HLA-B58:01 and rs9263726 have a linkage, but not absolute linkage disequilibrium in Han Chinese population

HLA-B*58:01 has been demonstrated to be associated with allopurinol-induced severe cutaneous adverse reactions. Since HLA-B*58:01 is too complicated to be identified, it is necessary to select an appropriate surrogate biomarker. In Japan, the rs9263726 allele was considered as a surrogate biomarker...

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Veröffentlicht in:	Drug metabolism and pharmacokinetics 2018-10, Vol.33 (5), p.228-231
Hauptverfasser:	Dou, Yaling, Peng, Pan, Cai, Congli, Ye, Ali, Kong, Lingjun, Zhang, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Allopurinol-induced SCARs China Ethnic Groups - genetics Genotype Han Chinese HLA-B Antigens - genetics HLA-B58:01 Humans Linkage Disequilibrium rs9263726
Online-Zugang:	Volltext
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