Serum Carcinoembryonic Antigen Levels Before the First Curative Hepatectomy for Metastatic Colorectal Cancer Is a Predictor of Recurrence
The aim of this study was to evaluate the usefulness of serum carcinoembryonic antigen (CEA) levels before the first curative hepatectomy for metastatic colorectal cancer as a predictor of recurrence. Between 2003 and 2010, 66 patients (45 male and 21 female) who underwent a first curative hepatecto...
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| Veröffentlicht in: | Anticancer research 2018-09, Vol.38 (9), p.5351-5355 |
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| container_title | Anticancer research |
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| creator | Kawahara, Hidejiro Yoshida, Seiya Tohyama, Yoichi Yanagisawa, Satoru Misawa, Takeyuki Yanaga, Katsuhiko |
| description | The aim of this study was to evaluate the usefulness of serum carcinoembryonic antigen (CEA) levels before the first curative hepatectomy for metastatic colorectal cancer as a predictor of recurrence.
Between 2003 and 2010, 66 patients (45 male and 21 female) who underwent a first curative hepatectomy for metastatic colorectal cancer in our hospital were evaluated retrospectively. The mean patient age was 65.2 years (range=31-80 years). A total of 28 patients had synchronous liver metastasis, and the other 38 patients developed metachronous liver metastasis.
The 5-year relapse-free survival rate after the first hepatectomy of the 16 patients with normal serum CEA level was 61.1%, whereas that of the 50 patients with abnormal serum CEA level was 34.3% (p |
| doi_str_mv | 10.21873/anticanres.12863 |
| format | Article |
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Between 2003 and 2010, 66 patients (45 male and 21 female) who underwent a first curative hepatectomy for metastatic colorectal cancer in our hospital were evaluated retrospectively. The mean patient age was 65.2 years (range=31-80 years). A total of 28 patients had synchronous liver metastasis, and the other 38 patients developed metachronous liver metastasis.
The 5-year relapse-free survival rate after the first hepatectomy of the 16 patients with normal serum CEA level was 61.1%, whereas that of the 50 patients with abnormal serum CEA level was 34.3% (p<0.001). Among patients whose serum CEA levels were abnormal, the 5-year relapse-free survival rate after the first hepatectomy of the 34 patients with serum CEA levels less than 50 ng/ml was 48.1%, whereas that of the 16 patients with serum CEA level equal to or greater than 50 ng/ml was 6.3% (p<0.001). All eleven patients whose serum CEA levels were at least 100 ng/ml developed recurrence within one year after hepatectomy.
Serum CEA levels before the first curative hepatectomy for metastatic colorectal cancer seem to be a predictor of recurrence.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>DOI: 10.21873/anticanres.12863</identifier><identifier>PMID: 30194188</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Antigens ; Cancer ; Carcinoembryonic antigen ; Colorectal cancer ; Colorectal carcinoma ; Hepatectomy ; Liver ; Metastases ; Metastasis ; Patients ; Survival</subject><ispartof>Anticancer research, 2018-09, Vol.38 (9), p.5351-5355</ispartof><rights>Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Sep 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-5365b9a38f93f4239c9983815f42a1202f26f560fd07b170b5c13621ee6543a43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30194188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawahara, Hidejiro</creatorcontrib><creatorcontrib>Yoshida, Seiya</creatorcontrib><creatorcontrib>Tohyama, Yoichi</creatorcontrib><creatorcontrib>Yanagisawa, Satoru</creatorcontrib><creatorcontrib>Misawa, Takeyuki</creatorcontrib><creatorcontrib>Yanaga, Katsuhiko</creatorcontrib><title>Serum Carcinoembryonic Antigen Levels Before the First Curative Hepatectomy for Metastatic Colorectal Cancer Is a Predictor of Recurrence</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The aim of this study was to evaluate the usefulness of serum carcinoembryonic antigen (CEA) levels before the first curative hepatectomy for metastatic colorectal cancer as a predictor of recurrence.
Between 2003 and 2010, 66 patients (45 male and 21 female) who underwent a first curative hepatectomy for metastatic colorectal cancer in our hospital were evaluated retrospectively. The mean patient age was 65.2 years (range=31-80 years). A total of 28 patients had synchronous liver metastasis, and the other 38 patients developed metachronous liver metastasis.
The 5-year relapse-free survival rate after the first hepatectomy of the 16 patients with normal serum CEA level was 61.1%, whereas that of the 50 patients with abnormal serum CEA level was 34.3% (p<0.001). Among patients whose serum CEA levels were abnormal, the 5-year relapse-free survival rate after the first hepatectomy of the 34 patients with serum CEA levels less than 50 ng/ml was 48.1%, whereas that of the 16 patients with serum CEA level equal to or greater than 50 ng/ml was 6.3% (p<0.001). All eleven patients whose serum CEA levels were at least 100 ng/ml developed recurrence within one year after hepatectomy.
