Article |
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−1
, 1651 cm
−1
, 1539 cm
−1
and 1242 cm
−1
. In addition to the 1651 cm
−1
image, three other images were acquired within the Amide I band (1689 cm
−1
, 1675 cm
−1
and 1626 cm
−1
) chosen to correspond to secondary structures of proteins. The four images obtained within the Amide I band show distinct differences demonstrating the potential of this approach to reveal subtle changes in the chemical composition of a cell.
First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.</description><identifier>ISSN: 0003-2654</identifier><identifier>EISSN: 1364-5528</identifier><identifier>DOI: 10.1039/c8an01183d</identifier><identifier>PMID: 30191233</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - pathology ; Apertures ; Cell Line, Tumor ; Chemical composition ; Epithelial Cells - pathology ; Esophageal cancer ; Humans ; Image acquisition ; Lasers, Semiconductor ; Microscopy - instrumentation ; Microscopy - methods ; Near field optical microscopes ; Organic chemistry ; Proteins ; Quantum cascade lasers</subject><ispartof>Analyst (London), 2018-12, Vol.143 (24), p.5912-5917</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-dfcb19c20a17cb4471c0d20296834805c16cbddfdeda1346c3af902a1ab836103</citedby><cites>FETCH-LOGICAL-c363t-dfcb19c20a17cb4471c0d20296834805c16cbddfdeda1346c3af902a1ab836103</cites><orcidid>0000-0002-0907-3930 ; 0000-0003-2960-3334</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2829,2830,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30191233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Caroline I</creatorcontrib><creatorcontrib>Siggel-King, Michele R. F</creatorcontrib><creatorcontrib>Ingham, James</creatorcontrib><creatorcontrib>Harrison, Paul</creatorcontrib><creatorcontrib>Martin, David S</creatorcontrib><creatorcontrib>Varro, Andrea</creatorcontrib><creatorcontrib>Pritchard, D. Mark</creatorcontrib><creatorcontrib>Surman, Mark</creatorcontrib><creatorcontrib>Barrett, Steve</creatorcontrib><creatorcontrib>Weightman, Peter</creatorcontrib><title>Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell</title><title>Analyst (London)</title><addtitle>Analyst</addtitle><description>This work reports the first images obtained by combining an infrared aperture scanning near-field optical microscope (SNOM) with a quantum cascade laser (QCL). The future potential of this set-up is demonstrated by a preliminary study on an OE33 human oesophageal adenocarcinoma cell in which the cell is imaged at 1751 cm
−1
, 1651 cm
−1
, 1539 cm
−1
and 1242 cm
−1
. In addition to the 1651 cm
−1
image, three other images were acquired within the Amide I band (1689 cm
−1
, 1675 cm
−1
and 1626 cm
−1
) chosen to correspond to secondary structures of proteins. The four images obtained within the Amide I band show distinct differences demonstrating the potential of this approach to reveal subtle changes in the chemical composition of a cell.
First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.</description><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - pathology</subject><subject>Apertures</subject><subject>Cell Line, Tumor</subject><subject>Chemical composition</subject><subject>Epithelial Cells - pathology</subject><subject>Esophageal cancer</subject><subject>Humans</subject><subject>Image acquisition</subject><subject>Lasers, Semiconductor</subject><subject>Microscopy - instrumentation</subject><subject>Microscopy - methods</subject><subject>Near field optical microscopes</subject><subject>Organic chemistry</subject><subject>Proteins</subject><subject>Quantum cascade lasers</subject><issn>0003-2654</issn><issn>1364-5528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQha2Kii5bLr2DjLggpJQZO8k6x9UCpVLVXuAcTWynpErs1HYO_fd42bZIHOqL5Xmfn2bmMXaGcI4gmy9akQNEJc0RW6Gsy6KqhHrFVgAgC1FX5Ql7E-NdfiJU8JqdSMAGhZQrlrbzPA6a0uAd9z0nfr-QS8vENUVNxvKRog2cZhvSEizPRecGd8udpVD0gx0N93PKFiOfBh181H62PHmefmc6Lebh4Jv_6Wyk7TiesuOexmjfPt5r9uv7t5-7H8XVzcXlbntVaFnLVJhed9hoAYQb3ZXlBjUYAaKplSwVVBpr3RnTG2sIZVlrSX0DgpA6Jeu8mjX7dPCdg79fbEztNMR9A-SsX2IrEFBsAJTK6Mf_0Du_BJe7y1SpZFXLfNbs84HazxmD7ds5DBOFhxah3WfR7tT2-m8WXzP8_tFy6SZrntGn5Wfg3QEIUT-r_8LM-oeX9HY2vfwDZEOZfQ</recordid><startdate>20181203</startdate><enddate>20181203</enddate><creator>Smith, Caroline I</creator><creator>Siggel-King, Michele R. 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F ; Ingham, James ; Harrison, Paul ; Martin, David S ; Varro, Andrea ; Pritchard, D. Mark ; Surman, Mark ; Barrett, Steve ; Weightman, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-dfcb19c20a17cb4471c0d20296834805c16cbddfdeda1346c3af902a1ab836103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - pathology</topic><topic>Apertures</topic><topic>Cell Line, Tumor</topic><topic>Chemical composition</topic><topic>Epithelial Cells - pathology</topic><topic>Esophageal cancer</topic><topic>Humans</topic><topic>Image acquisition</topic><topic>Lasers, Semiconductor</topic><topic>Microscopy - instrumentation</topic><topic>Microscopy - methods</topic><topic>Near field optical microscopes</topic><topic>Organic chemistry</topic><topic>Proteins</topic><topic>Quantum cascade lasers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Caroline I</creatorcontrib><creatorcontrib>Siggel-King, Michele R. F</creatorcontrib><creatorcontrib>Ingham, James</creatorcontrib><creatorcontrib>Harrison, Paul</creatorcontrib><creatorcontrib>Martin, David S</creatorcontrib><creatorcontrib>Varro, Andrea</creatorcontrib><creatorcontrib>Pritchard, D. Mark</creatorcontrib><creatorcontrib>Surman, Mark</creatorcontrib><creatorcontrib>Barrett, Steve</creatorcontrib><creatorcontrib>Weightman, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Analyst (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Caroline I</au><au>Siggel-King, Michele R. 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−1
, 1651 cm
−1
, 1539 cm
−1
and 1242 cm
−1
. In addition to the 1651 cm
−1
image, three other images were acquired within the Amide I band (1689 cm
−1
, 1675 cm
−1
and 1626 cm
−1
) chosen to correspond to secondary structures of proteins. The four images obtained within the Amide I band show distinct differences demonstrating the potential of this approach to reveal subtle changes in the chemical composition of a cell.
First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30191233</pmid><doi>10.1039/c8an01183d</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0907-3930</orcidid><orcidid>https://orcid.org/0000-0003-2960-3334</orcidid></addata></record> |
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| ispartof | Analyst (London), 2018-12, Vol.143 (24), p.5912-5917 |
| issn | 0003-2654 1364-5528 |
| language | eng |
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| source | MEDLINE; Royal Society of Chemistry Journals Archive (1841-2007); Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Apertures Cell Line, Tumor Chemical composition Epithelial Cells - pathology Esophageal cancer Humans Image acquisition Lasers, Semiconductor Microscopy - instrumentation Microscopy - methods Near field optical microscopes Organic chemistry Proteins Quantum cascade lasers |
| title | Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell |
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