Serum CEA levels before the first curative hepatectomy for metastatic colorectal cancer seem to be a predictor of recurrence.</description><subject>Antigens</subject><subject>Cancer</subject><subject>Carcinoembryonic antigen</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Hepatectomy</subject><subject>Liver</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Patients</subject><subject>Survival</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLHUEQhZtg0KvxB2QTGtxkM9qP249Z6qBRuBIxuh56-lYnIzPT1-oe4f6E_Os0PiK4KorznUMVh5CvnB0Lbo08cVPuvZsQ0jEXVstPZMFNzSujJNshCyYUqwxjao_sp_TAmNa1lbtkTzJeL7m1C_L3F-A80sah76cIY4fbOPWenpbk3zDRFTzBkOgZhIhA8x-gFz2mTJsZXe6fgF7CxmXwOY5bWhh6DdmlXDRPmzgUk89uKPmTB6RXiTp6g7DuiwFpDPQW_IwIRf1CPgc3JDh8nQfk_uL8rrmsVj9_XDWnq8pLI3KlpFZd7aQNtQxLIWtfl58sV2VxXDARhA5Ks7BmpuOGdcpzqQUH0Gop3VIekO8vuRuMjzOk3I598jAMboI4p1ZwxoU2SqmCHn1AH-KMU7muUNJqZmpjC8VfKI8xJYTQbrAfHW5bztrnntr3ntrnnorn22vy3I2w_u94K0b-A7LkkQ8</recordid><startdate>201809</startdate><enddate>201809</enddate><creator>Kawahara, Hidejiro</creator><creator>Yoshida, Seiya</creator><creator>Tohyama, Yoichi</creator><creator>Yanagisawa, Satoru</creator><creator>Misawa, Takeyuki</creator><creator>Yanaga, Katsuhiko</creator><general>International Institute of Anticancer Research</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201809</creationdate><title>Serum Carcinoembryonic Antigen Levels Before the First Curative Hepatectomy for Metastatic Colorectal Cancer Is a Predictor of Recurrence</title><author>Kawahara, Hidejiro ; Yoshida, Seiya ; Tohyama, Yoichi ; Yanagisawa, Satoru ; Misawa, Takeyuki ; Yanaga, Katsuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-5365b9a38f93f4239c9983815f42a1202f26f560fd07b170b5c13621ee6543a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antigens</topic><topic>Cancer</topic><topic>Carcinoembryonic antigen</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Hepatectomy</topic><topic>Liver</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Patients</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawahara, Hidejiro</creatorcontrib><creatorcontrib>Yoshida, Seiya</creatorcontrib><creatorcontrib>Tohyama, Yoichi</creatorcontrib><creatorcontrib>Yanagisawa, Satoru</creatorcontrib><creatorcontrib>Misawa, Takeyuki</creatorcontrib><creatorcontrib>Yanaga, Katsuhiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawahara, Hidejiro</au><au>Yoshida, Seiya</au><au>Tohyama, Yoichi</au><au>Yanagisawa, Satoru</au><au>Misawa, Takeyuki</au><au>Yanaga, Katsuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum Carcinoembryonic Antigen Levels Before the First Curative Hepatectomy for Metastatic Colorectal Cancer Is a Predictor of Recurrence</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2018-09</date><risdate>2018</risdate><volume>38</volume><issue>9</issue><spage>5351</spage><epage>5355</epage><pages>5351-5355</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>The aim of this study was to evaluate the usefulness of serum carcinoembryonic antigen (CEA) levels before the first curative hepatectomy for metastatic colorectal cancer as a predictor of recurrence.
Between 2003 and 2010, 66 patients (45 male and 21 female) who underwent a first curative hepatectomy for metastatic colorectal cancer in our hospital were evaluated retrospectively. The mean patient age was 65.2 years (range=31-80 years). A total of 28 patients had synchronous liver metastasis, and the other 38 patients developed metachronous liver metastasis.
The 5-year relapse-free survival rate after the first hepatectomy of the 16 patients with normal serum CEA level was 61.1%, whereas that of the 50 patients with abnormal serum CEA level was 34.3% (p<0.001). Among patients whose serum CEA levels were abnormal, the 5-year relapse-free survival rate after the first hepatectomy of the 34 patients with serum CEA levels less than 50 ng/ml was 48.1%, whereas that of the 16 patients with serum CEA level equal to or greater than 50 ng/ml was 6.3% (p<0.001). All eleven patients whose serum CEA levels were at least 100 ng/ml developed recurrence within one year after hepatectomy.
Serum CEA levels before the first curative hepatectomy for metastatic colorectal cancer seem to be a predictor of recurrence.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>30194188</pmid><doi>10.21873/anticanres.12863</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Antigens Cancer Carcinoembryonic antigen Colorectal cancer Colorectal carcinoma Hepatectomy Liver Metastases Metastasis Patients Survival |
| title | Serum Carcinoembryonic Antigen Levels Before the First Curative Hepatectomy for Metastatic Colorectal Cancer Is a Predictor of Recurrence |
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